A Bioinformatic Algorithm based on Pulmonary Endoarterial Biopsy for Targeted Pulmonary Arterial Hypertension Therapy
CONCLUSION: We describe a new potential paradigm in the therapy for PAH, which would include endoarterial biopsy, molecular analysis and tailored pharmacological therapy for patients with PAH.PMID:38655076 | PMC:PMC11037516 | DOI:10.2174/18743064-v17-230927-2023-9 (Source: Open Respiratory Medicine Journal)
Source: Open Respiratory Medicine Journal - April 24, 2024 Category: Respiratory Medicine Authors: Abraham Rothman David Mann Jose A Nunez Reinhardt Tarmidi Humberto Restrepo Valeri Sarukhanov Roy Williams William N Evans Source Type: research

Mild elevation of pulmonary vascular resistance predicts mortality regardless of mean pulmonary artery pressure in mild interstitial lung disease
Conclusions Mild elevation of PVR was associated with a higher mortality rate in patients with newly diagnosed ILD, even in those with MPAP≤20 mm Hg. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Sato, T., Furukawa, T., Teramachi, R., Fukihara, J., Yamano, Y., Yokoyama, T., Matsuda, T., Kataoka, K., Kimura, T., Sakamoto, K., Ishii, M., Kondoh, Y. Tags: Editor's choice, Thorax Interstitial lung disease Source Type: research

Atrial Fibrillation Ablation in Patients with Pulmonary Hypertension: Multicenter Experience
Pulmonary hypertension (PH) is a progressive condition characterized by pulmonary vascular remodeling and elevated pulmonary arterial pressure. Atrial arrhythmias are common in PH and may contribute to right ventricular failure and death1,2. We retrospectively identified patients with pre-capillary PH who underwent catheter ablation for AF at four high-volume ablation centers. Included patients had an established clinical diagnosis of PH, with suspected pre-capillary etiology, and at least one right heart catheterization showing mean pulmonary artery pressure>20 mm Hg and pulmonary capillary wedge pressure ≤15 mm Hg. (Source: Heart Rhythm)
Source: Heart Rhythm - April 13, 2024 Category: Cardiology Authors: Thomas A. Boyle, Bao Ha, Ikram Haq, Ammar Killu, Ritu Yadav, David Spragg, Christopher X. Wong, Babikir Kheiri, Joshua D. Moss, Francis E. Marchlinski, David S. Frankel Source Type: research

Surgical outcomes of the systemic-to-pulmonary artery shunt: risk factors of post-operative acute events and effectiveness of regulation of pulmonary blood flow with metal clips
ConclusionSurgical outcomes after SPS were acceptable and metal clip regulation of pulmonary blood flow appears to be safe and effective. PA/IVS was still a significant risk factor for acute events. (Source: General Thoracic and Cardiovascular Surgery)
Source: General Thoracic and Cardiovascular Surgery - April 13, 2024 Category: Cardiovascular & Thoracic Surgery Source Type: research

Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era
CONCLUSIONS: Our data display heterogeneity within the group of vasoresponders, with a large subset failing to show a sustained satisfactory clinical response to CCBs. This highlights the necessity for comprehensive reassessment during early follow-up. The use of pulmonary artery compliance in addition to current measures may better identify those likely to have a good long-term response.PMID:38606558 | DOI:10.1161/CIRCULATIONAHA.122.063821 (Source: Circulation)
Source: Circulation - April 12, 2024 Category: Cardiology Authors: Felix Gerhardt Eva Fiessler Karen M Olsson Moritz Z Kayser Gabor Kovacs Henning Gall H Ardeschir Ghofrani Roza Badr Eslam Irene M Lang Nicola Benjamin Ekkehard Gr ünig Michael Halank Tobias J Lange Silvia Ulrich Hanno Leuchte Matthias Held Hans Klose Ral Source Type: research

Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era
CONCLUSIONS: Our data display heterogeneity within the group of vasoresponders, with a large subset failing to show a sustained satisfactory clinical response to CCBs. This highlights the necessity for comprehensive reassessment during early follow-up. The use of pulmonary artery compliance in addition to current measures may better identify those likely to have a good long-term response.PMID:38606558 | DOI:10.1161/CIRCULATIONAHA.122.063821 (Source: Circulation)
Source: Circulation - April 12, 2024 Category: Cardiology Authors: Felix Gerhardt Eva Fiessler Karen M Olsson Moritz Z Kayser Gabor Kovacs Henning Gall H Ardeschir Ghofrani Roza Badr Eslam Irene M Lang Nicola Benjamin Ekkehard Gr ünig Michael Halank Tobias J Lange Silvia Ulrich Hanno Leuchte Matthias Held Hans Klose Ral Source Type: research

Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era
CONCLUSIONS: Our data display heterogeneity within the group of vasoresponders, with a large subset failing to show a sustained satisfactory clinical response to CCBs. This highlights the necessity for comprehensive reassessment during early follow-up. The use of pulmonary artery compliance in addition to current measures may better identify those likely to have a good long-term response.PMID:38606558 | DOI:10.1161/CIRCULATIONAHA.122.063821 (Source: Circulation)
Source: Circulation - April 12, 2024 Category: Cardiology Authors: Felix Gerhardt Eva Fiessler Karen M Olsson Moritz Z Kayser Gabor Kovacs Henning Gall H Ardeschir Ghofrani Roza Badr Eslam Irene M Lang Nicola Benjamin Ekkehard Gr ünig Michael Halank Tobias J Lange Silvia Ulrich Hanno Leuchte Matthias Held Hans Klose Ral Source Type: research

Congestion patterns in severe tricuspid regurgitation and transcatheter treatment: Insights from a multicentre registry
ConclusionIn this large cohort of invasively characterized patients undergoing TTVI, congestion patterns involving right-sided congestion were associated with low procedural success and higher mortality rates after TTVI. Whether pre-interventional reduction of right-sided congestion can improve outcomes after TTVI should be established in dedicated studies. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 4, 2024 Category: Cardiology Authors: Karl ‐Philipp Rommel, Guillaume Bonnet, Vera Fortmeier, Lukas Stolz, Anne R. Schöber, Jennifer von Stein, Mohammad Kassar, Muhammed Gerçek, Sebastian Rosch, Thomas J. Stocker, Maria I. Körber, Karl‐Patrik Kresoja, Tanja K. Rudolph, Rom Tags: Research Article Source Type: research

The Swan is not the Ugly Duckling
Pulmonary artery catheter (PAC) use has declined in the intensive care unit in recent decades due to two multicenter randomized controlled trials (The 433 patient ESCAPE1 trial and the 1,041 patient PAC-Man2 trial) that did not show benefit and an association with increased mortality in retrospective data. Without looking deeper into the methodology of those trials, it is easy to assume that PACs do not improve patient outcomes and should be avoided. Upon further examination however, these studies frequently do not apply to the modern cardiac intensive care (CCU) patient. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - April 3, 2024 Category: Cardiology Authors: Eric D. Warner, Mark Liotta, Normonique Dyer, Yevgeniy Brailovsky, Indranee N. Rajapreyar Tags: JCF Ignite! Source Type: research

ALCAPA in Children with Complex Congenital Heart Disease: A Multicenter Study
AbstractWe sought to report characteristics and outcomes of children with complex anomalous left coronary artery from the pulmonary artery (ALCAPA) and to  compare the outcomes to children with isolated ALCAPA. We performed a retrospective data analysis of children with ALCAPA who underwent cardiac surgery between 1/2009 and 3/2018 at 21 centers. Characteristics and outcomes of patients with complex ALCAPA are provided using descriptive statistics. O utcomes were compared between complex ALCAPA and isolated ALCAPA using Fisher’s exact test. We reviewed 258 patients who underwent surgical repair of ALCAPA at 21 centers. ...
Source: Pediatric Cardiology - April 3, 2024 Category: Cardiology Source Type: research

Outcomes With Hybrid Catheter-Directed Therapy Compared With Aspiration Thrombectomy for Patients With Intermediate-High Risk Pulmonary Embolism
ConclusionsHybrid CDT is a promising technique for the management of IHR PE with insufficient thrombus load reduction by CDMT.Trial RegistrationNCT0447356 —registration date 16 July 2020. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - April 2, 2024 Category: Cardiology Source Type: research

Factors Associated with Pulmonary Artery Catheter Use in Cardiogenic Shock Treated with Mechanical Circulatory Support
Purpose: Whether hospital type is associated with higher pulmonary artery catheter (PAC) use, in patients with cardiogenic shock (CS) treated with mechanical circulatory support (MCS) is unclear. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Datta, R. Smoller, S. Ahmad, S. Majdalawieh, D. Asemota, S. Rangasamy, M. Kamel, A. Sharma, M.J. Pierce, M. Alvarez Villela Source Type: research

Ultrasound Assessment of Pulmonary Artery Stiffening Associated with Pulmonary Hypertension in Left Heart Disease
Purpose: Diagnosis of pulmonary hypertension (PH) in patients with left heart disease (LHD) commonly occurs late in the disease process, as right heart catheterization is not routinely performed in LHD patients due to its inherent adverse effects. As such, there is an unmet clinical need for non-invasive techniques to detect and monitor PH in LHD. Having identified PA stiffening as both a pathomechanism and therapeutic target in PH-LHD in our previous work (Kucherenko et al, Nat. Comm. 2023), the current study aimed to develop a non-invasive index for the diagnosis of PA stiffening using a translational ultrasound-based ap...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Kukucka, P. Sang, N. Hegemann, F. Hennig, R. Yeter, T. Gransar, A. Mladenow, A. Emmerich, A. Orsenigo, J. Grune, V. Falk, W.M. Kuebler, C. Knosalla Source Type: research

Catheter-Directed Therapy to Treat Submassive Pulmonary Emboli in Single Lung Transplant Patients
We present two cases of acute submassive PE treated with catheter-directed therapy (CDT) in SLT recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Tomic, M. Venkata Subramani, C. Myers, J. Wright, A. Arunachalam, A. Joudi Source Type: research