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Total 28070 results found since Jan 2013.

Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays.
In conclusion, the developed yeast target-based screening assays led to the identification of potential caspase-7 activators. A proof of concept is therefore provided for the effectiveness of the yeast assays in the discovery of caspase activators. Additionally, the identified compounds may pave the way for a new class of caspase activators with improved anticancer properties. PMID: 24398107 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - January 4, 2014 Category: Drugs & Pharmacology Authors: Pereira C, Lopes-Rodrigues V, Coutinho I, Neves MP, Lima RT, Pinto M, Cidade H, Vasconcelos MH, Saraiva L Tags: Eur J Pharm Sci Source Type: research

From Cork to Boston: Crossing the Atlantic to treat a brain tumor
By Irene Sege Alisha, Michelle and John. Photo by Sam Ogden Even in its most common form, childhood cancer is rare. Imagine then that the reason your 2-year-old daughter is vomiting and can’t hold her head straight is not a virus, as doctors originally suspected, but an incredibly rare brain tumor. This is precisely what John Savage and Michelle Long of Cork, Ireland, faced in November 2012, when their daughter Alisha Savage was diagnosed with Stage IV atypical teratoid rhabdoid tumors. On Jan. 24, 2014, the family arrived in Boston to have Alisha treated at Dana-Farber/Boston Children’s Cancer and Blood Disorders...
Source: Thrive, Children's Hospital Boston - March 19, 2014 Category: Pediatrics Authors: Guest Blogger Tags: All posts Atypical teratoid rhabdoid tumors (AT/RT) Brain Tumor Center Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Mark Kieran our patients' stories Susan Chi Source Type: news

Physiologic and psychological symptoms experienced by adults with acute leukemia: an integrative literature review.
Conclusions: Knowledge regarding the symptoms experienced by adults undergoing treatment is being slowly evaluated. However, to better understand and subsequently manage these symptoms, longitudinal research examining the symptom trajectories in this population is needed.Implications for Nursing: Additional investigation into symptom characteristics will facilitate the development of tailored interventions to manage the temporal characteristics of symptoms for this population. PMID: 24769593 [PubMed - in process]
Source: Oncology Nursing Forum - May 1, 2014 Category: Nursing Authors: Albrecht TA Tags: Oncol Nurs Forum Source Type: research

Obinutuzumab: A Novel Anti-CD20 Monoclonal Antibody for Previously Untreated Chronic Lymphocytic Leukemia.
CONCLUSION: Obinutuzumab in combination with chlorambucil is a safe and effective new treatment option for previously untreated elderly CLL patients. It should become the new preferred therapy for these patients with significant comorbidities who are not candidates for fludarabine-based therapy. PMID: 25037849 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - July 18, 2014 Category: Drugs & Pharmacology Authors: Shah A Tags: Ann Pharmacother Source Type: research

Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria.
CONCLUSIONS: This review has detected an absence of evidence for eculizumab compared with placebo for treating paroxysmal nocturnal hemoglobinuria (PNH), in terms of overall survival, nonfatal thrombotic events, transformation to myelodysplastic syndrome and acute myelogenous leukemia, and development and recurrence of aplastic anemia on treatment. Current evidence indicates that compared with placebo, eculizumab increases health-related quality of life and increases transfusion independence. During the execution of the included trial, no patients died. Furthermore, the intervention seems to reduce fatigue and withdrawals ...
Source: Cochrane Database of Systematic Reviews - October 30, 2014 Category: Journals (General) Authors: Martí-Carvajal AJ, Anand V, Cardona AF, Solà I Tags: Cochrane Database Syst Rev Source Type: research

Ws3-5 * allogeneic hematopoietic cell transplantation for adult t cell leukemia/lymphoma
In conclusion, continuous clinical studies are needed to optimize the SCT for ATL.
Source: Annals of Oncology - October 19, 2014 Category: Cancer & Oncology Authors: Choi, I., Uike, N. Tags: Workshop 3: ' Progress in basic research and treatment for ATL Source Type: research

Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome. Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437 Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-1564. E-mail: cidlows1@niehs.nih.gov We thank X. Xu (Integrative Bioinformatic...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research

Forget About Your New Year's Resolutions. Just Put Your Vices To Good Use
It’s your vice. Your Achilles' heel. Your thing. But it’s a thing you can’t -- you won’t -- give up, even if resolution season is here. Hey, we’re not here to judge. In fact, we have some ways to make you feel pretty good while you might be feeling a tiny bit bad. Here are ways to turn your vices into something that's productive and helps support important causes. If You’re Always Jonesing For A Cup Of Joe… Sniff Out Some Beans That Support Needy Communities You probably don’t stand a chance against the snooze button without a cup of coffee. So if you must indulge (and yeah, we know -- it's a mus...
Source: Healthy Living - The Huffington Post - January 2, 2015 Category: Consumer Health News Source Type: news

PubMed misses the big picture when it comes to nutrition
As medical librarians, we’re certainly the first to say that PubMed is a superb database, elegantly crafted at the National Library of Medicine to do fast and efficient searches for almost all medical and health subjects. Much of the power of PubMed is that it makes it possible to search broad subjects easily. When the user searches “cancer,” for example, PubMed quickly finds thousands of citations on all types of cancer, from melanoma to leukemia, whether the word “cancer” appears in the citation or not. Likewise, a search for “antidepressants” finds articles on all specific types of antidepressants. The see...
Source: Kevin, M.D. - Medical Weblog - February 26, 2015 Category: Journals (General) Authors: Tags: Conditions Obesity Source Type: blogs

Breastfeeding and Childhood Leukemia Incidence: A Meta-analysis and Systematic Review.
Conclusions and Relevance: Breastfeeding is a highly accessible, low-cost public health measure. This meta-analysis that included studies not featured in previous meta-analyses on the subject indicates that promoting breastfeeding for 6 months or more may help lower childhood leukemia incidence, in addition to its other health benefits for children and mothers. PMID: 26030516 [PubMed - as supplied by publisher]
Source: Cancer Control - June 1, 2015 Category: Cancer & Oncology Authors: Amitay EL, Keinan-Boker L Tags: JAMA Pediatr Source Type: research

Idelalisib: A Novel PI3Kδ Inhibitor for Chronic Lymphocytic Leukemia.
CONCLUSION: Idelalisib in combination with rituximab is a safe and effective new treatment option for patients with relapsed CLL, including those with poor prognostic factors. As the results from various ongoing studies become available, the role of idelalisib will likely continue to expand. PMID: 26185276 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - July 16, 2015 Category: Drugs & Pharmacology Authors: Shah A, Mangaonkar A Tags: Ann Pharmacother Source Type: research

Characteristic clinical features of Aspergillus appendicitis: Case report and literature review.
Abstract This work aims to facilitate diagnosing Aspergillus appendicitis, which can be missed clinically due to its rarity, by proposing a clinical pentad for Aspergillus appendicitis based on literature review and one new case. The currently reported case of pathologically-proven Aspergillus appendicitis was identified by computerized search of pathology database at William Beaumont Hospital, 1999-2014. Prior cases were identified by computerized literature search. Among 10980 pathology reports of pathologically-proven appendicitis, one case of Aspergillus appendicitis was identified (rate = 0.01%). A young boy ...
Source: World Journal of Gastroenterology : WJG - November 28, 2015 Category: Gastroenterology Authors: Gjeorgjievski M, Amin MB, Cappell MS Tags: World J Gastroenterol Source Type: research

Granulocyte and granulocyte-macrophage colony stimulating factors for newly diagnosed patients with myelodysplastic syndromes.
CONCLUSIONS: Although we identified seven trials with a total number of 486 patients, and two unpublished, prematurely finished studies, this systematic review mainly shows that there is a substantial lack of data, which might inform the use of G-CSF and GM-CSF for the prevention of infections, prolonging of survival and improvement of quality of life. The impact on progression to AML remains unclear. PMID: 26880256 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 16, 2016 Category: Journals (General) Authors: Hutzschenreuter F, Monsef I, Kreuzer KA, Engert A, Skoetz N Tags: Cochrane Database Syst Rev Source Type: research

QUESTION 1: Should we be using bisphosphonates for osteonecrosis complicating childhood acute lymphoblastic leukaemia?
Scenario A 15-year-old girl with acute lymphoblastic leukaemia (ALL) who has been on high-dose steroids develops a painful right hip. Although plain radiographs are normal, there are changes indicating osteonecrosis on MRI. You remember that osteonecrosis can develop after use of high-dose steroids, and recall a discussion with an orthopaedic surgeon who had said he thought bisphosphonates could help in some patients. You wonder whether they would be of value for your patient. Structured clinical question In a patient with osteonecrosis, presumed secondary to steroid use, in childhood ALL (patient), what is the evidence fo...
Source: Archives of Disease in Childhood - February 18, 2016 Category: Pediatrics Authors: Amin, N. L., James, R. M., Phillips, R. Tags: ADC Archimedes, Oncology, Immunology (including allergy), Pain (neurology), Hypertension, Radiology, Rheumatology, Clinical diagnostic tests, Radiology (diagnostics) Source Type: research

Benzene exposure is associated with epigenetic changes (Review).
Authors: Fenga C, Gangemi S, Costa C Abstract Benzene is a volatile aromatic hydrocarbon solvent and is known as one of the predominant air pollutants in the environment. Chronic exposure to benzene is known to cause aplastic anemia and increased risk of acute myelogenous leukemia in humans. Although the mechanisms by which benzene causes toxicity remain to be fully elucidated, it is widely accepted that its metabolism is crucial to its toxicity, with involvement of one or more reactive metabolites. Novel approaches aimed at evaluating different mechanisms by which benzene can impact on human health by altering gen...
Source: Molecular Medicine Reports - March 6, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research