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Total 164 results found since Jan 2013.

Hemostasis and Bone Regeneration Using Chitosan/Gelatin-BCP Bi-layer Composite Material
The aim of the study was to determine the hemostatic activity of a composite bi-layered topical hemostat composed of electrospun gelatin loaded with bi-phasic calcium phosphate and chitosan layer and its effect on bone formation. Morphology of the composite hemostat and its individual components were observed using scanning electron microscopy. In vitro biocompatibility of the topical hemostat tested using preosteoblasts cells (MC3t3-E1) showed no adverse toxicity. Confocal microscopy of seeded cells showed good cell adhesion while 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated 15% incre...
Source: ASAIO Journal - July 30, 2019 Category: Medical Devices Tags: Tissue Engineering/ Biomaterials Source Type: research

Application techniques of a novel hemostat in cardiac operations: HEMOBLAST
ConclusionHB is a novel powder ‐based multiple component hemostatic agent that promotes focal or large area hemostasis. We have presented the techniques of use that are important to the successful application of HB to facilitate hemostasis.
Source: Journal of Cardiac Surgery - July 25, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Brian A. Bruckner, Uy Ngo, Mahesh Ramchandani, Erik Suarez, Samir Awad, Michael Reardon Tags: SURGICAL TECHNIQUE Source Type: research

Contralateral C7 transfer combined with acellular nerve allografts seeded with differentiated adipose stem cells for repairing upper brachial plexus injury in rats.
This study was approved by the Animal Ethics Committee of the First Affiliated Hospital of Sun Yat-sen University of China (approval No. 2016-150) in June 2016. PMID: 31290451 [PubMed]
Source: Cell Research - July 12, 2019 Category: Cytology Authors: Yang JT, Fang JT, Li L, Chen G, Qin BG, Gu LQ Tags: Neural Regen Res Source Type: research

In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis
AbstractFibrin glue has been widely used as a surgical sealing and hemostatic agent. Its application is restricted due to poor tissue adhesion and low mechanical strength. To develop better tissue sealant and hemostatic agent, this study prepared the injectable hydrogels by chemically cross ‐linking gelatin (G) with or without hyaluronic acid (HA) in situ at a mild condition. The rheological analysis, Fourier transform infrared spectroscopy, swelling, proteolytic degradation, biocompatibility, tissue sealing, and hemostatic ability of the hydrogels were investigated. It was found tha t the chemical cross‐linking rapidl...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 20, 2019 Category: Materials Science Authors: Jing ‐Wan Luo, Chang Liu, Jing‐Heng Wu, Dan‐Hui Zhao, Long‐Xiang Lin, Hai‐Ming Fan, Yu‐Long Sun Tags: ORIGINAL RESEARCH REPORT Source Type: research

Efficacy of New Polylactic Acid Nonwoven Fabric as a Hemostatic Agent in a Rat Liver Resection Model.
DISCUSSION: This new PLAF showed superior outcomes thanks to its unique characteristic of forming beaded nanofibers, and it has the potential to be an efficient hemostat in minimally invasive surgery in the human body. PMID: 30895890 [PubMed - as supplied by publisher]
Source: Surgical Innovation - March 20, 2019 Category: Surgery Authors: Wakabayashi T, Yagi H, Tajima K, Kuroda K, Shinoda M, Kitago M, Abe Y, Oshima G, Hirukawa K, Itano O, Kitagawa Y Tags: Surg Innov Source Type: research

Lymphostasis and Hemostasis in Body-Contouring Surgery Using a Polysaccharide Based Hemostat (4DryField PH)
Conclusions: This is the first prospective, monocentric, randomized study on 4DF in body-contouring surgery. The use of 4DF did not lead to a better postoperative outcome regarding hemostasis and lymphostasis. Potential benefits need further evaluation in high-volume studies.
Source: Plastic and Reconstructive Surgery Global Open - March 1, 2019 Category: Cosmetic Surgery Tags: Original Article Source Type: research

Effects of Ankaferd Hemostat on Helicobacter pylori strains and antibiotic resistance
Conclusion: Our present study indicated, for the first time, that ABS could act against H. pylori. ABS is clinically used for the management of GI bleeding due to benign and malignant GI lesions. Thus, the possible anti-H. pylori effect of ABS shall expand the therapeutic spectrum of the drug in GI lesions in relation to H. pylori infection such as peptic ulser disease (PUD) and lymphoid tissue (MALT) lymphomagenesis. PMID: 30761849 [PubMed - in process]
Source: Turkish Journal of Medical Sciences - February 16, 2019 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study
Conclusion: ABS has antierythroid aggregation effect. ABS inhibits pathological aggregation of red blood cells. Antithrombotic clinical effects of ABS may be ascribed to the antierythroid aggregan actions of the drug. PMID: 30761848 [PubMed - in process]
Source: Turkish Journal of Medical Sciences - February 16, 2019 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Comparison between LigaSure ™ and Harmonic® in Laparoscopic Sleeve Gastrectomy: A Single-Center Experience on 422 Patients.
Conclusion: Harmonic® and LigaSure™ are both useful tools in bariatric surgery, and these two advanced power devices are user-friendly and can facilitate surgeon work; from this point of view, the choice of the energy device should be based on the preference of the surgeon and on the hospital costs policy and availability. PMID: 30719344 [PubMed - in process]
Source: Journal of Obesity - February 7, 2019 Category: Eating Disorders & Weight Management Tags: J Obes Source Type: research

Advanced Medical Solutions Group plc: Acquisition of Sealantis
Winsford, UK, 31 January 2019: Advanced Medical Solutions Group plc (AIM: AMS), the surgical and advanced wound care specialist company, today announces it has acquired Sealantis Limited ( “Sealantis”), a developer of an alginate-based tissue adhesive technology platform, for $US 25m (approximately £19m) in cash with royalties due until December 2027 on sales of any of its products that are currently in development.Overview of SealantisSealantis is an Israeli-based medical device company with a patent-protected alga-mimetic sealants technology platform with a wide range of potential surgical indications under developm...
Source: Medical Hemostat - February 1, 2019 Category: Medical Devices Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

A modified endovascular treatment protocol for iatrogenic internal carotid artery injuries following endoscopic endonasal surgery.
CONCLUSIONSThe endovascular treatment protocol used in this study for ICA injuries during EES was helpful in the management of this rare complication. Willis stent placement improved the preservation rate of injured ICA during EES. It would be highly advantageous to manage this complication in a hybrid OR or by a mobile C-arm to get a clear intraoperative angiogram. PMID: 30684942 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - January 25, 2019 Category: Neurosurgery Authors: Zhang Y, Tian Z, Li C, Liu J, Zhang Y, Yang X, Zhang Y Tags: J Neurosurg Source Type: research

Enhancement of Hemostatic Property of Plant Derived Oxidized Nanocellulose-Silk Fibroin Based Scaffolds by Thrombin Loading
Publication date: Available online 19 December 2018Source: Carbohydrate PolymersAuthor(s): Anha Afrin Shefa, Mirana Taz, Sun Young Lee, Byong-Taek LeeAbstractTo combat post-surgical and traumatic bleeding conditions effective hemostasis is of great importance. The study was designed to investigate the effect of thrombin (Th) loading on hemostatic performance of TEMPO-oxidized cellulose nanofiber (TOCN)-silk fibroin (SF) scaffolds. Addition of SF with TOCN significantly (***P < 0.001) increased blood absorption capacity and improved biocompatibility of TOCN. Thrombin loading potentiated platelet activation and hemostati...
Source: Carbohydrate Polymers - December 21, 2018 Category: Biomedical Science Source Type: research

Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding.
Abstract Lethal bleeding due to street accidents, natural calamities, orthopedic/dental surgeries, organ transplantation and household injuries, is the leading cause of morbidity and mortality. In the current study, zinc oxide (ZnO) was incorporated in TEMPO-oxidized cellulose nanofiber (TOCN) and polyethylene glycol (PEG) polymer system for hemorrhage control by freeze drying method. SEM and XRD data showed the presence of ZnO in the porous structure. FT-IR analysis showed that, successful conjugation occurs among the TOCN and PEG. The results revealed that, the incorporation of ZnO and higher concentrations of P...
Source: International Journal of Biological Macromolecules - December 8, 2018 Category: Biochemistry Authors: Shefa AA, Taz M, Hossain M, Kim YS, Lee SY, Lee BT Tags: Int J Biol Macromol Source Type: research

Baxter touts Hemopatch, Floseal study results
Baxter (NYSE:BAX) today presented results from studies of its Hemopatch and Floseal products, touting reductions in costs and hospital stays in both trials. Results from studies of the devices were presented this week at the International Society for Pharmacoeconomics and Outcomes Research Europe 2018 meeting, the Chicago-based company said. In a retrospective observational analysis exploring pancreaticoduodenectomies which used the company’s Hemopatch hemostatic-sealant, investigators in Spain found that the device “might be an effective and cost-beneficial additional treatment compared to the Standard of Car...
Source: Mass Device - November 13, 2018 Category: Medical Devices Authors: Fink Densford Tags: Blood Management Clinical Trials Surgical Baxter Source Type: news

BARDA adds $26m to Stratatech ’ s StrataGraft development deal
Mallinckrodt‘s (NYSE: MNK) Stratatech has won an additional $26 million in Project BioShield funding from the the U.S. Biomedical Advanced Research and Development Authority to support pediatric studies of its StrataGraft engineered skin tissue. The funding will support continued development of the StrataGraft as a potential medical countermeasure for large-scale burn incidents, U.K.-based Mallinckrodt said. BARDA previously supplied funding to Stratatech during its Phase 3 trial of the Stratagraft in adults, which explored the safety and efficacy of the device in promoting autologous skin regeneration of complex ...
Source: Mass Device - October 17, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Featured Regenerative Medicine Wound Care Mallinckrodt Stratatech Corp. Source Type: news