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Total 245 results found since Jan 2013.

Risk of Cancer Following an Ischemic Stroke in the Canadian Longitudinal Study on Aging
Can J Neurol Sci. 2021 Mar 26:1-16. doi: 10.1017/cjn.2021.55. Online ahead of print.NO ABSTRACTPMID:33766161 | DOI:10.1017/cjn.2021.55
Source: The Canadian Journal of Neurological Sciences - March 26, 2021 Category: Neurology Authors: Bastien Rioux Laura C Gioia Mark R Keezer Source Type: research

Prevalence and Predictors of Multivitamin Supplement Use After Stroke in Ghana
Multivitamin supplementation is widely practiced in high-income countries due to a popular belief of its health promotion and disease prevention benefits. Evidence for their purported efficacy has been mixed. Regarding the efficacy of multivitamins on prevention of cardiovascular disease, cancer, or all-cause mortality, some studies have shown no effect,1 –4 harmful effects,5,6 and beneficial effects.7,8 Three prospective studies have evaluated the effect of multivitamin use on stroke prevention with two showing negative outcomes3,5 and the third among 72,000 Japanese showing frequent use of multivitamins was associated ...
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2021 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele Source Type: research

The Effect of Histone Deacetylase Inhibitors Panobinostat or Entinostat on Motor Recovery in Mice After Ischemic Stroke
AbstractUsing rigorous and clinically relevant experimental design and analysis standards, in this study, we investigated the potential of histone deacetylase (HDAC) inhibitors panobinostat and entinostat to enhance recovery of motor function after photothrombotic stroke in male mice. Panobinostat, a pan-HDAC inhibitor, is a FDA-approved drug for certain cancers, whereas entinostat is a class-I HDAC inhibitor in late stage of clinical investigation. The drugs were administered every other day (panobinostat —3 or 10 mg/kg; entinostat—1.7 or 5 mg/kg) starting from day 5 to 15 after stroke. To imitate the current standa...
Source: NeuroMolecular Medicine - February 15, 2021 Category: Neurology Source Type: research

Effectiveness of mechanical thrombectomy in cancer-related stroke and associated factors with unfavorable outcome
This study aims to investigate the clinical and radiological outcomes of MT in CRS patients. We also explore...
Source: BMC Neurology - February 6, 2021 Category: Neurology Authors: Eung-Joon Lee, Jeonghoon Bae, Hae-Bong Jeong, Eun Ji Lee, Han-Yeong Jeong and Byung-Woo Yoon Tags: Research article Source Type: research

Effects of Neck Radiation on Result of Doppler Sonography of Carotid Arteries in Head and Neck Cancer Patients
The aim of this study was to assess the effects of neck radiation on the results of Doppler sonography of carotid arteries in head and neck cancer patients.
Source: Journal of Stroke and Cerebrovascular Diseases - January 15, 2021 Category: Neurology Authors: Ali Akhavan, Maryam Farghadani, Hamid Emami, Zahra Naderi Beni, Afsaneh Naderi Beni Source Type: research

Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury.
We examined the effect of maraviroc, a CCR5 antagonist used in HIV patients as a viral entry inhibitor, and of plerixafor (AMD3100), a CXCR4 antagonist used in cancer patients as an immune-modulator, on mice subjected to closed head injury (CHI). Mice were treated with maraviroc or plerixafor after CHI for the following 4 or 5 days, respectively. Neurobehavior was assessed according to the Neurological Severity Score; cognitive tests were performed by using the Y-maze, Barnes maze and the novel object recognition test; anxiety was evaluated with the open field test. The mice were sacrificed and brain tissues were collect...
Source: Experimental Neurology - January 13, 2021 Category: Neurology Authors: Friedman-Levi Y, Liraz-Zaltsman S, Shemesh C, Rosenblatt K, Kesner EL, Gincberg G, Carmichael ST, Silva AJ, Shohami E Tags: Exp Neurol Source Type: research

Lynch syndrome-associated repeated stroke with MLH1 frame-shift mutation
We describe the case of a 34-year-old female patient with 50  days of sudden dizziness and left limb weakness, whose head CT scan showed large infarction in the right frontal temporal parietal lobe and basal ganglia area. Imaging examinations and pathological biopsy indicated high-grade serous carcinoma (HGSC) IIIA1 of the right ovary. In addition, a novel f rame-shift mutation in the MLH1 gene (c.1621dupG, p.A541Gfs*16) was found in the genetic panel sequence. It may render declining of MLH1 protein and also associate with the patient’s progressive clinical manifestations of multiple systems. Therefore, the timely use ...
Source: Neurological Sciences - January 12, 2021 Category: Neurology Source Type: research

Lacunar stroke as a very late complication of radiotherapy: value of nuclear medicine techniques.
CONCLUSIONS: The reappearance of neurological symptoms years after radiotherapy of a brain neoplasm poses a diagnostic dilemma. Current diagnostic techniques are very accurate but present false positives. The various nuclear medicine techniques, in particular PET-CT 11C-methionine, are a diagnostic aid. With the presentation of this case we intend to draw attention to one of the late complications of radiation therapy and the various differential diagnoses. Diagnostic and therapeutic advances have increased the life expectancy of cancer patients, so these late complications are expected to be more frequent. PMID: 3331...
Source: Revista de Neurologia - December 16, 2020 Category: Neurology Authors: Ortega-Valín F, Jiménez-Bonilla JF, García-Hernández A, Rodríguez-Rodriguez E, Sánchez-Salmón E Tags: Rev Neurol Source Type: research

Association of admission leukocyte count with clinical outcomes in acute ischemic stroke patients undergoing intravenous thrombolysis with recombinant tissue plasminogen activator.
CONCLUSION: Lower admission leukocyte count independently predicts good and excellent outcomes at 3 months in AIS patients undergoing rt-PA treatment. PMID: 33243121 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - November 25, 2020 Category: Neurology Authors: Chen J, Zhang FL, Lv S, Jin H, Luo Y, Qu Y, Guo ZN, Yang Y Tags: Curr Neurovasc Res Source Type: research

Diet and Lifestyle as Risk Factors for Carotid Artery Disease: A Prospective Cohort Study
Conclusions: In conclusion, the present study found a trend toward a protective effect of higher intake of vegetables and fruit against incident CAD. More prospective studies investigating the association between diet and CAD and stroke are needed in order to give firm recommendations.Cerebrovasc Dis
Source: Cerebrovascular Diseases - October 19, 2020 Category: Neurology Source Type: research

Pathophysiology, Mechanism, and Outcome of Ischemic Stroke in Cancer Patients
The purpose of this study is to assess the risk factors, biomarkers of stroke, mechanism, and outcomes of cerebral infarction among cancerous diseases.
Source: Journal of Stroke and Cerebrovascular Diseases - September 17, 2020 Category: Neurology Authors: Mohamed Abdelsalam, Mohammad Abu-Hegazy, Hend Ahmed El-Hadaad, Hanan Wahba, Hossam Egila, Ahmed Esmael Source Type: research