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Brigatinib induced photosensitivity
We present a case of blistering dermatitis suspected secondary to brigatinib.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: C. Yie, J. Rosenblum, E. Banta, S. Mawhirt Tags: M068 Source Type: research

Allergic Contact Dermatitis To Fentanyl TTS With Good Tolerance To Systemic Fentanyl.
CONCLUSION: We present the case of allergic contact dermatitis (ACD) due to hypersensitivity to fentanyl with good tolerance to buprenorphine. Positive PT in this patient suggests a type IV hypersensitivity mechanism. Allergic reactions to opioids are frequently immediate, but delayed reactions could appear, especially when the drug is administered topically. PMID: 31131754 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - May 29, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

Validation of a 16th Century Traditional Chinese Medicine Use of Ginkgo biloba as a Topical Antimicrobial
This study aimed to examine the traditional use of Ginkgo seeds as topical treatment for skin disorders for potential antibacterial efficacy. This is the first study to test and compare the antibacterial activity of various Ginkgo seed extracts on skin pathogens. In this work, we confirmed the ethnomedicinal importance of seeds in the treatment of skin diseases. As reported in the Compendium of Materia Medica Ben Cao Gang Mu, only the seeds were used for medicinal uses, especially as a topical treatment for skin infections. Moreover, our study validates the antimicrobial activity of the seed (i.e., seed coats and immature...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation
This study was supported by grants from GSK and the UK Medical Research Council (U105178805). Conflict of Interest Statement AM has grant funding from GSK and AstraZeneca/MedImmune. MB, DJ, AP, DT, and AvO are employees of GSK. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are grateful to the Ares staff, genotyping facility, and flow cytometry core for their technical assistance. We thank Jen Walker for advice on the manuscript. Supplementary Material The Supplem...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells
This study was provided by the Canadian Institutes of Health Research and the Manitoba Health Research Council. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Sprent J, Kishimoto H. The thymus and central tolerance. Philos Trans R Soc Lond B Biol Sci. (2001) 356:609–16. doi: 10.1098/rstb.2001.0846 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Sakaguchi S, Wing K, Miyara M. Regulatory T cells - a brief history and perspective...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Elemental Sulfur Use and Associations with Pediatric Lung Function and Respiratory Symptoms in an Agricultural Community (California, USA)
Conclusions: This study suggests that elemental sulfur use, allowed in both organic and conventional farming, in close proximity to residential areas, may adversely affect children’s respiratory health. https://doi.org/10.1289/EHP528 Received: 19 May 2016 Revised: 05 May 2017 Accepted: 09 May 2017 Published: 14 August 2017 Address correspondence to R. Raanan, Center for Environmental Research and Children’s Health (CERCH), University of California, Berkeley, School of Public Health, 1995 University Ave., Suite 265, Berkeley, CA 94704 USA. Telephone: (510) 642-9431. Email: rachelraananrr@gmail.com Supplemental Ma...
Source: EHP Research - August 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Niacin intake and incident adult-onset atopic dermatitis in women
Adult-onset atopic dermatitis (AD) is a recognized entity,1 but little is known about risk factors for its development. Results from a randomized controlled trial of coated oral nicotinamide tablets for the prevention of skin cancer found that nicotinamide modestly decreased transepidermal water loss (TEWL), a measure of epidermal barrier integrity, among participants.2 Nicotinamide is a derivative of niacin (vitamin B3, nicotinic acid), a nutrient found in many foods and supplements, including B vitamin complex and multivitamins.
Source: Journal of Allergy and Clinical Immunology - January 19, 2017 Category: Allergy & Immunology Authors: Aaron M. Drucker, Wen-Qing Li, Min Kyung Park, Tricia Li, Abrar A. Qureshi, Eunyoung Cho Tags: Letter to the Editor Source Type: research

ARRY-502, a potent, selective, oral CRTh2 antagonist reduces Th2 mediators in patients with mild to moderate Th2-driven asthma
Asthma and other allergic diseases are associated with mast cell activation and prostaglandin D2 (PGD2) generation. PGD2 exerts pro-inflammatory activity via chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2). The safety and efficacy of CRTh2 antagonist ARRY-502 was studied in mild atopic asthmatic adults in a double-blind, placebo-controlled 4 week phase 2a study. Enrolled patients were free of inhaled corticosteroids with an FEV1% predicted of 60-85%. Potential participants were screened and randomized to receive 200 mg BID ARRY-502 (n = 93) or matching placebo (n = 91). In patients with elevated...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Wenzel, S., Chantry, D., Eberhardt, C., Hopkins, R., Saunders, M., Anderson, L., Aitchinson, R., Bell, S., Izuhara, K., Ono, J., Burgess, L. Tags: 5.3 Allergy and Immunology Source Type: research

Evaluation of micronuclear frequencies in both circulating lymphocytes and buccal epithelial cells of patients with oral lichen planus and oral lichenoid contact reactions
ConclusionsMN scores do not distinguish OLP from OLCR when using buccal smears but significant differences were observed in peripheral lymphocytes. OLP and OLCR both demonstrated significantly higher MN frequencies in both buccal and circulating lymphocytes cells, compared with healthy controls. MN assesment in both buccal epithelial cells and circulating lymphocytes may serve as a potential biomarker tool for evaluating any cancer risk in OLP and OLCR.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - July 31, 2013 Category: ENT & OMF Authors: A. Saruhanoğlu, S. Ergun, M. Kaya, S. Warnakulasuriya, M. Erbağcı, Ş. Öztürk, E. Deniz, S. Özel, K. Çefle, Ş. Palanduz, H. Tanyeri Tags: Original Article Source Type: research