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Cancer: Brain Cancers
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Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer's disease
Biomed Pharmacother. 2023 Sep 11;167:115450. doi: 10.1016/j.biopha.2023.115450. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) plays a critical role in determining the effectiveness of systemic treatments for brain diseases. Over the years, several innovative approaches in BBB opening and drug delivery have been developed and progressed into clinical testing phases, including focused ultrasound (FUS) with circulating microbubbles, mannitol-facilitated delivery of anti-neoplastic drugs, receptor-mediated transcytosis (RMT) by antibody-drug conjugates (ADCs), and viral vectors for gene therapy. We provided a com...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Gefei Song Pierce Plumlee Ju Young Ahn Stephen Tc Wong Hong Zhao Source Type: research
Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score
We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein-(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)-(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 ...
Source: Cellular and Molecular Neurobiology - September 13, 2023 Category: Cytology Authors: Luca Zanin Alexandra Sachkova Pier Paolo Panciani Veit Rohde Marco Maria Fontanella Bawarjan Schatlo Source Type: research
The Prognostic and Functional Impact of Sprouty 2 Expression in Non-small Cell Lung Cancer
CONCLUSION: Spry2 expression was lower in tumor tissues than in normal lung parenchyma. Increased expression of Spry2 is associated with poor prognosis. There were no significant associations between epidermal growth factor receptor, anaplastic lymphoma kinase, or c-ros oncogene 1 rearrangement and Spry2 expression. Despite the absence of KRAS mutational analysis, the clinical and epidemiological features of patients suggested that KRAS mutation might be an underlying determinant factor of the functional role of Spry2 in non-small cell lung cancer.PMID:37700432 | DOI:10.1097/COC.0000000000001044
Source: Clinical Lung Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Yusuf Acikgoz Fatma Unal Yildirim Selin Akturk Esen Gokhan Ucar Yakup Ergun Oznur Bal Mutlu Dogan Dogan Uncu Source Type: research
Liquid Biopsy in Low-Grade Glioma: A Systematic Review and a Proposal for a Clinical Utility Score
We examined each biomarker classifying them by CUS and Level of Evidence (LOE). We identified four classes of biomarkers: (1). Circulating protein-(a) vitronectin discriminates LGG from HGG (Sn:98%, Sp:91%, CUS: 3, LOE: III), (b) CTLA-4 discriminates LGG from HGG, (cutoff: 220.43 pg/ml, Sn: 82%, Sp: 78%, CUS:3, LOE:III), (c) pre-operative TGF b1 predict astrocytoma (cutoff: 2.52 ng/ml, Sn: 94.9%, Sp: 100%, CUS:3, LOE:VI). (2). micro-RNA (miR)-(a) miR-16 discriminates between WHO IV and WHO II and III groups (AUC = 0.98, CUS:3, LOE: III), (b) miR-454-3p is higher in HGG than in LGG (p = 0.013, CUS:3, LOE: III), (c) miR-210 ...
Source: Cellular and Molecular Neurobiology - September 13, 2023 Category: Cytology Authors: Luca Zanin Alexandra Sachkova Pier Paolo Panciani Veit Rohde Marco Maria Fontanella Bawarjan Schatlo Source Type: research
Innovative Genoceuticals in Human Gene Therapy Solutions: Challenges and Safe Clinical Trials of Orphan Gene Therapy Products
Curr Gene Ther. 2023 Sep 11. doi: 10.2174/1566523223666230911120922. Online ahead of print.ABSTRACTThe success of gene therapy attempts is controversial and inconclusive. Currently, it is popular among the public, the scientific community, and manufacturers of Gene Therapy Medical Products. In the absence of any remedy or treatment options available for untreatable inborn metabolic orphan or genetic diseases, cancer, or brain diseases, gene therapy treatment by genoceuticals and T-cells for gene editing and recovery remains the preferred choice as the last hope. A new concept of "Genoceutical Gene Therapy" by using orphan ...
Source: Current Gene Therapy - September 13, 2023 Category: Genetics & Stem Cells Authors: Rakesh Sharma Source Type: research
Web-based psychoeducational interventions for managing cognitive impairment –a systematic review
ConclusionWeb-based cognitive intervention programs are a new approach to rehabilitation and patient education. The evidence, although scarce, shows that web-based interventions are feasible and support subjective cognitive functioning. However, the literature to date is extremely limited and the quality of the studies is weak. More research with high-quality study designs is needed.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=257315, identifier: CRD42021257315.
Source: Frontiers in Neurology - September 13, 2023 Category: Neurology Source Type: research
DE-UFormer: U-shaped dual encoder architectures for brain tumor segmentation
Phys Med Biol. 2023 Sep 12. doi: 10.1088/1361-6560/acf911. Online ahead of print.ABSTRACTOBJECTIVE: In brain tumor segmentation tasks, the CNN or Transformer is usually acted as the encoder since the encoder is necessary to be used. On one hand, the convolution operation of CNN has advantages of extracting local information although its performance of obtaining global expressions is bad. On the other hand, the attention mechanism of the Transformer is good at establishing remote dependencies while it is lacking in the ability to extract high-precision local information. Either high precision local information or global con...
Source: Physics in Medicine and Biology - September 12, 2023 Category: Physics Authors: Yan Dong Ting Wang Chiyuan Ma Zhenxing Li Ryad Chellali Source Type: research
Brain tumor-related epilepsy management: A Society for Neuro-oncology (SNO) consensus review on current management
Neuro Oncol. 2023 Sep 12:noad154. doi: 10.1093/neuonc/noad154. Online ahead of print.ABSTRACTTumor-related epilepsy (TRE) is a frequent and major consequence of brain tumors. Management of TRE is required throughout the course of disease and a deep understanding of diagnosis and treatment is key to improving quality of life. Gross total resection is favored from both an oncologic and epilepsy perspective. Shared mechanisms of tumor growth and epilepsy exist, and emerging data will provide better targeted therapy options. Initial treatment with antiseizure medications (ASM) in conjunction with surgery and/or chemoradiothera...
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Edward K Avila Steven Tobochnik Sara K Inati Johan A F Koekkoek Guy M McKhann James J Riviello Roberta Rud à David Schiff William O Tatum Jessica W Templer Michael Weller Patrick Y Wen Source Type: research
Machine perfusion in liver transplantation
CONCLUSIONS: In situations where the decision has been made to transplant a liver donated after circulatory death or donated following brain death, end-ischaemic HOPE will provide superior clinically relevant outcomes compared with SCS alone. Specifically, graft survival is improved (high-certainty evidence), serious adverse events are reduced (moderate-certainty evidence), and in donors after circulatory death, clinically relevant ischaemic biliary complications are reduced (high-certainty evidence). There is no good evidence that NMP has the same benefits over SCS in terms of these clinically relevant outcomes. NMP does ...
Source: Cochrane Database of Systematic Reviews - September 12, 2023 Category: General Medicine Authors: Samuel J Tingle Joseph J Dobbins Emily R Thompson Rodrigo S Figueiredo Balaji Mahendran Sanjay Pandanaboyana Colin Wilson Source Type: research
DE-UFormer: U-shaped dual encoder architectures for brain tumor segmentation
Phys Med Biol. 2023 Sep 12. doi: 10.1088/1361-6560/acf911. Online ahead of print.ABSTRACTOBJECTIVE: In brain tumor segmentation tasks, the CNN or Transformer is usually acted as the encoder since the encoder is necessary to be used. On one hand, the convolution operation of CNN has advantages of extracting local information although its performance of obtaining global expressions is bad. On the other hand, the attention mechanism of the Transformer is good at establishing remote dependencies while it is lacking in the ability to extract high-precision local information. Either high precision local information or global con...
Source: Physics in Medicine and Biology - September 12, 2023 Category: Physics Authors: Yan Dong Ting Wang Chiyuan Ma Zhenxing Li Ryad Chellali Source Type: research
Clinical outcome analysis of non-small cell lung cancer patients with brain metastasis receiving metastatic brain tumor resection surgery: a multicenter observational study
Am J Cancer Res. 2023 Aug 15;13(8):3607-3617. eCollection 2023.ABSTRACTBrain metastasis is most common in primary non-small cell lung cancer (NSCLC), and some patients require neurosurgical resection for intracranial disease control. Because advances in systemic therapies for metastatic NSCLC have been developed in the past decade, we aimed to analyze and determine clinical factors associated with the postresection survival of NSCLC patients with brain metastasis who underwent neurosurgery followed by systemic therapy. Between January 2017 and December 2021, data for 93 NSCLC patients with brain metastasis treated with neu...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Ping-Chih Hsu Li-Chung Chiu Ko-Ting Chen Chun-Chieh Wang Chen-Te Wu Chiao-En Wu Ho-Wen Ko Scott Chih-Hsi Kuo Yu-Ching Lin Chin-Chou Wang Cheng-Ta Yang Source Type: research
Overall Survival of Metastatic Prostate Cancer Patients According to Location of Visceral Metastatic Sites
CONCLUSION: In mPCa patients, lung only visceral metastases, especially when associated with lymph node only nonvisceral metastases, portend the best prognosis. Conversely, visceral metastatic sites other than lung portend poor prognosis, regardless of concomitant nonvisceral metastases type.PMID:37690970 | DOI:10.1016/j.clgc.2023.08.004
Source: Clinical Lung Cancer - September 10, 2023 Category: Cancer & Oncology Authors: Stefano Tappero Mattia Luca Piccinelli Reha-Baris Incesu Cristina Cano Garcia Francesco Barletta Simone Morra Lukas Scheipner Andrea Baudo Zhe Tian Stefano Parodi Paolo Dell'Oglio Ottavio de Cobelli Markus Graefen Felix K H Chun Alberto Briganti Nicola Lo Source Type: research
HERTHENA-Lung01, a Phase II Trial of Patritumab Deruxtecan (HER3-DXd) in Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Platinum-Based Chemotherapy
CONCLUSION: After tumor progression with EGFR TKI therapy and PBC in patients with EGFR-mutated NSCLC, HER3-DXd once every 3 weeks demonstrated clinically meaningful efficacy with durable responses, including in CNS metastases. A phase III trial in EGFR-mutated NSCLC after progression on an EGFR TKI is ongoing (HERTHENA-Lung02; ClinicalTrials.gov identifier: NCT05338970).PMID:37689979 | DOI:10.1200/JCO.23.01476
Source: Clinical Lung Cancer - September 10, 2023 Category: Cancer & Oncology Authors: Helena A Yu Yasushi Goto Hidetoshi Hayashi Enriqueta Felip James Chih-Hsin Yang Martin Reck Kiyotaka Yoh Se-Hoon Lee Luis Paz-Ares Benjamin Besse Paolo Bironzo Dong-Wan Kim Melissa L Johnson Yi-Long Wu Thomas John Steven Kao Toshiyuki Kozuki Erminia Massa Source Type: research
Overall Survival of Metastatic Prostate Cancer Patients According to Location of Visceral Metastatic Sites
CONCLUSION: In mPCa patients, lung only visceral metastases, especially when associated with lymph node only nonvisceral metastases, portend the best prognosis. Conversely, visceral metastatic sites other than lung portend poor prognosis, regardless of concomitant nonvisceral metastases type.PMID:37690970 | DOI:10.1016/j.clgc.2023.08.004
Source: Clinical Prostate Cancer - September 10, 2023 Category: Cancer & Oncology Authors: Stefano Tappero Mattia Luca Piccinelli Reha-Baris Incesu Cristina Cano Garcia Francesco Barletta Simone Morra Lukas Scheipner Andrea Baudo Zhe Tian Stefano Parodi Paolo Dell'Oglio Ottavio de Cobelli Markus Graefen Felix K H Chun Alberto Briganti Nicola Lo Source Type: research
Two Sides of The Same Coin: Normal and Tumoral Stem Cells, The Relevance of In Vitro Models and Therapeutic Approaches: The Experience with Zika Virus in Nervous System Development and Glioblastoma Treatment
Int J Mol Sci. 2023 Aug 31;24(17):13550. doi: 10.3390/ijms241713550.ABSTRACTNeural stem cells (NSCs) were described for the first time more than two decades ago for their ability to differentiate into all neural cell lineages. The isolation of NSCs from adults and embryos was carried out by various laboratories and in different species, from mice to humans. Similarly, no more than two decades ago, cancer stem cells were described. Cancer stem cells, previously identified in hematological malignancies, have now been isolated from several solid tumors (breast, brain, and gastrointestinal compartment). Though the origin of th...
Source: Molecular Medicine - September 9, 2023 Category: Molecular Biology Authors: Rosaria Tinnirello Cinzia Maria Chinnici Vitale Miceli Rosalia Bus à Matteo Bulati Alessia Gallo Giovanni Zito Pier Giulio Conaldi Gioacchin Iannolo Source Type: research
