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Specialty: Cytology
Cancer: Adenocarcinoma

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Total 37 results found since Jan 2013.

Interleukin-22 enhances chemoresistance of lung adenocarcinoma cells to paclitaxel
AbstractThe chemoresistance of tumors is the main barrier to cancer treatment. Interleukin-22 (IL-22) plays an important role in the chemoresistance of multi-cancers; however, the roles of IL-22 in the paclitaxel resistance of lung adenocarcinoma cells remain to be investigated. The present study aims to investigate the potential mechanisms of IL-22 enhancing the chemoresistance of lung adenocarcinoma cells to paclitaxel. We cultured A549, H358, and A549/PTX cell lines. qRT-PCR and western blot assays were performed to examine the mRNA and/or protein levels of IL-22 in A549, A549/PTX, H358, and H358/PTX. Moreover, cells we...
Source: Human Cell - May 24, 2020 Category: Cytology Source Type: research

TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer
CONCLUSION: TrkB/BDNF signaling may be a new therapeutic target for PDAC. Therapies targeting TrkB/BDNF signaling may be a conclusive cancer therapy for refractory solid cancer.PMID:34281873 | DOI:10.21873/anticanres.15205
Source: Cell Research - July 20, 2021 Category: Cytology Authors: Yasuhiro Oyama Shinjiro Nagao Lin Na Kosuke Yanai Masayo Umebayashi Katsuya Nakamura Shuntaro Nagai Akiko Fujimura Akio Yamasaki Kazunori Nakayama Takashi Morisaki Hideya Onishi Source Type: research

S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis
ConclusionOur study suggests that the S100A8/A9-RAGE signal pathway is the mainstream of the inflammation-immune response induced in cancer progression in CSE-related smoke-induced lung carcinogenesis in vitro and in vivo. Further studies are needed to identify the therapeutic targets of cigarette smoke-induced inflammation and immunosuppression in the tumor microenvironment.
Source: Molecular and Cellular Toxicology - March 15, 2023 Category: Cytology Source Type: research

Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer.
In conclusion, there is a crosstalk between polyamines and MAT2A. Increased MAT2A expression provides more SAMe for polyamines biosynthesis; increased polyamine (putrescine in this case) can activate MAT2A at the transcriptional level. This along with increased ODC expression in cancer all feed forward to further enhance the proliferative capacity of the cancer cell. PMID: 23588207 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - April 12, 2013 Category: Cytology Authors: Tomasi ML, Ryoo M, Skay A, Tomasi I, Giordano P, Mato JM, Lu SC Tags: Exp Cell Res Source Type: research

Expression of kinesin family member C1 in pancreatic ductal adenocarcinoma affects tumor progression and stemness
This study aimed to analyze the expression and biological function of KIFC1 in PDAC. Immunohistochemically, KIFC1 was found in 37 of 81 PDAC cases (46%). A high expression of KIFC1 was significantly related to tumor size (p = 0.023) and poor overall survival (p = 0.011). Univariate and multivariate analysis indicated that KIFC1 expression was a prognostic factor in PDAC cases. As for cancer stem cell markers, KIFC1 expression tended to co-express significantly with CD44 (p < 0.01). The growth and spheroid colony formation of KIFC1 small interfering RNA (siRNA)-transfected PDAC cells were significantly lower than those o...
Source: Cell Research - December 24, 2022 Category: Cytology Authors: Akira Ishikawa Hiroki Fujii Takafumi Fukui Aya Kido Narutaka Katsuya Kazuhiro Sentani Kazuya Kuraoka Sho Tazuma Takeshi Sudo Masahiro Serikawa Shiro Oka Naohide Oue Source Type: research

Myostatin-induced inhibition of the long noncoding RNA Malat1 is associated with decreased myogenesis
Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily of secreted proteins, is a potent negative regulator of myogenesis. Free myostatin induces the phosphorylation of the Smad family of transcription factors, which, in turn, regulates gene expression, via the canonical TGF-β signaling pathway. There is, however, emerging evidence that myostatin can regulate gene expression independent of Smad signaling. As such, we acquired global gene expression data from the gastrocnemius muscle of C57BL/6 mice following a 6-day treatment with recombinant myostatin compared with vehicle-treated anima...
Source: AJP: Cell Physiology - May 15, 2013 Category: Cytology Authors: Watts, R., Johnsen, V. L., Shearer, J., Hittel, D. S. Tags: ARTICLES Source Type: research

Myostatin-induced inhibition of the long noncoding RNA Malat1 is associated with decreased myogenesis.
Abstract Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily of secreted proteins, is a potent negative regulator of myogenesis. Free myostatin induces the phosphorylation of the Smad family of transcription factors, which, in turn, regulates gene expression, via the canonical TGF-β signaling pathway. There is, however, emerging evidence that myostatin can regulate gene expression independent of Smad signaling. As such, we acquired global gene expression data from the gastrocnemius muscle of C57BL/6 mice following a 6-day treatment with recombinant myostatin compared with vehicle-treated...
Source: American Journal of Physiology. Cell Physiology - May 1, 2013 Category: Cytology Authors: Watts R, Johnsen VL, Shearer J, Hittel DS Tags: Am J Physiol Cell Physiol Source Type: research

Non-overlapping activities of ADF and cofilin-1 during the migration of metastatic breast tumor cells
Conclusion: Although ADF and cofilin have many redundant functions, each of these isoforms has functional differences that affect F-actin structures, cell adhesion and lamellipodial dynamics, all of which are important determinants of cell migration.
Source: BMC Cell Biology - Latest articles - October 5, 2013 Category: Cytology Authors: Lubna TahtamouniAlisa ShawMaram HasanSalem YasinJames Bamburg Source Type: research

miR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX.
Abstract The poor prognosis of invasive ductal adenocarcinoma of the pancreas is mainly due to its resistance against therapeutic agents. The molecular mechanism by which morbidity enhances cell survival has been extensively studied, but radical improvements in the therapeutic strategy have not yet been achieved. Recent reports have indicated the substantial contribution of miRNA in multiple cell functions by comprehensively targeting clusters of genes. We identified several miRNAs highly expressed in invasive ductal adenocarcinoma in our previous study, and clarified their contribution to the epithelial-mesenchym...
Source: Cellular Signalling - November 8, 2013 Category: Cytology Authors: Hamada S, Masamune A, Miura S, Satoh K, Shimosegawa T Tags: Cell Signal Source Type: research

Chemokine (C‐C motif) ligand 5 is involved in tumor‐associated dendritic cell‐mediated colon cancer progression through non‐coding RNA MALAT‐1
In conclusion, the inhibition of CCL5 or CCL5‐related signaling may be an attractive therapeutic target in colon cancer patients. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 24, 2014 Category: Cytology Authors: Jung‐Yu Kan, Deng‐Chyang Wu, Fang‐Jung Yu, Cheng‐Ying Wu, Ya‐Wen Ho, Yen‐Jung Chiu, Shu‐Fang Jian, Jen‐Yu Hung, Jaw‐Yuan Wang, Po‐Lin Kuo Tags: Original Research Article Source Type: research

PKCδ-iPLA2-PGE2-PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells.
In conclusion, TNF-α induced CLDN1 expression is regulated by the PKCδ-iPLA2-PGE2-PPARγ signaling cascade in human lung carcinoma A549 cells. PMID: 25562426 [PubMed - as supplied by publisher]
Source: Cellular Signalling - January 3, 2015 Category: Cytology Authors: Iitaka D, Moodley S, Shimizu H, Bai X, Liu M Tags: Cell Signal Source Type: research

Overexpression of Long Non-Coding RNA ZXF2 Promotes Lung Adenocarcinoma Progression Through c-Myc Pathway
Objective: To investigate the expression of long non-coding RNA ZXF2 in lung adenocarcinoma tissues and its effect on cell proliferation, migration and invasion. Methods: Forty pairs of cancerous and adjacent non-cancerous lung adenocarcinoma specimens were collected for the studies. Quantitative real-time PCR was used to analyze the expression of ZXF2 in tumor tissues and adjacent normal tissues. The expression of ZXF2 was correlated with patients' clinico-pathological data. Molecular pathway controlled by ZXF2 was explored by using small interfering RNA (siRNA) technology. CCK-8 cell proliferation assay, flow cytometry a...
Source: Cellular Physiology and Biochemistry - April 18, 2015 Category: Cytology Source Type: research

Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)-mediated endoplasmic reticulum stress.
Abstract Costunolide is an active sesquiterpene lactone derived from many herbal medicines. It has a broad spectrum of bioactivities, including anti-inflammatory and potential anti-tumor effects. The aims of the present study were to evaluate the inhibitory effects of costunolide on A549 cell growth and to explore the underlying molecular mechanisms. Annexin V-FITC/PI flow cytometry analysis revealed that costunolide induced apoptosis. To study the mechanism, we found that costunolide exposure activated the unfolded protein response (UPR) signaling pathways, as shown by the up-regulation of GRP78 and IRE1α and th...
Source: Cell Biology International - November 26, 2015 Category: Cytology Authors: Wang Z, Zhao X, Gong X Tags: Cell Biol Int Source Type: research

Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein.
Abstract Oncogenic activation of the PI3K/Akt pathway is known to play an important role in promoting glucose metabolism in cancer cells. However, the molecular mechanism through which the PI3K/Akt signalling pathway promotes glucose utilisation in cancer cells is still not well understood. It has recently been shown that the oncogenic activation of the PI3K/Akt/mTOR signalling in lung adenocarcinoma is important in promoting the localisation of glucose transporter 1 (GLUT1) at the plasma membrane. We thus hypothesised that the effect of constitutive activation of the PI3K/AKT signalling on glucose metabolism is m...
Source: Cellular Signalling - January 27, 2016 Category: Cytology Authors: Hong SY, Yu FX, Luo Y, Hagen T Tags: Cell Signal Source Type: research

Negative control of TRAIL-R1 signaling by transforming growth factor β1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by both, overexpression of transforming growth factor (TGF)β and resistance of the tumor cells to many apoptosis-inducing stimuli. The latter negatively impacts the outcome of therapeutic efforts and represents one important mechanism which tumor cells utilize to escape the immune surveillance. Since TGFβ acts as a tumor promoter in advanced tumor stages and suppression of apoptosis is a known driver of tumor progression, it is possible that TGFβ functions as a crucial determinant of tumor cell sensitivity to apoptosis in PDAC. Here, we have stud...
Source: Cellular Signalling - July 31, 2016 Category: Cytology Authors: Radke DI, Ungefroren H, Helm O, Voigt S, Alp G, Braun H, Hübner S, Dilchert J, Sebens S, Adam D, Kalthoff H, Trauzold A Tags: Cell Signal Source Type: research