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Therapy: Corticosteroid Therapy

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Total 2470 results found since Jan 2013.

Investigational medications in 9,638 hospitalized patients with severe COVID-19: lessons from the "fail-and-learn" strategy during the first two waves of the pandemic in 2020
CONCLUSION: This retrospective multicenter observational cohort study on 9,638 hospitalized patients with severe COVID-19 during revealed that the necessity for invasive ventilation had the highest odds of mortality, beyond the variable effects observed by administration of the prevalent EUA-approved investigational drugs during the first two surges of the early 2020 pandemic in the United States.PMID:37041643 | PMC:PMC10088131 | DOI:10.1186/s13037-023-00358-9
Source: Patient Safety in Surgery - April 11, 2023 Category: Surgery Authors: Adam C Delgado Brendon Cornett Ye Ji Choi Christina Colosimo Vincent P Stahel Oliwier Dziadkowiec Philip F Stahel Source Type: research

Impact of the COVID-19 pandemic on inflammatory bowel disease care in Taiwan: A multicenter study
CONCLUSIONS: The medical behavior of IBD patients was influenced by the COVID-19 pandemic, and their anxiety could be mitigated after education.PMID:37019722 | DOI:10.1016/j.jfma.2023.03.017
Source: J Formos Med Assoc - April 5, 2023 Category: General Medicine Authors: Yen-Ling Peng Chung-Hsin Chang Shu-Chen Wei Tien-Yu Huang Wei-Chen Tai Wen-Hung Hsu Deng-Chyang Wu Hsu-Heng Yen Chi-Ming Tai Chen-Wang Chang Wei-Chen Lin Horng-Yuan Wang Chun-Chi Lin Chia-Jung Kuo Cheng-Tang Chiu Ching-Pin Lin Hsi-Chang Lee Jia-Feng Wu Ch Source Type: research

A comprehensive review of therapeutic options for COVID-19
In this study, by investigating some available antimicrobial medicines that may diminish COVID-19 infection, we are trying to introduce a general protocol for controlling this disease.
Source: Ethiopian Journal of Health Development - April 5, 2023 Category: African Health Authors: Mohammad Darvishi, Shahriar Sepahvand, Mohammad Reza Nazer, Hamze Shahali, Mahboobeh Madani, Hassan Sepahvand, Vajihe Karbasizade Source Type: research

The association between inhaled corticosteroid and the risks of SARS-COV-2 infection: A systematic review and meta-analysis
CONCLUSIONS: The use of ICS, either monotherapy or in combination with bronchodilators, does not have impact on the risk of SARS-COV-2 infection.PMID:37003028 | DOI:10.1016/j.jiph.2023.03.019
Source: Cancer Control - April 1, 2023 Category: Cancer & Oncology Authors: Chao-Hsien Chen Ching-Yi Chen Chih-Cheng Lai Ya-Hui Wang Kuang-Hung Chen Cheng-Yi Wang Yu-Feng Wei Pin-Kuei Fu Source Type: research

Respiratory recovery trajectories after severe-to-critical COVID-19: a 1-year prospective multicentre study
Conclusions Although pulmonary function and radiological abnormalities improved up to 1 year post-acute COVID-19, high percentages of severe-to-critical disease survivors, including a notable proportion of those managed with standard oxygen, had significant lung sequelae and residual symptoms justifying prolonged follow-up.
Source: European Respiratory Journal - April 1, 2023 Category: Respiratory Medicine Authors: Schlemmer, F., Valentin, S., Boyer, L., Guillaumot, A., Chabot, F., Dupin, C., Le Guen, P., Lorillon, G., Bergeron, A., Basille, D., Delomez, J., Andrejak, C., Bonnefoy, V., Goussault, H., Assie, J.-B., Choinier, P., Ruppert, A.-M., Cadranel, J., Mennitti Tags: Respiratory infections and tuberculosis Original Articles: COVID-19 Source Type: research

Bilateral Longitudinally Extensive Optic Perineuritis Post ‐COVID‐19 Presenting as “Idiopathic” Intracranial Hypertension: A Case Report
ConclusionThere is a growing association between demyelinating disorders and COVID-19 and COVID-19 vaccination, it is essential to recognize CSF abnormalities that are incompatible with a diagnosis of IIH, such as increased protein in our case, and may lead to an incorrect diagnosis.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Neuroimmunology - March 25, 2023 Category: Neurology Authors: Mohammad Aladawi, Daniel Crespo, Renfeng Xu, Rana Zabad, Amrita ‐Amanda Vuppala Tags: CASE REPORT Source Type: research

Brain Leukocytes as the Potential Therapeutic Target for Post-COVID-19 Brain Fog
Neurochem Res. 2023 Mar 23. doi: 10.1007/s11064-023-03912-0. Online ahead of print.ABSTRACTAfter recovering from the acute phase of coronavirus disease 2019 (COVID-19), many patients struggle with additional symptoms of long COVID during the chronic phase. Among them, the neuropsychiatric manifestations characterized by a short-term memory loss and inability to concentrate are called "brain fog". Recent studies have revealed the involvement of "chronic neuro-inflammation" in the pathogenesis of brain fog following COVID-19 infection. In the COVID-related brain fog, similarly to neurodegenerative disorders caused by neuro-i...
Source: Neurochemical Research - March 23, 2023 Category: Neuroscience Authors: Itsuro Kazama Source Type: research

Corticosteroids reduce pathologic interferon responses by downregulating STAT1 in patients with high-risk COVID-19
Exp Mol Med. 2023 Mar 20:1-12. doi: 10.1038/s12276-023-00964-8. Online ahead of print.ABSTRACTWe do not yet understand exactly how corticosteroids attenuate hyperinflammatory responses and alleviate high-risk coronavirus disease 2019 (COVID-19). We aimed to reveal the molecular mechanisms of hyperinflammation in COVID-19 and the anti-inflammatory effects of corticosteroids in patients with high-risk COVID-19. We performed single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from three independent COVID-19 cohorts: cohort 1 was used for comparative analysis of high-risk and low-risk COVID-19 (47 PBMC sam...
Source: Molecular Medicine - March 21, 2023 Category: Molecular Biology Authors: Hyun-Woo Jeong Jeong Seok Lee Jae-Hoon Ko Seunghee Hong Sang Taek Oh Seongkyun Choi Kyong Ran Peck Ji Hun Yang Seok Chung Sung-Han Kim Yeon-Sook Kim Eui-Cheol Shin Source Type: research

Optimal time for COVID-19 vaccination in rituximab-treated dermatologic patients
ConclusionsNine months of rituximab-to-vaccination interval maximize the immunological benefits of COVID-19 vaccines while avoiding unnecessary delay in vaccination and rituximab treatment for IMDD patients.
Source: Frontiers in Immunology - March 15, 2023 Category: Allergy & Immunology Source Type: research

Recurrent Acute Disseminated Encephalomyelitis (ADEM) after COVID-19-vaccination and after subsequent COVID-19-infection: A case report (part II)
Acute disseminated encephalomyelitis (ADEM) is an autoimmune disorder of the central nervous system (CNS), which is commonly associated to previous viral infection or immunization. Cases of ADEM with a potential relationship to both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination have been reported. We recently published a rare case of a 65-year-old patient who suffered from a corticosteroid- and immunoglobulin-refractory multiple autoimmune syndrome including ADEM following Pfizer-BioNTech coronavirus disease (COVID)-19 vaccination, and whose symptoms largely resolved after repeated ...
Source: Frontiers in Neurology - March 10, 2023 Category: Neurology Source Type: research

Endogenous Fungal Endophthalmitis following COVID-19 Hospitalization: Evidence from a Year-Long Observational Study
CONCLUSION: Ophthalmologists should maintain a high index of clinical suspicion for EFE in cases with visual symptoms and a history of recent COVID-19 hospitalization and/or systemic corticosteroid use - even without other well-known risk factors.PMID:36890074 | DOI:10.1016/j.jfo.2022.12.002
Source: Journal Francais d Ophtalmologie - March 8, 2023 Category: Opthalmology Authors: S Fekri M Khorshidifar F Esfahanian A Veisi H Nouri S-H Abtahi Source Type: research