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Specialty: Gastroenterology
Cancer: Adenocarcinoma

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Total 20 results found since Jan 2013.

Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells
ConclusionsOur results highlight KRT17 as a possible biomarker in gastric cancer promoting tumor growth, motility, and invasion, and suggest that KRT17 can be a valuable molecular target for development of anti-gastric cancer-specific therapies.
Source: Gastric Cancer - March 14, 2017 Category: Gastroenterology Source Type: research

Role Of Intracellular Calcium And NADPH Oxidase NOX5-S In Acid-Induced DNA Damage In Barrett's cells and Barrett's Esophageal Adenocarcinoma Cells.
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca(2+) in FLO cells, an increase which is blocked by Ca(2+) free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of i...
Source: Am J Physiol Gastroi... - April 3, 2014 Category: Gastroenterology Authors: Li D, Cao W Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy.
CONCLUSION: SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model, thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment. PMID: 24764668 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 21, 2014 Category: Gastroenterology Authors: Matsushita K, Shimada H, Ueda Y, Inoue M, Hasegawa M, Tomonaga T, Matsubara H, Nomura F Tags: World J Gastroenterol Source Type: research

Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca2+ in FLO cells, an increase that is blocked by Ca2+-free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of intrac...
Source: AJP: Gastrointestinal and Liver Physiology - May 15, 2014 Category: Gastroenterology Authors: Li, D., Cao, W. Tags: CANCER BIOLOGY Source Type: research

Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells.
CONCLUSION: These results suggest that claudin 1 is an important messenger that regulates TNF-α-induced gene expression and migration in gastric cancer cells. A deeper understanding of these cellular processes may be helpful in establishing new therapeutic strategies for gastric cancer. PMID: 25548484 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 21, 2014 Category: Gastroenterology Authors: Shiozaki A, Shimizu H, Ichikawa D, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Iitaka D, Nakashima S, Nako Y, Liu M, Otsuji E Tags: World J Gastroenterol Source Type: research

The role of MALAT-1 in the invasion and metastasis of gastric cancer.
CONCLUSIONS: MALAT-1 may promote the migration and invasion of GC cells in part by regulating EMT. PMID: 28276823 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - March 11, 2017 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.
CONCLUSION: HuR mediated overexpression of IAP1 significantly correlates with poor outcomes and early progression of pancreatic cancer. Further studies are needed to assess the underlying mechanisms. PMID: 30670910 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z Tags: World J Gastroenterol Source Type: research

EZH2 Regulates Intestinal Inflammation and Necroptosis Through the JNK Signaling Pathway in Intestinal Epithelial Cells
ConclusionOur data suggest that EZH2 plays an important role in the development of intestinal inflammation and necroptosis. Hence, EZH2 could be a potential therapeutic target for IBD.
Source: Digestive Diseases and Sciences - July 3, 2019 Category: Gastroenterology Source Type: research

Expression of bile acid receptor TGR5 in gastric adenocarcinoma
In this study, we determined the expression of TGR5 in gastric adenocarcinoma and examined the role of TGR5 in cell proliferation. Strong TGR5 staining was present in 12% of cases of intestinal metaplasia but in no cases of normal gastric epithelium (P < 0.01). Moderate to strong TGR5 membranous and cytoplasmic staining was present in 52% of the intestinal but in only 25% of the diffuse subtype of adenocarcinomas (P < 0.001). Kaplan-Meier univariate survival analysis revealed that moderate to strong TGR5 staining was associated with decreased patient survival (P < 0.05). Treatment with taurodeoxycholic acid (TDCA,...
Source: AJP: Gastrointestinal and Liver Physiology - February 15, 2013 Category: Gastroenterology Authors: Cao, W., Tian, W., Hong, J., Li, D., Tavares, R., Noble, L., Moss, S. F., Resnick, M. B. Tags: CALL FOR PAPERS Source Type: research

934 Immune Factors Involved in the Promotion of Esophageal Adenocarcinoma As Defined by siRNA Library Screening
Source: Gastroenterology - May 1, 2014 Category: Gastroenterology Authors: Fiona Behan, Shane P. Duggan, Catherine Garry, Sinead Phipps, Dermot Kelleher Source Type: research

Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma
Conclusions The enhanced expression of PHD3 might likely contribute to the poor neovascularization and affect the biological characterization in PDAC cancer cells.
Source: Journal of Gastroenterology - December 26, 2014 Category: Gastroenterology Source Type: research

Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner
Conclusions Our results provide novel evidence that tumorigenicity associated with H. pylori infection is linked to inhibition of p53 protein by CagA. We propose a model in which CagA-induced degradation of p53 protein is determined by a relative level of p14ARF. In cells in which p14ARF levels were decreased due to hypermethylation or deletion of the p14ARF gene, H. pylori efficiently degraded p53, whereas p53 is protected in cells expressing high levels of p14ARF.
Source: Gut - June 9, 2015 Category: Gastroenterology Authors: Wei, J., Noto, J. M., Zaika, E., Romero-Gallo, J., Piazuelo, M. B., Schneider, B., El-Rifai, W., Correa, P., Peek, R. M., Zaika, A. I. Tags: Stomach and duodenum, Pancreatic cancer Helicobacter pylori Source Type: research

Reduction of prostaglandin transporter predicts poor prognosis associated with angiogenesis in gastric adenocarcinoma
ConclusionsPGT expression is an independent predictor of poor survival and is associated with tumor angiogenesis in gastric adenocarcinoma. This article is protected by copyright. All rights reserved.
Source: Journal of Gastroenterology and Hepatology - August 6, 2015 Category: Gastroenterology Authors: Shogo Takeda, Tetsuya Tanigawa, Toshio Watanabe, Hiroshi Tatsuwaki, Yuji Nadatani, Koji Otani, Yasuaki Nagami, Fumio Tanaka, Noriko Kamata, Hirokazu Yamagami, Masatsugu Shiba, Kazunari Tominaga, Yasuhiro Fujiwara, Kazuya Muguruma, Masaichi Ohira, Kosei Hi Tags: Original Article ‐ Gastroenterology (Experimental) Source Type: research

Long non-coding RNAs era in liver cancer.
Authors: Guerrieri F Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies leading to high mortality rates in the general population and the sixth most common cancer worldwide. HCC is characterized by deregulation of multiple genes and signalling pathways. These genetic effects can involve both protein coding genes as well as non-coding RNA genes. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nt, constituting a subpopulation of ncRNAs. Their biological effects are not well understood compared to small non-coding RNA (microRNAs), but they have been recently recognized to exe...
Source: World Journal of Hepatology - August 12, 2015 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Linc00675 is a novel marker of short survival and recurrence in patients with pancreatic ductal adenocarcinoma.
CONCLUSION: Linc00675 may function as an oncogene during PDAC development, and its expression is an independent predictor of unfavorable prognosis in patients with PDAC. PMID: 26309360 [PubMed - as supplied by publisher]
Source: World Journal of Gastroenterology : WJG - August 21, 2015 Category: Gastroenterology Authors: Li DD, Fu ZQ, Lin Q, Zhou Y, Zhou QB, Li ZH, Tan LP, Chen RF, Liu YM Tags: World J Gastroenterol Source Type: research