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Cancer: Lung Cancer
Nutrition: Zinc
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Total 141 results found since Jan 2013.
Are Zn(II) pincer complexes efficient apoptosis inducers? A deeper insight against A549 lung cancer cells
Dalton Trans., 2023, Accepted Manuscript DOI: 10.1039/D3DT02419A, PaperAthulya Das, Muniyandi Sankaralingam To expand the array of chemotherapeutic drugs, the earth-abundant metal complexes are found to be the future direction. In this regard, new zinc(II) complexes 1 – 3 of 8-aminoquinoline based... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - September 14, 2023 Category: Chemistry Authors: Athulya Das Source Type: research
Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration
CONCLUSIONS: Moderate-certainty evidence suggests that antioxidant vitamin and mineral supplementation (AREDS: vitamin C, E, beta-carotene, and zinc) probably slows down progression to late AMD. People with intermediate AMD have a higher chance of benefiting from antioxidant supplements because their risk of progression is higher than people with early AMD. Although low-certainty evidence suggested little effect with lutein/zeaxanthin alone compared with placebo, exploratory subgroup analyses from one large American study support the view that lutein/zeaxanthin may be a suitable replacement for the beta-carotene used in th...
Source: Cochrane Database of Systematic Reviews - September 13, 2023 Category: General Medicine Authors: Jennifer R Evans John G Lawrenson Source Type: research
Galactomannan polysaccharide as a biotemplate for the synthesis of zinc oxide nanoparticles with photocatalytic, antimicrobial and anticancer applications
Int J Biol Macromol. 2023 Sep 8:126787. doi: 10.1016/j.ijbiomac.2023.126787. Online ahead of print.ABSTRACTBio-templates provide a facile, rapid, and environmentally benign route for synthesizing various nanostructured materials. Herein, Locust Bean Gum (LBG), a galactomannan polysaccharide, has been used as a biotemplate for synthesizing ZnO nanoparticles (NPs) for the first time. The composition, structure, morphology, and bandgap of ZnO were investigated by Energy Dispersive X-ray Spectroscopy (EDX), X-Ray Photoelectron Spectroscopy (XPS), X-ray powder diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission ...
Source: International Journal of Biological Macromolecules - September 10, 2023 Category: Biochemistry Authors: Amol Kahandal Sanyukta Chaudhary Saakshi Methe Pratik Nagwade Aruna Sivaram Chandrakant K Tagad Source Type: research
Impacts of LncRNA NORAD on the Proliferation, Apoptosis, and Chemosensitivity of Non-small Cell Lung Cancer Cells by Regulating ZNF217 through MiR-199a-3p
CONCLUSIONS: Down-regulating NORAD expression can enhance miR-199a-3p expression and inhibit ZNF217 expression, thereby inhibiting H460/DDP cell proliferation, promoting apoptosis and enhancing its DDP chemotherapy sensitivity.PMID:37653011 | DOI:10.3779/j.issn.1009-3419.2023.102.27
Source: Cancer Control - August 31, 2023 Category: Cancer & Oncology Authors: Ying Gao Xiaolin Luo Pengfei Liao Yuanyuan Luo Source Type: research
A pancancer analysis of the oncogenic role of ZNRF2 in human tumours
J Cell Mol Med. 2023 Aug 8. doi: 10.1111/jcmm.17900. Online ahead of print.ABSTRACTFinding effective treatments for cancer requires a thorough understanding of how it develops and progresses. Recent research has revealed the crucial role that Zinc and ring finger 2 (ZNRF2) play in the progression of non-small cell lung cancer (NSCLC) by controlling cell growth and death. However, a comprehensive analysis of ZNRF2's role in cancer as a whole has yet to be conducted. Our study sought to investigate the impact of ZNRF2 on diverse human tumours, as well as the molecular pathways involved, using databases such as TCGA (The Canc...
Source: J Cell Mol Med - August 8, 2023 Category: Molecular Biology Authors: Fujie Shi Yunfei Wu Kai Wang Jiafan Wang Minghui Liu Xinlei Sun Source Type: research
Identification of a novel therapeutic target for lung cancer: Mitochondrial ribosome protein L9
In this study, the screening process was based on lung cancer expression profile data and survival analysis. Mitochondrial ribosome protein L9 (MRPL9) was upregulated in lung cancer tissues and related to the poor overall survival rate and recurrence-free survival rate of lung cancer patients. Knockdown of MRPL9 inhibited the proliferation, sphere-formation, and migration ability of lung cancer cells. MRPL9 was associated with the c-MYC signaling pathway, and lung cancer patients with high expression of both MRPL9 and MYC had a poor prognosis. Furthermore, c-MYC was associated with the epithelial-mesenchymal transition (EM...
Source: Pathology, Research and Practice - June 21, 2023 Category: Pathology Authors: Xin-Yuan Li Xin-Yu He Hong Zhao Lu Qi Jin-Jian Lu Source Type: research
ZEB1 is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis
Mol Cancer Res. 2023 May 31:OF1-OF16. doi: 10.1158/1541-7786.MCR-22-0503. Online ahead of print.ABSTRACTEpithelial-to-mesenchymal transition results in loss of specialized epithelial cell contacts and acquisition of mesenchymal invasive capacity. The transcription repressor zinc finger E-box-binding homeobox 1 (ZEB1) binds to E-boxes of gene promoter regions to suppress the expression of epithelial genes. ZEB1 has inconsistent molecular weights, which have been attributed to posttranslational modifications (PTM). We performed mass spectrometry and identified K811 acetylation as a novel PTM in ZEB1. To define the role of ZE...
Source: Cell Research - May 31, 2023 Category: Cytology Authors: Mabel Perez-Oquendo Roxsan Manshouri Yanhua Tian Jared J Fradette B Leticia Rodriguez Samrat T Kundu Don L Gibbons Source Type: research
Nutrition Support in Critically Ill Cancer Patient Receiving Extracorporeal Membrane Oxygenation: A Case Report
Clin Nutr Res. 2023 Apr 30;12(2):91-98. doi: 10.7762/cnr.2023.12.2.91. eCollection 2023 Apr.ABSTRACTAdequate nutritional support is crucial in preventing complications and improving outcomes in critically ill patients. Extracorporeal membrane oxygenation (ECMO) is a mode of supportive care for patients with respiratory and/or cardiac failure. ECMO patients frequently exhibit a hypermetabolic state characterized by protein catabolism and insulin resistance, which can lead to malnutrition. Nutritional therapy is a vital component of intensive care, but its optimal administration for ECMO patients is unknown. This case report...
Source: Clinical Lung Cancer - May 22, 2023 Category: Cancer & Oncology Authors: Ji-Yeon Kim Gyung-Ah Wie Kyoung-A Ryu So-Young Kim Source Type: research
Antiplatelet, cytotoxic activities and characterization of green-synthesized zinc oxide nanoparticles using aqueous extract of Nephrolepis exaltata
Environ Sci Pollut Res Int. 2023 May 17. doi: 10.1007/s11356-023-27483-3. Online ahead of print.ABSTRACTThe goal of the current study was to synthesize zinc oxide nanoparticles (ZnO-NPs) using ZnCl2.2H2O salt precursor and an aqueous extract of Nephrolepis exaltata (N. exaltata), which act as a capping and reducing agent. N. exaltata plant extract-mediated ZnO-NPs were further characterized by various techniques, such as X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FT-IR), UV-visible (UV-Vis), and energy-dispersive X-ray (EDX) analysis. The nanoscale crystalline pha...
Source: Environmental Science and Pollution Research International - May 17, 2023 Category: Environmental Health Authors: Mourad A M Aboul-Soud Rashid Siddique Fozia Fozia Asad Ullah Yasir Rashid Ijaz Ahmad Nouf S S Zaghloul Salim S Al-Rejaie Mohamed Mohany Source Type: research
ZEB1 is regulated by K811 acetylation to promote stability, NuRD complex interactions, EMT, and NSCLC metastasis
Mol Cancer Res. 2023 May 12:MCR-22-0503. doi: 10.1158/1541-7786.MCR-22-0503. Online ahead of print.ABSTRACTEpithelial-to-mesenchymal transition results in loss of specialized epithelial cell contacts and acquisition of mesenchymal invasive capacity. The transcription repressor zinc finger E-box-binding homeobox 1 (ZEB1) binds to E-boxes of gene promoter regions to suppress the expression of epithelial genes. ZEB1 has inconsistent molecular weights, which have been attributed to post-translational modifications (PTMs). We performed mass spectrometry and identified K811 acetylation as a novel PTM in ZEB1. To define the role ...
Source: Cell Research - May 12, 2023 Category: Cytology Authors: Mabel Perez-Oquendo Roxsan Manshouri Yanhua Tian Jared J Fradette B Leticia Rodriguez Samrat T Kundu Don L Gibbons Source Type: research
The role of KLF transcription factor in the regulation of cancer progression
Biomed Pharmacother. 2023 Apr 15;162:114661. doi: 10.1016/j.biopha.2023.114661. Online ahead of print.ABSTRACTKruppel-like factors (KLFs) are a family of zinc finger transcription factors that have been found to play an essential role in the development of various human tissues, including epithelial, teeth, and nerves. In addition to regulating normal physiological processes, KLFs have been implicated in promoting the onset of several cancers, such as gastric cancer, lung cancer, breast cancer, liver cancer, and colon cancer. To inhibit cancer progression, various existing medicines have been used to modulate the expressio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2023 Category: Drugs & Pharmacology Authors: Zi-Yi Li Yu-Xin Zhu Jian-Rui Chen Xu Chang Zhen-Zhen Xie Source Type: research
