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Cancer: Gastric (Stomach) Cancer

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Total 1410 results found since Jan 2013.

Tumor-associated macrophages induce invasion and poor prognosis in human gastric cancer in a cyclooxygenase-2/MMP9-dependent manner.
Authors: Xu J, Yu Y, He X, Niu N, Li X, Zhang R, Hu J, Ma J, Yu X, Sun Y, Ni H, Wang F Abstract Cyclooxygenase-2 (COX2) and tumor-associated macrophages (TAMs) are associated with invasion, angiogenesis, and poor prognosis in many human cancers. However, the role of TAMs in human gastric cancer (GC) remains elusive. In the present study, we first measured COX2 expression and TAM infiltration in human GC tissues using double immunohistochemical staining. Then, we indirectly cocultured M2-polarized macrophages derived from human THP-1 cells with GC cells as an in vitro model. Transwell assays, siRNA transfection, tre...
Source: American Journal of Translational Research - October 23, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Inhibition of Splicing Factor 3b Subunit 1 (SF3B1) Reduced Cell Proliferation, Induced Apoptosis and Resulted in Cell Cycle Arrest by Regulating Homeobox A10 (HOXA10) Splicing in AGS and MKN28 Human Gastric Cancer Cells.
CONCLUSIONS In AGS and MKN28 human gastric cancer cells in vitro, inhibition of SF3B1 reduced cell proliferation, induced apoptosis, and resulted in cell cycle arrest by regulating HOXA10 splicing. PMID: 31927557 [PubMed - in process]
Source: Medical Science Monitor - January 14, 2020 Category: Research Tags: Med Sci Monit Source Type: research

lncRNA SNHG1 suppresses gastric cancer cell proliferation and promotes apoptosis via Notch1 pathway.
CONCLUSIONS: LncRNA SNHG1 can depend on the Notch1 pathway to suppress the proliferation of gastric cancer cells and promote their apoptosis. PMID: 32277646 [PubMed - as supplied by publisher]
Source: Journal of B.U.ON. - April 13, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Value of long non-coding RNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy.
CONCLUSION: Rpph1 is highly expressed in esophageal cancer. Silencing Rpph1 expression can promote cell apoptosis, inhibit cell proliferation and migration, and increase radio-sensitivity. PMID: 32351293 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 20, 2020 Category: Gastroenterology Authors: Li ZY, Li HF, Zhang YY, Zhang XL, Wang B, Liu JT Tags: World J Gastroenterol Source Type: research

Expression of MACC1 protein in gastric cancer and its effect on proliferation and invasion of gastric cancer cells.
CONCLUSION: MACC1 was highly expressed in gastric cancer tissues. The expression of MACC1 was related to the differentiation degree, infiltration depth, lymph node metastasis and staging of gastric cancer. Down-regulation of MACC1 could inhibit the proliferation and invasion of gastric cancer cells. This study provided a certain biological basis for early clinical prediction, diagnosis and treatment of gastric cancer. PMID: 32415936 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Biology - May 18, 2020 Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Keratin 18 (KRT18) induces proliferation, migration, and invasion in gastric cancer via the MAPK signaling pathway.
CONCLUSIONS: KRT18 plays a cancer-promoting role and might be a potential therapeutic target in the treatment of GC. PMID: 32860257 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - August 27, 2020 Category: Drugs & Pharmacology Authors: Wang PB, Chen Y, Ding GR, Du HW, Fan HY Tags: Clin Exp Pharmacol Physiol Source Type: research

Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling.
Authors: Du J, Fu L, Hao J, Lin X, Dong Q Abstract Dysregulation of Rab11a has been implicated in the progression of several cancers. However, there have been no such studies for human gastric cancers. In the current study, we examined Rab11a protein expression and found it was upregulated in 49 of 108 gastric cancer tissues and correlated with local invasion, nodal metastasis, and advanced stage. Rab11a protein was higher in gastric cancer cell lines than normal gastric cell line. We transfected Rab11a plasmid and siRNA in both MGC803 and AGS cell lines. Rab11a overexpression increased the cell growth rate, colony...
Source: Journal of Oncology - November 14, 2020 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Blockage of ETS homologous factor inhibits the proliferation and invasion of gastric cancer cells through the c-Met pathway.
CONCLUSION: These results suggest that EHF plays a key role in cell proliferation, invasion, apoptosis, the cell cycle and EMT via the c-Met pathway. Therefore, EHF may serve as an antineoplastic target for the diagnosis and treatment of GC. PMID: 33384550 [PubMed - in process]
Source: World Journal of Gastroenterology - December 21, 2020 Category: Gastroenterology Authors: Gu ML, Zhou XX, Ren MT, Shi KD, Yu MS, Jiao WR, Wang YM, Zhong WX, Ji F Tags: World J Gastroenterol Source Type: research

Blockage of ETS homologous factor inhibits the proliferation and invasion of gastric cancer cells through the c-Met pathway
CONCLUSION: These results suggest that EHF plays a key role in cell proliferation, invasion, apoptosis, the cell cycle and EMT via the c-Met pathway. Therefore, EHF may serve as an antineoplastic target for the diagnosis and treatment of GC.PMID:33384550 | PMC:PMC7754554 | DOI:10.3748/wjg.v26.i47.7497
Source: World Journal of Gastroenterology - January 1, 2021 Category: Gastroenterology Authors: Meng-Li Gu Xin-Xin Zhou Meng-Ting Ren Ke-Da Shi Mo-Sang Yu Wen-Rui Jiao Ya-Mei Wang Wei-Xiang Zhong Feng Ji Source Type: research

IL ‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway
In conclusion, it was found that ST2 was highly expressed in GC tissues. IL‑33/ST2 promoted the malignant progression of GC cells by inducing the activation of ERK1/2, JNK and p38.PMID:33760194 | DOI:10.3892/mmr.2021.12000
Source: Molecular Medicine Reports - March 24, 2021 Category: Molecular Biology Authors: Ning Huang Xing Cui Wen Li Chunlai Zhang Liqing Liu Jinxing Li Source Type: research

GSE163164 Gene expression profiling of AGS Gastric Cancer cells upon YY1 knock down
Contributors : B DIVYA ; G KUMARESANSeries Type : Expression profiling by arrayOrganism : Homo sapiensYin Yang 1 (YY1) is a ubiquitous transcription factor belonging to the GLI-Kruppel class of zinc finger proteins regulating diverse biological processes including cell proliferation, development, DNA damage responses and also involved in carcinogenesis. The protein is involved in repressing and activating a diverse number of promoters.In order to study the role of the transcription factor YY1 in gastric cancer, transcriptome wide gene expression analysis was performed upon silencing the YY1 gene in gastric cancer cell line...
Source: GEO: Gene Expression Omnibus - March 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

IL ‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway
In conclusion, it was found that ST2 was highly expressed in GC tissues. IL‑33/ST2 promoted the malignant progression of GC cells by inducing the activation of ERK1/2, JNK and p38.PMID:33760194 | PMC:PMC7985998 | DOI:10.3892/mmr.2021.12000
Source: Molecular Medicine Reports - March 24, 2021 Category: Molecular Biology Authors: Ning Huang Xing Cui Wen Li Chunlai Zhang Liqing Liu Jinxing Li Source Type: research