A Role for the Gut Microbiome in the Aging of the Ovaries

As is the case for the thymus, aging and loss of function in the ovaries is interesting for (a) occurring at an accelerated pace relative to the rest of the body, and (b) producing meaningful downstream consequences in later life. What causes this comparatively early loss of function? Here, researchers look at changes in the balance of microbial populations in the gut microbiome as a contributing factor. The gut microbiome also shows age-related changes comparatively early in adult life, in which pro-inflammatory microbes expand in number whilst those producing beneficial metabolites decline in number. Altered composition and function of the gut microbiota play an important role in the pathogenesis of reproductive aging. Experimental and clinical studies have uncovered the relationship between gut dysbiosis and ovarian follicle development, as well as a disturbed immune response. Results from fecal microbiota transplant (FMT) studies provide a new insight to anti-ovarian aging, that is the maintenance of youthful gut microbiota helps to preserve ovarian function and prevent ovarian-related diseases. Microbiota-based intervention to delay or reserve ovarian aging is an appealing approach and may offer new therapeutic strategies for intestinal microbiota regulation to improve female fertility. Furthermore, investigation of antiaging interventions such as antiaging drugs and calorie restriction may improve the gut microbial imbalance and promote a healthier intes...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs