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Cancer: Squamous Cell Carcinoma

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Significant effect of education & income on cancer control: Policy consideration for third world
Conclusions Two points have emerged from this study; that is likely to have the highest impact on cancer control: (1) implementing compulsory education till class VI and (2) Enhancing family income to Rs. 4000/INR per month. These are likely to have a complicated interaction with various procarcinogenic practices and environment and their correction is very likely to reduce the cancer occurrence through prevention.
Source: Clinical Epidemiology and Global Health - March 30, 2016 Category: Epidemiology Source Type: research

Significant effect of education & amp; income on cancer control: Policy consideration for third world
Conclusions Two points have emerged from this study; that is likely to have the highest impact on cancer control: (1) implementing compulsory education till class VI and (2) Enhancing family income to Rs. 4000/INR per month. These are likely to have a complicated interaction with various procarcinogenic practices and environment and their correction is very likely to reduce the cancer occurrence through prevention.
Source: Clinical Epidemiology and Global Health - June 17, 2016 Category: Epidemiology Source Type: research

Evaluation of Potential Risk Factors that contribute to Malignant Transformation of Oral Lichen Planus: A Literature Review.
CONCLUSION: In this evidence base, malignant transformation ranges from 0 to 37% with a mean of 4.59%. The highest rate of malignancy was noted in erythematosus and erosive lesions. In this way, follow-up of OLP patients could be carried out more efficiently and appropriately. CLINICAL SIGNIFICANCE: Oral lichen planus is a premalignant lesion. All types of OLP in any site of oral mucosa must be monitored regularly. PMID: 27659090 [PubMed - in process]
Source: J Contemp Dent Pract - September 25, 2016 Category: Dentistry Authors: Agha-Hosseini F, Sheykhbahaei N, SadrZadeh-Afshar MS Tags: J Contemp Dent Pract Source Type: research

Risks and Benefits of Multimodal Esophageal Cancer Treatments: A Meta-Analysis.
CONCLUSIONS This meta-analysis reveals stark differences in outcomes in patients depending on the type of carcinoma. Patients with squamous cell carcinoma should be educated about the risks and benefits of undergoing multiple therapies. PMID: 28214903 [PubMed - in process]
Source: Medical Science Monitor - February 20, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Huge right ventricular mass lesion associated with genital malignant tumor: a case report
ConclusionsThese data suggest that the tumor in the right ventricle metastasized from the genital organs.
Source: Journal of Medical Case Reports - October 3, 2017 Category: General Medicine Source Type: research

Salivary Chemical Factors in Relation with Oral Cancer in Smokers and Non-Smokers: a Literature Review
Squamous cell carcinoma of oral cavity is of malignant tumors, which causes cancerous complications. DNA damage, mainly because of products of oxidative stress like reactive oxygen species, is a frequent mutagenic that triggers carcinoma. Smoking increases the probability of cancer incidence. Saliva is the first biological medium to interact with external compounds, especially smoking substances. The present study overviews the salivary level of some remarkable compounds in relation with smoking and squamous cell carcinoma.To collect data, English literature was searched in databases including PubMed, ScienceDirect and Goo...
Source: Journal of Dentistry, Shiraz University of Medical Sciences - November 21, 2017 Category: Dentistry Source Type: research

Investigation on the regulatory effect of PGE2 on ESCC cells through the trans-activation of EGFR by EP2 and the relevant mechanism.
CONCLUSIONS: Through cell experiments, we verified that the combination of prostaglandin E2 (PGE2) and EP2, the subtype receptor of PGE2, could trans-activate the epidermal growth factor receptor (EGFR) to regulate the proliferation and invasion capability of esophageal squamous cell carcinoma (ESCC) cells, and secrete and express multiple cytokines, thus discovering the pathological mechanism of inflammation to carcinoma transition in the occurrence of ESCC, and providing the experimental evidence for the search of new target in the treatment of ESCC. ESCC cells can highly express the receptor subtype EP2 of PGE2 that can...
Source: European Review for Medical and Pharmacological Sciences - December 24, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Identification of differentially expressed genes between lung adenocarcinoma and squamous cell carcinoma using transcriber signature analysis.
CONCLUSIONS: Through transcriptome analysis, we identified candidate genes, paired microRNAs and pathways for differentiating LUAD and LUSC, and they can provide novel differential diagnosis and therapeutic strategies for LUAD and LUSC. PMID: 31270041 [PubMed - in process]
Source: Journal of Southern Medical University - June 29, 2019 Category: Universities & Medical Training Authors: Peng S, Li X, Liu Q, Zhang Y, Zou L, Gong X, Wang M, Ma X Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

POLE2 Serves as a Prognostic Biomarker and Is Associated with Immune Infiltration in Squamous Cell Lung Cancer.
CONCLUSIONS Higher expression of POLE2 is a prognosis-related biomarker for worse survival and is negatively associated with immune infiltration in squamous cell lung cancer. PMID: 32304567 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - April 20, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Targeted molecular imaging of head and neck squamous cell carcinoma: a window into precision medicine.
Abstract Tumor biomarkers play important roles in tumor growth, invasion, and metastasis. Imaging of specific biomarkers will help to understand different biological activities, thereby achieving precise medicine for each head and neck squamous cell carcinoma (HNSCC) patient. Here, we describe various molecular targets and molecular imaging modalities for HNSCC imaging. An extensive search was undertaken in the PubMed database with the keywords including "HNSCC," "molecular imaging," "biomarker," and "multimodal imaging." Imaging targets in HNSCC consist of the epidermal growth factor receptor, cluster of differen...
Source: Chinese Medical Journal - May 10, 2020 Category: General Medicine Authors: Wu J, Yuan Y, Tao XF Tags: Chin Med J (Engl) Source Type: research

Established treatment concepts for recurrent or metastatic head and neck squamous cell carcinoma (R/M  HNSSC)
ConclusionThe expression of PD-L1, prior treatment, performance status, local symptoms and tumor burden are the most important factors regarding choice of treatment. Pembrolizumab alone or in combination with chemotherapy can be recommend as the 1st line standard in patients with combined positive score (CPS) ≥20. The choice of therapy in patients with CPS 1-19 and CPS<1 has to be individually evaluated for each patient. Furthermore, TPEx is an encouraging alternative to the EXTREME regimen with less toxicity and improved quality of life.
Source: Memo - Magazine of European Medical Oncology - November 12, 2020 Category: Cancer & Oncology Source Type: research

Performance of 18 F-FDG-PET/CT as a next step in the search of occult primary tumors for patients with head and neck squamous cell carcinoma of unknown primary: a systematic review and meta-analysis
Conclusions18F-FDG PET/CT is useful as a next step in the search of occult primary tumors in HNSCC-UP patients defined by endoscopy with or without CT/MRI. However, in light of the high false-positive proportion, confirmatory histological investigations should be viewed as necessary practice upon positive PET/CT findings.
Source: Clinical and Translational Imaging - May 15, 2021 Category: Radiology Source Type: research

Performance of 18F-FDG-PET/CT as a next step in the search of occult primary tumors for patients with head and neck squamous cell carcinoma of unknown primary: a systematic review and meta-analysis
Conclusions18F-FDG PET/CT is useful as a next step in the search of occult primary tumors in HNSCC-UP patients defined by endoscopy with or without CT/MRI. However, in light of the high false-positive proportion, confirmatory histological investigations should be viewed as necessary practice upon positive PET/CT findings.
Source: Clinical and Translational Imaging - August 1, 2021 Category: Radiology Source Type: research

Photodynamic therapy for squamous cell carcinoma of the head and neck: narrative review focusing on photosensitizers
AbstractThis narrative review aimed to evaluate the effectiveness of PDT in early or advanced squamous cell carcinoma of the head and neck (SCCHN). Scopus, MEDLINE/PubMed, and Embase were searched electronically following the PRISMA protocol. Quality assessment was performed according to JBI, NIH, and AMSTAR protocols. The main outcomes evaluated were treatment response, recurrence, survival, and adverse effects. A total of 49 articles met the search criteria: 43 case series, two cohort studies, two prospective before-after clinical trials, one systematic review, and one meta-analysis. Data from 2121 SCCHN patients were in...
Source: Lasers in Medical Science - December 2, 2021 Category: Laser Surgery Source Type: research

Balstilimab and other immunotherapy for recurrent and metastatic cervical cancer
AbstractRecurrent and metastatic cervical cancer is generally treated by cisplatin, paclitaxel, and bevacizumab with limited benefit this constituting an unmet need. Immune checkpoint inhibitors, namely the inhibitors of programmed death 1 and programmed death ligand 1 have been proved to be efficacious in the treatment of patients with advanced cervical cancer. Recently, a PD-1 inhibitor, pembrolizumab was approved  for such cancer. However, there is much scope of improvement of current outcome. Dual blockade of cytotoxic T lymphocyte-associated protein 4 and PD-1 is an attractive therapeutic approach. It is used in othe...
Source: Medical Oncology - January 29, 2022 Category: Cancer & Oncology Source Type: research