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Comorbid diseases and conditions in people with HIV in the UK
CONCLUSIONS: PLHIV in the UK were at a higher risk of developing a number of comorbid conditions, highlighting the need for regular attendance of health reviews such as the annual health reviews recommended by the British HIV Associations (BHIVA) quality standard for care, which are currently not uniformly conducted.PMID:34761727 | DOI:10.1080/03007995.2021.2003671
Source: Current Medical Research and Opinion - November 11, 2021 Category: Research Authors: Bethan I Jones Andrew Freedman Melissa J Thomas Celia Villalba-Mendez Leena Sathia Deborah Flanagan Scott Francis Craig J Currie Source Type: research

Books in brief
Nature 499, 7459 (2013). doi:10.1038/499405a Author: Barbara Kiser The US 'war on cancer' begun in 1971 has been an overall failure, argues journalist and cancer survivor Clifton Leaf. Over the past 40 years, he shows, crude deaths of US citizens from cancer have risen by 14%, although those from stroke and other killer
Source: Nature - July 24, 2013 Category: Research Authors: Barbara Kiser Tags: Books and Arts Source Type: research

Transcranial direct current stimulation and repetitive transcranial magnetic stimulation in consultation-liaison psychiatry.
Abstract Patients with clinical diseases often present psychiatric conditions whose pharmacological treatment is hampered due to hazardous interactions with the clinical treatment and/or disease. This is particularly relevant for major depressive disorder, the most common psychiatric disorder in the general hospital. In this context, nonpharmacological interventions could be useful therapies; and, among those, noninvasive brain stimulation (NIBS) might be an interesting option. The main methods of NIBS are repetitive transcranial magnetic stimulation (rTMS), which was recently approved as a nonresearch treatment f...
Source: Braz J Med Biol Res - October 2, 2013 Category: Research Authors: Valiengo LC, Benseñor IM, Lotufo PA, Fraguas R, Brunoni AR Tags: Braz J Med Biol Res Source Type: research

Adiponectin as a routine clinical biomarker.
Abstract Adiponectin is a protein synthesized and secreted predominantly by adipocytes into the peripheral blood. However, circulating adiponectin level is inversely related with body weight, especially visceral fat accumulation. The mechanism of this paradoxical relation remains obscure. Low circulating adiponectin concentrations (hypoadiponectinemia; <4 μg/mL) are associated with a variety of diseases, including dysmetabolism (type 2 diabetes, insulin resistance, hypertension, dyslipidemia, metabolic syndrome, hyperuricemia), atherosclerosis (coronary artery disease, stroke, peripheral artery disease), slee...
Source: Clin Med Res - January 1, 2014 Category: Research Authors: Kishida K, Funahashi T, Shimomura I Tags: Best Pract Res Clin Endocrinol Metab Source Type: research

Genetic & epigenetic approach to human obesity.
Genetic & epigenetic approach to human obesity. Indian J Med Res. 2014 Nov;140(5):589-603 Authors: Rao KR, Lal N, Giridharan NV Abstract Obesity is an important clinical and public health challenge, epitomized by excess adipose tissue accumulation resulting from an imbalance in energy intake and energy expenditure. It is a forerunner for a variety of other diseases such as type-2-diabetes (T2D), cardiovascular diseases, some types of cancer, stroke, hyperlipidaemia and can be fatal leading to premature death. Obesity is highly heritable and arises from the interplay of multiple genes and environme...
Source: Indian J Med Res - November 1, 2014 Category: Research Authors: Rao KR, Lal N, Giridharan NV Tags: Indian J Med Res Source Type: research

A Current Amplifier for Local Coil Pre-amplification of NMR/MRI Signals
The magnetic resonance imaging (MRI) systems are used for a variety of imaging application. The present invention discloses an improving MRI device and method by amplifying signals received by resonant NMR coils of MRI systems. It utilizes positive feedback from low-noise Field-Effect Transistor to amplify the signal current that can be coupled out to receiving loops positioned externally without loss in sensitivity. Therefore, the NMR coil can be flexibly positioned near internal tissues and used to develop high-resolution images in highly invasive situations. The disclosed device can be developed in kit form as integrate...
Source: NIH OTT Licensing Opportunities - September 26, 2014 Category: Research Authors: admin Source Type: research

Carbon monoxide: A new player in the redox regulation of connexin hemichannels
Abstract Carbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concentration and activating some kinases, including PKG. The other mechanism of action involves induction of protein carbonylation. CO is known to directly and indirectly modulate the function of ion channels at the plasma membrane, which in turn have important repercussions in the cellular behavior. One gr...
Source: IUBMB Life - May 1, 2015 Category: Research Authors: Mauricio A. Retamal, Carmen G. León‐Paravic, Marcelo Ezquer, Fernando Ezquer, Rodrigo Del Rio, Amaury Pupo, Agustín D. Martínez, Carlos González Tags: Critical Review Source Type: research

Microfabricated Particles Useful as MRI Contrast Agents
MRI contrast agents are versatile yet lack the sensitivity and multiplexing capabilities of optical agents. Available for licensing is an invention pertaining to microfabricated structures that can be used as MRI contrast agents with enhanced functionality or as micro-RFID (radio-frequency identification) tags. The microstructures can be engineered to appear as different effective colors when resolved using MRI as opposed to strictly grey-scale contrast of existing MRI agents. In this way they can be thought as radio-frequency analogs to quantum dots. A set of agents could be produced that would enable in vivo labeling and...
Source: NIH OTT Licensing Opportunities - September 1, 2008 Category: Research Authors: admin Source Type: research

Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Authors: Isgrò MA, Bottoni P, Scatena R Abstract Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells. As a result of the findings of NSE in specific...
Source: Advances in Experimental Medicine and Biology - November 6, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Cell death induced by endoplasmic reticulum stress
This article is protected by copyright. All rights reserved.
Source: FEBS Journal - November 20, 2015 Category: Research Authors: Raffaella Iurlaro, Cristina Muñoz Pinedo Tags: Minireview Source Type: research

Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging
; Mickael Tanter Non-invasive imaging deep into organs at microscopic scales remains an open quest in biomedical imaging. Although optical microscopy is still limited to surface imaging owing to optical wave diffusion and fast decorrelation in tissue, revolutionary approaches such as fluorescence photo-activated localization microscopy led to a striking increase in resolution by more than an order of magnitude in the last decade. In contrast with optics, ultrasonic waves propagate deep into organs without losing their coherence and are much less affected by in vivo decorrelation processes. However, their resolution is...
Source: Nature - November 25, 2015 Category: Research Authors: Claudia ErricoJuliette PierreSophie PezetYann DesaillyZsolt LenkeiOlivier CoutureMickael Tanter Tags: Letter Source Type: research

Thalidomide Analogs that Inhibit Inflammation and Angiogenesis
Thalidomide and its close analogs (lenalidomide and pomalidomide) are widely used to treat a variety of diseases, such as multiple myeloma and other cancers as well as the symptoms of several inflammatory disorders. However, thalidomide is known for its teratogenic adverse effects when first clinically introduced in the 1950s, and is associated with drowsiness and peripheral neuropathy. Hence, there is intense interest to synthesize, identify and develop safer analogs.Researchers at the National Institute on Aging’s Drug Design and Development Section synthesized novel thalidomide analogs that demonstrate clinical potent...
Source: NIH OTT Licensing Opportunities - December 23, 2015 Category: Research Authors: admin Source Type: research

Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging.
Authors: Epel B, Redler G, Tormyshev V, Halpern HJ Abstract Electron paramagnetic resonance imaging (EPRI) has been used to noninvasively provide 3D images of absolute oxygen concentration (pO2) in small animals. These oxygen images are well resolved both spatially (~1 mm) and in pO2 (1-3 mmHg). EPRI preclinical images of pO2 have demonstrated extremely promising results for various applications investigating oxygen related physiologic and biologic processes as well as the dependence of various disease states on pO2, such as the role of hypoxia in cancer.Recent developments have been made that help to progress EP...
Source: Advances in Experimental Medicine and Biology - January 21, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

PERSPECTIVES The Economic Promise of Delayed Aging
Biomedicine has made enormous progress in the last half century in treating common diseases. However, we are becoming victims of our own success. Causes of death strongly associated with biological aging, such as heart disease, cancer, Alzheimer’s disease, and stroke-cluster within individuals as they grow older. These conditions increase frailty and limit the benefits of continued, disease-specific improvements. Here, we show that a "delayed-aging" scenario, modeled on the biological benefits observed in the most promising animal models, could solve this problem of competing risks. The economic value of delayed agin...
Source: Cold Spring Harbor perspectives in medicine - February 1, 2016 Category: Research Authors: Goldman, D. Tags: Aging PERSPECTIVES Source Type: research

A new measure for in vivo thrombin activity in comparison with in vitro thrombin generation potential in patients with hyper- and hypocoagulability
Abstract The thrombin generation potential is an in vitro measure for the capacity of an individual to generate thrombin and recognized as a reflection of a hypo- or hypercoagulable status. Measurement of the in vivo thrombin activity, however, may be of clinical significance. We evaluated a new assay for in vivo thrombin activity and compared it to the in vitro thrombin generation potential in patients with hemophilia A (N = 15), oral anticoagulation for atrial fibrillation (AF) (N = 20), subjects with active cancer (N = 21), and healthy volunteers (N = 10). Thrombin activity was measured with a comme...
Source: Clinical and Experimental Medicine - April 18, 2016 Category: Research Source Type: research

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