Vaccines for COVID-19 moving closer
As the world reels from illnesses and deaths due to COVID-19, the race is on for a safe, effective, long-lasting vaccine to help the body block the novel coronavirus SARS-CoV-2. The three vaccine approaches discussed here are among the first to be tested clinically in the United States. How vaccines induce immunity: The starting line In 1796, in a pastoral corner of England, and during a far more feudal and ethically less enlightened time, Edward Jenner, an English country surgeon, inoculated James Phipps, his gardener’s eight-year-old son, with cowpox pustules obtained from the arm of a milkmaid. It was widely believed at the time that once milkmaids became ill with cowpox, a relatively mild disease, they were no longer susceptible to smallpox. The young boy became quite ill, but recovered in about a week. Jenner then injected James with material from a smallpox pustule and observed that nothing untoward happened. A new scientific approach to disease prevention was born. A century later, it became clear that vaccination — a term Jenner coined from the Latin name for cowpox, Vaccinae variolae — worked because vaccines induce protective immune responses. We now know that vaccines can generate neutralizing antibodies by activating immune cells called B lymphocytes that secrete those molecules. Antibodies specifically recognize a shape on a virus or a toxin and bind to it, much like a key that tightly fits into a lock. They can then block the virus or toxin fro...
Publication date: 5 February 2021Source: Journal of Molecular Structure, Volume 1225Author(s): Abhijit Chhetri, Sailesh Chettri, Pranesh Rai, Dipu Kumar Mishra, Biswajit Sinha, Dhiraj Brahman
Publication date: Available online 24 September 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Ritika Kabra, Shailza Singh
Publication date: November 2020Source: Fish &Shellfish Immunology, Volume 106Author(s): Max J. Beckmann, Marcia Saraiva, Debbie McLaggan, Tom G. Pottinger, Pieter van West
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC04999A, CommunicationChristina A. McConville, Yunwen Tao, Hayden A. Evans, Benjamin A. Trump, Jonathan B. Lefton, Wenqian Xu, Andrey A. Yakovenko, Elfi Kraka, Craig M. Brown, Tom če Runčevski Here we report the phase diagram of acetonitrile and benzene with the focus on a 1 : 3 acetonitrile : benzene cocrystal relevant to mineralogy of Titan, Saturn's moon. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Analyst, 2020, Advance Article DOI: 10.1039/D0AN01609H, PaperSurasak Kasetsirikul, Muhammad Umer, Narshone Soda, Kamalalayam Rajan Sreejith, Muhammad J. A. Shiddiky, Nam-Trung Nguyen This work reports the development of a rapid, simple and inexpensive colorimetric paper-based assay for the detection of the severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) humanized antibody. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Analysis suggests too little attention is paid to gender disparities in medical trialsCoronavirus – latest updatesSee all our coronavirus coverageHistorically, medical research has often taken a one-size-fits-all approach, lumping women and men together despite growing evidence that the sexes differ in how they catch and fight disease.A stark example was the heart drug digoxin, which was widely marketed in the late 1990s on the basis of a trial that showed it to beeffective and safe. But over time a higher incidence of side-effects in women emerged. When the same dataset wasanalysed on the basis of sex, it showed dig...
WHO warns death tollcould be higher than 2 million without concerted action;Madrid braces for lockdown as Spain reaches 716,481 total infections;surge in cases in AthensFigures prompt French and Dutch warnings, and row in SpainUS approaches 7m cases as officials warn surge could comeWhat lessons can Europe learn from Sweden ’s experience?Why dogs might be a Covid tester ’s best friend7.50pmBSTOfficials have stopped a Covid-19 testing study in theUSafter multiple reports that state and federal public health workers were threatened and face racial slurs.The U.S. Centers for Disease Control and Prevention pulled f...
Integumen, a British company that developed a system to detect the COVID-19 virus in waste water, said the same technology could be deployed in a personalized breath test.Reuters Health Information
Authors: Mishra VN, Kumari N, Pathak A, Chaturvedi RK, Gupta AK, Chaurasia RN Abstract An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan City, China, in December 2019. Since then, the outbreak has grown into a global pandemic, and neither a vaccine nor a treatment for the disease, termed coronavirus disease 2019 (COVID-19), is currently available. The slow translational progress in the field of research suggests that a large number of studies are urgently required. In this context, this review explores the impact of bacteriophages on SARS-CoV-2, especially conce...
CONCLUSION: The results of the Committee work contribute to guide, support, value and defend nursing workers in coping with COVID-19. PMID: 32965404 [PubMed - in process]
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