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Cancer: Prostate Cancer

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Discussion PaperBritish Guideline on the management of asthmaDeveloping and Evaluating Methods for Record Linkage and Reducing Bias in Patient RegistriesNow, these are not specifically about immunisations but they'll all make reference to it.  For instance the top result has the following:Vaccinations1.4.2 Be aware that live vaccinations may be contraindicated in people with MS who are being treated with disease-modifying therapies.We return all the results that match the search terms (and/or synonyms).  However, our algorithm is designed to emphasise those results which are more relevant.  So, ordinarily, i...
Source: Liberating the literature - October 31, 2014 Category: Technology Consultants Source Type: blogs

Mp46-15 lipid nanoparticle sirna potently silences clusterin and delays progression when combined with androgen receptor co-targeting in enzalutamide resistant prostate cancer
Suppression of androgen receptor (AR) signaling remains a therapeutic goal for castration resistant prostate cancer (CRPC) and despite newer potent AR pathway inhibitors, resistance frequently occurs. While co-targeting the AR with adaptive survival pathways is a rational goal, many biologically relevant genes including clusterin (CLU) are not druggable with small molecule inhibitors. While small interfering RNA (siRNA) offers the promise for very potent and specific gene silencing, in vivo delivery remains a major barrier.
Source: The Journal of Urology - April 1, 2015 Category: Urology & Nephrology Authors: Yoshiaki Yamamoto, Paulo Lin, Fan Zhang, Eliana Beraldi, Yoshihisa Kawai, Jeffrey Leong, Hideyasu Matsuyama, Pieter Cullis, Martin Gleave Tags: Prostate Cancer: Basic Research II Source Type: research

Cyclodextrin mediated delivery of NF-κB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro
Cyclodextrin mediated delivery of NF-κB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro Gene Therapy advance online publication, June 18 2015. doi:10.1038/gt.2015.50 Authors: J C Evans, J McCarthy, C Torres-Fuentes, J F Cryan, J Ogier, R Darcy, R W Watson & C M O’Driscoll
Source: Gene Therapy - June 18, 2015 Category: Genetics & Stem Cells Authors: J C EvansJ McCarthyC Torres-FuentesJ F CryanJ OgierR DarcyR W WatsonC M O’Driscoll Source Type: research

Folate-targeted Amphiphilic Cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo
In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA). Targeted formulations showed increased uptake, relative to untargeted controls, in two prostate cancer cell lines expressing PSMA (VCaP and LNCaP). Competitive uptake studies, using excess folate, significantly reduced uptake of targeted nanoparticles in PSMA positive cell lines (p
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - July 3, 2016 Category: Nanotechnology Authors: James C. Evans, Meenakshi Malhotra, Jianfeng Guo, Joseph P. O'Shea, Karen Hanrahan, Amanda O'Neill, William Landry, Brendan T. Griffin, Raphael Darcy, R. William Watson, Caitriona M. O'Driscoll Source Type: research

Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo
In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA). Targeted formulations showed increased uptake, relative to untargeted controls, in two prostate cancer cell lines expressing PSMA (VCaP and LNCaP). Competitive uptake studies, using excess folate, significantly reduced uptake of targeted nanoparticles in PSMA positive cell lines (P
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - July 3, 2016 Category: Nanotechnology Authors: James C. Evans, Meenakshi Malhotra, Jianfeng Guo, Joseph P. O'Shea, Karen Hanrahan, Amanda O'Neill, William Landry, Brendan T. Griffin, Raphael Darcy, R. William Watson, Caitriona M. O'Driscoll Source Type: research

SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer
Conclusion: This study presented a bone-cancer dual-targeting biomimetic nanodelivery system for bone metastatic CRPC.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jiyuan Chen, Zhenjie Wu, Weihong Ding, Chengwu Xiao, Yu Zhang, Shen Gao, Yuan Gao, Weimin Cai Tags: Research Paper Source Type: research

Mesoporous silica nanoparticles combined with AKR1C3 siRNA inhibited the growth of castration-resistant prostate cancer by suppressing androgen synthesis in  vitro and in vivo.
In this study, mesoporous silica nanoparticles (MSNs) were employed to deliver small interfering RNA targeting AKR1C3 (siAKR1C3) to downregulate AKR1C3 expression in CPRC cells. The optimal weight ratio of MSNs/siAKR1C3 was determined by a gel retardation assay. Prostate cancer cells such as VCaP cells, which intracrinally express AKR1C3, and LNCaP-AKR1C3 cells stably transfected with AKR1C3 were used to investigate the antitumour effect of MSNs-siAKR1C3. Fluorescence detection and Western blot analyses were applied to confirm the entrance of MSNs-siAKR1C3 into the cells. A SRB (Sulforhodamine B) assay was employed to asse...
Source: Biochemical and Biophysical Research communications - January 12, 2021 Category: Biochemistry Authors: Chen J, Yang Y, Xu D, Li J, Wu S, Jiang Y, Wang C, Yang Z, Zhao L Tags: Biochem Biophys Res Commun Source Type: research

GSE172094 siRNA-mediated E2F1 and E2F2 silencing in growth-stimulated prostate cancer cells
Contributors : Salma Ben-Salem ; Eduardo Cortes ; Qiang Hu ; Song Liu ; Hannelore HeemersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the effect of siRNA-mediated E2F1 and E2F2 silencing in growth-stimulated prostate cancer cells.
Source: GEO: Gene Expression Omnibus - October 14, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Screening for prostate cancer.
CONCLUSIONS: Prostate cancer screening did not significantly decrease prostate cancer-specific mortality in a combined meta-analysis of five RCTs. Only one study (ERSPC) reported a 21% significant reduction of prostate cancer-specific mortality in a pre-specified subgroup of men aged 55 to 69 years. Pooled data currently demonstrates no significant reduction in prostate cancer-specific and overall mortality. Harms associated with PSA-based screening and subsequent diagnostic evaluations are frequent, and moderate in severity. Overdiagnosis and overtreatment are common and are associated with treatment-related harms. Men sh...
Source: Cochrane Database of Systematic Reviews - March 2, 2013 Category: Journals (General) Authors: Ilic D, Neuberger MM, Djulbegovic M, Dahm P Tags: Cochrane Database Syst Rev Source Type: research

Hypothesis driven single nucleotide polymorphism search (HyDn-SNP-S).
Abstract The advent of complete-genome genotyping across phenotype cohorts has provided a rich source of information for bioinformaticians. However the search for SNPs from this data is generally performed on a study-by-study case without any specific hypothesis of the location for SNPs that are predictive for the phenotype. We have designed a method whereby very large SNP lists (several gigabytes in size), combining several genotyping studies at once, can be sorted and traced back to their ultimate consequence in protein structure. Given a working hypothesis, researchers are able to easily search whole genome gen...
Source: DNA Repair - July 4, 2013 Category: Genetics & Stem Cells Authors: Swett RJ, Elias A, Miller JA, Dyson GE, Andrés Cisneros G Tags: DNA Repair (Amst) Source Type: research

Robotic-assisted minimally invasive surgery for gynecologic and urologic oncology: an evidence-based analysis.
Authors: Health Quality Ontario Abstract OBJECTIVE: An application was received to review the evidence on the 'The Da Vinci Surgical System' for the treatment of gynecologic malignancies (e.g. endometrial and cervical cancers). Limitations to the current standard of care include the lack of trained physicians on minimally invasive surgery and limited access to minimally invasive surgery for patients. The potential benefits of 'The Da Vinci Surgical System' include improved technical manipulation and physician uptake leading to increased surgeries, and treatment and management of these cancers. The demand for roboti...
Source: Ontario Health Technology Assessment Series - December 20, 2015 Category: Journals (General) Tags: Ont Health Technol Assess Ser Source Type: research

Gene expression feature selection for prostate cancer diagnosis using a two-phase heuristic–deterministic search strategy
Here, a two-phase search strategy is proposed to identify the biomarkers in gene expression data set for the prostate cancer diagnosis. A statistical filtering method is initially employed to remove the noisiest data. In the first phase of the search strategy, a multi-objective optimisation based on the binary particle swarm optimisation algorithm tuned by a chaotic method is proposed to select the optimal subset of genes with the minimum number of genes and the maximum classification accuracy. Finally, in the second phase of the search strategy, the cache-based modification of the sequential forward floating selection alg...
Source: IET Systems Biology - August 14, 2018 Category: Biology Source Type: research

In Search for risk predictors at the microscopic scenario of a negative biopsy. A systematic review.
CONCLUSIONS: The MS of a negative PB may include atypical small acinar proliferation, HGPIN, prostatic atrophy, inflammatory proliferative atrophy and prostatic inflammation lesions, since they all seem to be associated with the risk of PC detection in repeat PB. This review has led us to create the hypothesis that the MS of a negative PB might be a valuable and useful tool when considering repeat PB. PMID: 31109736 [PubMed - as supplied by publisher]
Source: Actas Urologicas Espanolas - May 16, 2019 Category: Urology & Nephrology Authors: Schwartzmann I, Celma A, Gallardo I, Moreno O, Regis L, Placer J, Planas J, Trilla Herrero E, Morote Robles J Tags: Actas Urol Esp Source Type: research

Internet use after prostate cancer : Search for information and trust in disease-related information in long-term survivors.
CONCLUSIONS: Two-thirds of long-term PCa survivors are using the internet. A significant proportion expressed difficulties finding proper and reliable information. Urologists should be familiar with online resources on PCa in order to offer advice to patients and to recommend adequate information on the internet. PMID: 31172242 [PubMed - as supplied by publisher]
Source: Der Urologe. Ausg. A - June 5, 2019 Category: Urology & Nephrology Authors: Linden AJ, Dinkel A, Schiele S, Meissner VH, Gschwend JE, Herkommer K Tags: Urologe A Source Type: research

Practically scheduling hormone therapy for prostate cancer using a mathematical model
Publication date: Available online 13 June 2019Source: Journal of Theoretical BiologyAuthor(s): Ayako Nakanishi, Yoshito HirataAbstractHormone therapy is one of the popular therapeutic methods for prostate cancer. Intermittent androgen suppression (IAS) is the method which stops and resumes hormone therapy repeatedly. The efficacy of IAS differs depending on patients; both the cases have been reported where the relapse of cancer happened and did not happen, for the patients who had undergone IAS. For the patients who cannot avoid the relapse of cancer by IAS, we should delay the relapse of cancer as later as possible. Here...
Source: Journal of Theoretical Biology - June 14, 2019 Category: Biology Source Type: research