Cancers, Vol. 15, Pages 4689: Estrogen Receptor Signaling in Breast Cancer
Cancers, Vol. 15, Pages 4689: Estrogen Receptor Signaling in Breast Cancer
Cancers doi: 10.3390/cancers15194689
Authors:
Paulina Miziak
Marzena Baran
Ewa Błaszczak
Alicja Przybyszewska-Podstawka
Joanna Kałafut
Jolanta Smok-Kalwat
Magdalena Dmoszyńska-Graniczka
Michał Kiełbus
Andrzej Stepulak
Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens’ synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modulators, is discussed. As a consequence, the challenges associated with the resistance to these therapies resulting from acquired ER mutations and potential strategies to overcome them are the critical point for the new treatment strategies’ development.
Source: Cancers - Category: Cancer & Oncology Authors: Paulina Miziak Marzena Baran Ewa B łaszczak Alicja Przybyszewska-Podstawka Joanna Ka łafut Jolanta Smok-Kalwat Magdalena Dmoszy ńska-Graniczka Micha ł Kiełbus Andrzej Stepulak Tags: Review Source Type: research