Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Long Term Exercise Improves Neurogenesis and Memory Function in Mice
Exercise is demonstrated to improve memory function, both immediately in the short-term, and over the long term of regular exercise and improved physical fitness. Exercise is also known to improve measures of neurogenesis, the creation of new neurons and integration into existing neural networks in the brain. This process is essential to learning and memory. Researchers here investigate the effects of exercise on neurogenesis in mice by labeling neurons in order to determine the contribution of adult neurogenesis to neural networks in the areas of the brain important to memory.
Exercise may prevent or delay aging-...
Source: Fight Aging! - May 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Transmission of Enteric Viruses through Saliva
by Gertrud U. Rey Norovirus and rotavirus are considered to be enteric pathogens because they are traditionally thought to be transmitted by the fecal-oral route; i.e., when consuming food prepared by someone who did not wash their hands properly after using the bathroom. Unlike rabies virus, which replicates in the salivary glands and transmits through […] (Source: virology blog)
Source: virology blog - August 4, 2022 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey enteric virus fecal-oral route IgA mammary glands norovirus rotavirus saliva salivary glands SIGA transmission Source Type: blogs
Odds and Ends
This article doesn ' t mention that at that time it also used a different ammunition than the original design which caused a lot of the problems.) These weapons are designed for one purpose only, and that is to kill Homo sapiens. The combination of very high muzzle velocity and a light, .223 caliber bullet does the job, because perhaps counterintuitively, the lighter bullet tumbles when it hits flesh and blows big holes in people, whereas heavier bullets go right through with much less damage. They actually account for a small share of gun violence in the U.S., but I would say they are culturally obnoxious. They ' re ...
Source: Stayin' Alive - June 3, 2022 Category: American Health Source Type: blogs
Xylological Delusions of Being a Tree
The mythology surroundingreverse inter-metamorphosis, a delusional syndrome that involves transformation into a beast, has frightened and fascinated for hundreds of years. A special instance of reverse inter-metamorphosis isclinical lycanthropy, the delusion that one has been transformed into a wolf (or another animal). A recent review identified 43 cases in the literature between 1852 and today (Guessoum et al., 2021). Psychotic depression and schizophrenia were the most common co-existing psychiatric diagnoses in these individuals.The article advocates a cultural and person-centered approach to treatment, as did many of ...
Source: The Neurocritic - October 31, 2021 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
Respect for Science
I vaguely remember discussing some of this before, but anyway . . . Throughout most of the 19th Century, despite the dramatic advances of science in many areas, nobody gained any useful understanding of human health and disease, and effective therapies were largely lacking. In fact, physicians -- medical school graduates -- advocated bloodletting and violent purging with mercury based emetics and laxatives. For obvious reasons, most people preferred other healing methods, which didn ' t work either but at least didn ' t kill you. Hospitals were just places where poor people went to die. So what happened to ...
Source: Stayin' Alive - July 5, 2021 Category: American Health Source Type: blogs
#ThisIsOurShot to end the pandemic [PODCAST]
“Vaccines have been around as early as 1776 when Edward Jenner first pioneered the smallpox vaccine and Louis Pasteur produced a rabies vaccine. As a microbiologist ’s child, I grew up hearing these stories from my father and thinking of these men as heroes. Vaccines have been proven so effective and safe that we are guilty […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 11, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast COVID-19 coronavirus Infectious Disease Source Type: blogs
What infectious diseases are due to be eradicated next?
Although Medical Science aims to eradicate Infectious Diseases in order to protect life and reduce the healthcare burden, it has only been able to achieve that goal against two diseases to date. While this remains a difficult task, there is a genuine possibility that additional diseases will be eliminated in the near future! Let’s explore the diseases that have been consigned to history…and those that are set to join them soon.
Smallpox: declared eradicated in 1980
Following a concentrated global effort spanning more than 20 years, Smallpox became the first infectious disease to be eradicated by mankind. S...
Source: GIDEON blog - December 23, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Source Type: blogs
Rabies – a dumb disease
Dog vaccination programs are the most effective way to prevent Rabies
Rabies is endemic to over 150 countries, and according to the World Health Organization, 99% of all transmissions to humans are from dogs, potentially bringing into question the animal’s status as the ‘man’s best friend’.
In Europe, southern Africa, and parts of North America, most cases are acquired from wild carnivores; mongooses, and vampire bats in Latin America and the Caribbean. In more recent years, humans have acquired rabies from inhalation of aerosols in bat caves, ingestion of dogs and cats for food, ticks, cart-scratches...
Source: GIDEON blog - September 28, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Source Type: blogs
Vaccines save lives
August is National Immunization Awareness Month (NIAM) and this year vaccines and immunology are probably on many more people’s minds than usual – for obvious reasons. While medical professionals and researchers work tirelessly on developing and testing a COVID-19 vaccine (amongst others), let’s briefly remind ourselves how far we have come in such a brief segment of human history.
224 years, 40 vaccines
The first vaccine, developed in 1796 for smallpox, was not put into mass production until many years later – but was a monumental breakthrough in Medicine. It took almost another 100 years before the next vaccines ...
Source: GIDEON blog - August 6, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: News Source Type: blogs
Vaccines for COVID-19 moving closer
As the world reels from illnesses and deaths due to COVID-19, the race is on for a safe, effective, long-lasting vaccine to help the body block the novel coronavirus SARS-CoV-2. The three vaccine approaches discussed here are among the first to be tested clinically in the United States.
How vaccines induce immunity: The starting line
In 1796, in a pastoral corner of England, and during a far more feudal and ethically less enlightened time, Edward Jenner, an English country surgeon, inoculated James Phipps, his gardener’s eight-year-old son, with cowpox pustules obtained from the arm of a milkmaid. It was widely believed ...
Source: Harvard Health Blog - July 21, 2020 Category: Consumer Health News Authors: Shiv Pillai, PhD, MBBS Tags: Coronavirus and COVID-19 Health Infectious diseases Vaccines Source Type: blogs
TWiV 625: Fred Murphy, virologist for all seasons
Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field. Click arrow to playDownload TWiV 625 (60 MB .mp3, 100 min)Subscribe (free): iTunes, Google Podcasts, RSS, email […] (Source: virology blog)
Source: virology blog - June 12, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ebolavirus Fred Murphy histopathology marburg virus rabies virus viral virology history viruses Source Type: blogs
Podcast: Don ’ t Let Coronavirus Impact Your Mental Health
It’s often said that fear is the most dangerous virus on the planet. While a relatively small percentage of people will contract the new coronavirus, or COVID-19, the fear it provokes will chip away at the mental health of nearly everyone who hears about it. So why does COVID-19 inspire so much fear when there are other diseases lurking in the shadows? And what can we do about it? In today’s podcast, our guest Dr. David Batman, a registered medical practitioner in the U.K., discusses how this high level of unprecedented global panic is being intensified by the non-stop media, and specifically, social media.
Tune i...
Source: World of Psychology - March 26, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: Anxiety and Panic General Health-related Interview Podcast The Psych Central Show Source Type: blogs
Computational Psychiatry, Self-Care, and The Mind-Body Problem
Schematic example of how the “mind” (cerebral cortex) is connected to the “body” (adrenal gland) - modified from Fig. 1 (Dum et al., 2016):“Modern medicine has generally viewed the concept of‘psychosomatic’disease with suspicion. This view arose partly because no neural networks were known for the mind, conceptually associated with the cerebral cortex, to influence autonomic and endocrine systems that control internal organs. ”Psychosomatic illnesses are typically seen in pejorative terms — it ' s all in your head so it must not be real! Would a known biological mechanism lessen the stigma? For over 40 ye...
Source: The Neurocritic - December 30, 2019 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
Treating Fingertip Amputations
Fingertip injuries and amputations are common in the emergency department, often occurring on weekends when consultants are not available. Some experienced physicians may consider rongeuring distal tuft amputation injuries, but simple closure and expert consultation for more difficult cases are suggested.A fingertip amputation within zone III involving total amputation of the distal tip, fingernail, matrix, and tuft. Photos by M. Roberts.Care of fingertip amputations in the ED should focus on removing debris and cleaning the wound as best as possible, closing the wound using available skin, bandaging and splinting for c...
Source: The Procedural Pause - December 5, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
