Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Do Fats Do in the Body?
It’s common knowledge that too much cholesterol and other fats can lead to disease and that a healthy diet involves watching how much fatty food we eat. However, our bodies need a certain amount of fat to function—and we can’t make it from scratch.
Hepatocytes, like the one shown here, are the most abundant type of cell in the human liver. One important role they play is producing bile, a liquid that aids in digesting fats. Credit: Donna Beer Stolz, University of Pittsburgh.
Triglycerides, cholesterol, and other essential fatty acids—the fats our bodies can’t make on their own—store energy, ins...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 24, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Common questions Source Type: blogs
The Germline Impacts Life Span
One evolutionary perspective on life is that the individuals making up a species are secondary concerns, mere wrappers for the all-important germline cells. Evolution optimizes for success in propagation of the germline lineage, not the success of the individual. With that in mind, one might expect to find that the germline can influence the body. That influence doesn't have to be a net positive for the individual, as noted here. The individual is disposable, and health only matters insofar as it enhances reproductive fitness in the eternal, ever-shifting arms race that takes place over evolutionary time.
Classica...
Source: Fight Aging! - January 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Genetic Associations with Longevity are Stronger in Women
In this study, we discovered that genetic associations with longevity are on average stronger in females than in males through bio-demographic analyses of genome-wide association studies (GWAS) dataset of 2178 centenarians and 2299 middle-age controls of Chinese Longitudinal Healthy Longevity Study (CLHLS). This discovery is replicated across North and South regions of China, and is further confirmed by North-South discovery/replication analyses of different and independent datasets of Chinese healthy aging candidate genes with CLHLS participants who are not in CLHLS GWAS, including 2972 centenarians and 1992 middle-age co...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Role for the Gut Microbiome in the Aging of the Ovaries
As is the case for the thymus, aging and loss of function in the ovaries is interesting for (a) occurring at an accelerated pace relative to the rest of the body, and (b) producing meaningful downstream consequences in later life. What causes this comparatively early loss of function? Here, researchers look at changes in the balance of microbial populations in the gut microbiome as a contributing factor. The gut microbiome also shows age-related changes comparatively early in adult life, in which pro-inflammatory microbes expand in number whilst those producing beneficial metabolites decline in number.
Altered com...
Source: Fight Aging! - January 16, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sirtuin 2 Overexpression Fails to Extend Life in Mice
One long-lasting result of the hype engineered over sirtuin 1 overexpression as a possible avenue to modestly slow aging is a continued focus on other sirtuins in the context of aging. Sirtuin 1 overexpression turned out to be entirely unimpressive, a dead end. Sirtuin 6, however, is more interesting, and overexpression in mice does modestly extend life span, possibly by improving DNA repair efficiency. It may also be the case that sirtuin 3 overexpression can improve mitochondrial function to a great enough degree to also be interesting.
On the whole, however, this sort of approach to manipulating metabolism has y...
Source: Fight Aging! - January 4, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Does Tubal Reversal Work?
Does tubal reversal work? Reversal can be very successful when you see a surgeon who has the experience to help you realize your dreams!
The post Does Tubal Reversal Work? appeared first on A Personal Choice. (Source: Tubal Reversal Blog)
Source: Tubal Reversal Blog - December 19, 2023 Category: Reproduction Medicine Authors: Dr. Monteith Tags: Dr. Monteith pregnancy after tubal reversal reversing tied tubes tubal ligation reversal Tubal Reversal Procedure tubal reversal surgery tubal surgery untie tubes why tubal reversal a tubal reversal can does tubal reversal work get a Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Looking for Evidence of Antagonistic Pleiotropy in Human Data
The dominant view of the evolution of aging is that it emerges from what is known as antagonistic pleiotropy, a term used to describe a mechanism that is initially helpful but later harmful. Mutations that help early life reproductive fitness will be selected even if they cause later harm, as a greater chance of earlier reproduction tends to win out over a greater chance of sustained reproduction over time. Natural selection thus tends to produce biological systems that invest little in long-term maintenance and sustainability. Aging is the result.
In 1957, evolutionary biologist George Williams proposed that gene...
Source: Fight Aging! - December 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
2024 New Year ’ s Special Tubal Reversal Surgery Deal!
A Personal Choice is offering a one time only, very special 2024 tubal reversal surgery discount up to $500 and paid two nights hotel stay!
The post 2024 New Year’s Special Tubal Reversal Surgery Deal! appeared first on A Personal Choice. (Source: Tubal Reversal Blog)
Source: Tubal Reversal Blog - December 3, 2023 Category: Reproduction Medicine Authors: Dr. Monteith Tags: tubal reversal cost of essure reversal cost of reversal surgery cost of vasectomy reversal hotel tubal reversal discount tubal reversal surgery Source Type: blogs
Optimizing Patient and Physician Experience Improves Access for Axia Women ’ s Health
Axia Women’s Health is on a mission to provide top-tier care for women. To achieve their goal, they are proactively streamlining internal processes and optimizing their EHR to reduce physician workload. The result is more personalized encounters and improved patient experiences. Here is how they did it.
Women’s Healthcare
With 450 providers spread across five states on the East Coast and in the Midwest, Axia Women’s Health (AxiaWH) are at the forefront of changing the landscape of women’s healthcare. AxiaWH offers OBGYN, fertility, and other ancillary services such as mammograms to patients.
According to th...
Source: EMR and HIPAA - November 28, 2023 Category: Information Technology Authors: Colin Hung Tags: Ambulatory Communication and Patient Experience EMR-EHR Health IT Company Healthcare IT #ptexp Axia Women's Health AxiaWH Digital Front Door eClinicalWorks eCW eCWNC23 Eduard de Vries Healthcare IT Video Interviews Healthcare S Source Type: blogs
Tubal Reversal Surgery, How One Woman Won A Free Tubal Reversal Procedure!
A personal story of how one woman won a free tubal reversal surgery procedure from Dr Monteith of A Personal Choice in Raleigh NC.
The post Tubal Reversal Surgery, How One Woman Won A Free Tubal Reversal Procedure! appeared first on A Personal Choice. (Source: Tubal Reversal Blog)
Source: Tubal Reversal Blog - November 26, 2023 Category: Reproduction Medicine Authors: Dr. Monteith Tags: free tubal reversal surgery free contest free ligation reversal surgery free tubal reversal contest getting tubes untied for free Tubal Reversal Procedure untie tubes Source Type: blogs
Updates for Our Medicine and the Arts Feature
Medicine and the Arts (MATA) is Academic Medicine’s longest-running feature. Since 1991, MATA authors have explored the relationship between art and the teaching, learning, and practice of medicine. MATA has long served a unique role in the literature of health professions education by inviting moments of reflection on medicine as seen through the lens of the arts and humanities. To ensure the ongoing success of the MATA feature in an ever-evolving digital landscape, we are announcing some updates to how we handle the artwork that forms the basis of all MATA pieces.
Each MATA piece comprises a work of art—a pa...
Source: Academic Medicine Blog - November 15, 2023 Category: Universities & Medical Training Authors: hgrimmaamc Tags: Journal Announcement Academic Medicine Medicine and the Arts Source Type: blogs
