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Cancers, Vol. 15, Pages 4689: Estrogen Receptor Signaling in Breast Cancer
rzej Stepulak
Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens’ synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modul...
Source: Cancers - September 23, 2023 Category: Cancer & Oncology Authors: Paulina Miziak Marzena Baran Ewa B łaszczak Alicja Przybyszewska-Podstawka Joanna Ka łafut Jolanta Smok-Kalwat Magdalena Dmoszy ńska-Graniczka Micha ł Kiełbus Andrzej Stepulak Tags: Review Source Type: research
AstraZeneca Surges As It Takes A Shot At Gilead ' s Second-Biggest Cancer Drug
and Daiichi Sankyo said Friday their breast cancer treatment outperformed chemotherapy in a Phase 3 study, and AZN stock jumped to its 50-day line. The companies are in the antibody drug conjugate, or ADC, space with a medicine called datopotamab deruxteca. ADCs are like smart bombs, targeting…#daiichisankyo #azn #astrazeneca #adc #marketsmithcom #trodelvy #gileadsciences #gild #isi #umerraffat
Source: Reuters: Health - September 22, 2023 Category: Consumer Health News Source Type: news
what med schools would you recommend with ucat 2530 B2 and gcses 4 9s,4 8s, a 7
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Source: The Student Room - September 22, 2023 Category: Universities & Medical Training Authors: ceezee Tags: Medicine Source Type: forums
Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Clinical Breast Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research
Initial experience with an electron FLASH research extension (FLEX) for the Clinac system
CONCLUSION: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.PMID:37735808 | DOI:10.1002/acm2.14159
Source: Clinical Breast Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Kyuhak Oh Kyle J Gallagher Megan Hyun Diane Schott Sarah Wisnoskie Yu Lei Samuel Hendley Jeffrey Wong Shuo Wang Brendan Graff Christopher Jenkins Frank Rutar Md Ahmed Joshua McNeur Jeffrey Taylor Marty Schmidt Lasitha Senadheera Wendy Smith Donald Umstadt Source Type: research
Targeting the NAD+ Salvage Pathway: Synergistic Therapeutic Strategy for ER+ Metastatic Breast Cancer
Endocrinology. 2023 Sep 20:bqad140. doi: 10.1210/endocr/bqad140. Online ahead of print.NO ABSTRACTPMID:37738166 | DOI:10.1210/endocr/bqad140
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Rebecca B Riggins Suman Ranjit Source Type: research
Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Clinical Genitourinary Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research
Characterization of the Tumor Microenvironment of De Novo Oligometastatic Breast Cancer in a Nationwide Cohort
CONCLUSION: We identified tumor and ECM features in the primary tumor of patients with de novo OMBC that were associated with long-term survival. Our data should be validated in other patients with OMBC before they can be used in clinical practice.PMID:37738542 | DOI:10.1200/PO.22.00670
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Tessa G Steenbruggen Denise M Wolf Bram Thijssen Joyce Sanders Sten Cornelissen Roberto Salgado Lorenza Mittempergher Rajith Bhaskaran Annegien Broeks Esther H Lips Sabine Siesling Gabe S Sonke Hugo M Horlings Laura J van 't Veer Source Type: research
Untargeted serum metabolomic profiles and breast density in young women
CONCLUSION: Our results suggest an inverse association of branched chain amino acids with %DBV. Larger studies in diverse populations are needed.PMID:37737303 | DOI:10.1007/s10552-023-01793-w
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seungyoun Jung Sarah Silva Cher M Dallal Erin LeBlanc Kenneth Paris John Shepherd Linda G Snetselaar Linda Van Horn Yuji Zhang Joanne F Dorgan Source Type: research
The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1
In conclusion, our findings reveal the mechanism of tumorigenic miR-429 in TNBC, which paves the way for target therapies translation in clinical settings.PMID:37737712 | DOI:10.18632/aging.205051
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Yao Li Xue Meng Yuqing Luo Shuai Luo Jin Li Jiafei Zeng Xiang Huang Jinjing Wang Source Type: research
Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research
FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis
In this study, we identified positive as well as negative regulators of Moesin. Our study reveals that Moesin is a cellular target of F-box protein FBXW2. We showed that FBXW2 suppresses breast cancer progression through directing proteasomal degradation of Moesin. In contrast, AKT kinase plays an important role in oncogenic function of Moesin by protecting it from FBXW2-mediated proteasomal degradation. Mechanistically, AKT phosphorylates Moesin at Thr-558 and thereby prevents its degradation by FBXW2 via weakening the association between FBXW2 and Moesin. Further, accumulated Moesin prevents FBXW2-mediated degradation of...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Ganesh Kumar Barik Osheen Sahay Anindya Mukhopadhyay Rajesh Kumar Manne Sehbanul Islam Anup Roy Somsubhra Nath Manas Kumar Santra Source Type: research
Dose delivery reproducibility for PBS proton treatment of breast cancer patients with and without mask immobilization
In this study, we retrospecti...
Source: Radiation Oncology - September 22, 2023 Category: Cancer & Oncology Authors: Yixiu Kang, Martin Bues, Michele Y. Halyard, Lisa A. McGee, Tamara Z. Vern-Gross, William W. Wong, Sameer R. Keole, Carlos Vargas, Sarah E. James, Safia K. Ahmed, James P. Archuleta, Ana K. Ridgway, Pedro R. Lara and Mirek Fatyga Tags: Research Source Type: research
Unveiling the vulnerabilities of synthetic lethality in triple-negative breast cancer
AbstractTriple-negative breast cancer (TNBC) is the most invasive molecular subtype of breast cancer (BC), accounting for about nearly 15% of all BC cases reported annually. The absence of the three major BC hormone receptors, Estrogen (ER), Progesterone (PR), and Human Epidermal Growth Factor 2 (HER2) receptor, accounts for the characteristic “Triple negative” phraseology. The absence of these marked receptors makes this cancer insensitive to classical endocrine therapeutic approaches. Hence, the available treatment options remain solemnly limited to only conventional realms of chemotherapy and radiation therapy. More...
Source: Clinical and Translational Oncology - September 21, 2023 Category: Cancer & Oncology Source Type: research
Identification of a TRP channel-related risk model for predicting prognosis and therapeutic effects of patients with hepatocellular carcinoma
CONCLUSIONS: We successfully established a highly accurate prognostic model for predicting overall survival and therapeutic effects using TRP channel-related genes.PMID:37733242 | DOI:10.1007/s00432-023-05394-7
Source: Clinical Breast Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Chong Pang Zhe Xu Jilong Han Fujun Li Hongyan Zhu Jiaqi Zhang Dong Wang Xundi Xu Source Type: research
