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Cancer: Pheochromocytoma

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Total 47 results found since Jan 2013.

Takotsubo-Like Myocardial Dysfunction in Ischemic Stroke Clinical Sciences
This study included 23 patients (0.42%). The mean age was 70.7±13.9 years, with predominance of women (73.9%) and typical pattern of Takotsubo-like myocardial dysfunction (91.3%). They were associated with short-term poor functional outcomes, including high mortality, neurological deterioration, and functional status at discharge, compared with those without (39.1% versus 2.4%, 47.8% versus 7.4%; and median [interquartile range], 5 [5–6] versus 3 [2–4]; all P
Source: Stroke - October 23, 2016 Category: Neurology Authors: Jung, J.-M., Kim, J.-G., Kim, J. B., Cho, K.-H., Yu, S., Oh, K., Kim, Y.-H., Choi, J.-Y., Seo, W.-K. Tags: Risk Factors, Cardiomyopathy, Prognosis, Mortality/Survival, Ischemic Stroke Original Contributions Source Type: research

MicroRNA-424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke
Exp Ther Med. 2021 Dec;22(6):1453. doi: 10.3892/etm.2021.10888. Epub 2021 Oct 15.ABSTRACTCerebral ischemic stroke is the primary cause of stroke-associated mortality and disability, and current therapeutic options are limited and ineffective. The present study aimed to investigate the potential of apoptotic therapy and the role of microRNA (miR)-424 in cerebral ischemic stroke. PC12 cells, a cloned cell line from rat adrenal pheochromocytoma, were treated with CoCl2 to construct a cellular ischemia model. mRNA and protein levels of programmed cell death protein 4 (PDCD4), Bcl-2, Bax, caspase-3, PI3K and AKT were evaluated ...
Source: Experimental and Therapeutic Medicine - November 1, 2021 Category: General Medicine Authors: Hou-Wei Ren Bin Gu Yue-Zhan Zhang Ting Guo Qian Wang Yue-Qin Shen Jun Wang Source Type: research

Pheochromocytoma causing cardiomyopathy, ischemic stroke and acute arterial thrombosis: a case report and review of the literature.
We present a case of multiple, rare clinical complications of pheochromocytoma occurring in the same patient and the review of literature of these complications. PMID: 23513638 [PubMed - indexed for MEDLINE]
Source: Connecticut Medicine - February 1, 2013 Category: Journals (General) Authors: Vindenes T, Crump N, Casenas R, Wood K Tags: Conn Med Source Type: research

LncRNA ANRIL protects against oxygen and glucose deprivation (OGD)-induced injury in PC-12 cells: potential role in ischaemic stroke.
In conclusion, lncRNA ANRIL alleviated OGD-induced PC-12 cell injury as evidenced. PI3K/AKT pathway might be involved in this regulating progression. PMID: 31174432 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - June 10, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Acute upper extremity arterial thrombosis and stroke in an unresected pheochromocytoma
Pheochromocytoma is a rare cause of hypertension in the general population. Only isolated reports show an association with acute obstructive arterial thrombosis. A 50-year-old chronically noncompliant woman with a known unresected pheochromocytoma presented to the emergency department with ataxia. Imaging confirmed a right-sided ischemic stroke. During her hospital stay, the patient developed signs consistent with acute right upper extremity ischemia resulting from occlusion in the distal right subclavian, axillary, and proximal brachial arteries. Emergent open thrombectomy was successfully performed. In patients with an u...
Source: Journal of Vascular Surgery - March 13, 2013 Category: Surgery Authors: Sameer Kaiser, John Chronakos, Alan M. Dietzek Tags: Case reports Source Type: research

Beneficial Effect of Astragalosides on Stroke Condition Using PC12 Cells under Oxygen Glucose Deprivation and Reperfusion.
In this study, the direct effect of AST against oxygen and glucose deprivation (OGD) including neuronal injury and the underlying mechanisms in vitro were investigated. 5 h OGD followed by 24 h of reperfusion [adding back oxygen and glucose (OGD-R)] was used to induce in vitro ischemia reperfusion injury in differentiated rat pheochromocytoma PC12 cells. AST (1, 100, and 200 µg/mL) were added to the culture after 5 h of the OGD ischemic insult and was present during the reoxygenation phases. A key finding was that OGD-R decreased cell viability, increased lactate dehydrogenase, increased reactive oxygen species, apopt...
Source: Cellular and Molecular Neurobiology - May 8, 2014 Category: Cytology Authors: Chiu BY, Chang CP, Lin JW, Yu JS, Liu WP, Hsu YC, Lin MT Tags: Cell Mol Neurobiol Source Type: research

Flavonoids Isolated from Rumex aquaticus Exhibit Neuroprotective and Neurorestorative Properties by Enhancing Neurite Outgrowth and Synaptophysin.
In this study, the isolation of two flavonoids - quercetin-3-O-galactoside (1) and quercetin-3-O-arabinoside (2) - from Rumex aquaticus (western dock) and their neuroprotective effects were reported in the oxygen-glucose deprivation (OGD) model of in vitro ischemia using rat pheochromocytoma (PC12) cell line. Bioassay-guided fractionation of the ethyl-acetate extract of Rumex aquaticus L. afforded the isolation of compounds 1 and 2. The structures of compounds were established on the basis of spectroscopic analyses (UV, mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). Both compounds were isolated f...
Source: CNS and Neurological Disorders Drug Targets - October 23, 2014 Category: Drugs & Pharmacology Authors: Orbán-Gyapai O, Raghavan A, Vasas A, Forgo P, Hohmann J, Shah ZA Tags: CNS Neurol Disord Drug Targets Source Type: research

Downregulation of ELAVL1 attenuates ferroptosis-induced neuronal impairment in rats with cerebral ischemia/reperfusion via reducing DNMT3B-dependent PINK1 methylation
ConclusionELAVL1 plays a critical role in protecting against ferroptosis-induced cerebral I/R and subsequent brain damage via DNMT3B/PINK1 axis, thus providing a new potential target for ischemic stroke treatment.
Source: Metabolic Brain Disease - September 29, 2022 Category: Neurology Source Type: research

Effects of SARA on oxygen-glucose deprivation in PC12 cell line.
Abstract Ischemic stroke is a major composition of cerebrovascular disease, seriously threatening to human health in the world. Activin A (ActA), belonging to transforming growth factor-beta (TGF-β) super family, plays an important role in the hypoxic-ischemic brain injury through ActA/Smads pathway. While as an essential phosphorylation assistor in TGF-β signaling, the functions and mechanisms of smad anchor for receptor activation (SARA) in ischemic brain injury remain poorly understood. To solve this problem and explore the pathological processes of ischemic stroke, we used an Oxygen-Glucose deprivation (OGD)...
Source: Neurochemical Research - May 1, 2013 Category: Neuroscience Authors: Wang JQ, He JT, Du ZW, Li ZS, Liu YF, Mang J, Xu ZX Tags: Neurochem Res Source Type: research

Acute hypertension: a systematic review and appraisal of guidelines.
CONCLUSION: NHLBI and ESH/ESC guidelines are high quality and provide similar recommendations for management of asymptomatic acute hypertensive episodes and hypertensive emergencies. Additional research is needed to inform clinical practice guidelines for this common condition. PMID: 25598731 [PubMed]
Source: Ochsner Journal - November 18, 2015 Category: Journals (General) Tags: Ochsner J Source Type: research

L-NBP, a multiple growth factor activator, attenuates ischemic neuronal impairments possibly through promoting neuritogenesis
Publication date: Available online 7 January 2019Source: Neurochemistry InternationalAuthor(s): Yuming Zhao, Dongmei Liu, Jiang Li, XiaoJie Zhang, Xiaoliang WangAbstractIn China, L-3-n-butylphthalide (L-NBP) showed promising pharmacological actions in stroke treatment. Analyzing the characteristics of L-NBP might provide valuable hints for new drug design. The current study is aimed to determine the effects of L-NBP on neuritogenesis and further to elucidate the neuronal protection against stroke impairment in vitro. L-NBP was applied to rat pheochromocytoma PC12 cells and cultured rat cortical neurons under the normoxic...
Source: Neurochemistry International - January 7, 2019 Category: Neuroscience Source Type: research

Screening for phaeochromocytoma in patients with acute cerebrovascular disease: Is it necessary?
CONCLUSION: We noted that CATS/METS were elevated in one-third of patients, especially in patients with high systolic blood pressure. Increase in CATS/METS should be appropriately followed up with repeat testing. Since false elevation in CATS/METS has been reported in cerebrovascular disease, screening for phaeochromocytoma is best deferred for a month. PMID: 32860372 [PubMed - as supplied by publisher]
Source: Malaysian Journal of Pathology - August 30, 2020 Category: Pathology Tags: Malays J Pathol Source Type: research