Factors Associated with Pulmonary Artery Catheter Use in Cardiogenic Shock Treated with Mechanical Circulatory Support
Purpose: Whether hospital type is associated with higher pulmonary artery catheter (PAC) use, in patients with cardiogenic shock (CS) treated with mechanical circulatory support (MCS) is unclear. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Datta, R. Smoller, S. Ahmad, S. Majdalawieh, D. Asemota, S. Rangasamy, M. Kamel, A. Sharma, M.J. Pierce, M. Alvarez Villela Source Type: research

Ultrasound Assessment of Pulmonary Artery Stiffening Associated with Pulmonary Hypertension in Left Heart Disease
Purpose: Diagnosis of pulmonary hypertension (PH) in patients with left heart disease (LHD) commonly occurs late in the disease process, as right heart catheterization is not routinely performed in LHD patients due to its inherent adverse effects. As such, there is an unmet clinical need for non-invasive techniques to detect and monitor PH in LHD. Having identified PA stiffening as both a pathomechanism and therapeutic target in PH-LHD in our previous work (Kucherenko et al, Nat. Comm. 2023), the current study aimed to develop a non-invasive index for the diagnosis of PA stiffening using a translational ultrasound-based ap...
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , M. Kukucka, P. Sang, N. Hegemann, F. Hennig, R. Yeter, T. Gransar, A. Mladenow, A. Emmerich, A. Orsenigo, J. Grune, V. Falk, W.M. Kuebler, C. Knosalla Source Type: research

Catheter-Directed Therapy to Treat Submassive Pulmonary Emboli in Single Lung Transplant Patients
We present two cases of acute submassive PE treated with catheter-directed therapy (CDT) in SLT recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R. Tomic, M. Venkata Subramani, C. Myers, J. Wright, A. Arunachalam, A. Joudi Source Type: research

Cardiogenic shock diagnosis and management in general intensive care: a nationwide survey
CONCLUSIONS: According to this survey, there is no standardized approach to cardiogenic shock amongst Italian general intensive care units. The application of shock severity stratification and the treatment bundles may play a key role in improving the outcome.PMID:38551614 | DOI:10.23736/S0375-9393.24.17908-4 (Source: Minerva Anestesiologica)
Source: Minerva Anestesiologica - March 29, 2024 Category: Anesthesiology Authors: Costanza N Colombo Guido Tavazzi Michele Zanetti Francesca Dore Stefano Finazzi GiViTi Source Type: research

Respiratory gating improves correlation between pulse wave transit time and pulmonary artery pressure in experimental pulmonary hypertension
Objective. Since pulse wave transit time (PWTT) shortens as pulmonary artery pressure (PAP) increases it was suggested as a potential non-invasive surrogate for PAP. The state of tidal lung filling is also known to affect PWTT independently of PAP. The aim of this retrospective analysis was to test whether respiratory gating improved the correlation coefficient between PWTT and PAP. Approach. In each one of five anesthetized and mechanically ventilated pigs two high-fidelity pressure catheters were placed, one directly behind the pulmonary valve, and the second one in a distal branch of the pulmonary artery. PAP was raised...
Source: Physiological Measurement - March 29, 2024 Category: Physiology Authors: Fabian Mueller-Graf, Paul Frenkel, Jonas Merz, Susanne Reuter, Brigitte Vollmar, Gerardo Tusman, Sven Pulletz, Stephan H. B öhm, Amelie Zitzmann, Daniel A Reuter and Andy Adler Source Type: research

Metabolic changes contribute to maladaptive right ventricular hypertrophy in pulmonary hypertension beyond pressure overload: an integrative imaging and omics investigation
AbstractRight ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group. Animals were assessed at 1 and 8 months by right heart catheterization, cardiac magn...
Source: Basic Research in Cardiology - March 27, 2024 Category: Cardiology Source Type: research

Echocardiographic estimation of right ventricular diastolic stiffness based on pulmonary regurgitant velocity waveform analysis in precapillary pulmonary hypertension
This study aimed to compare echocardiography-derived RV diastolic stiffness and invasively measured pressure-volume loop-derived RV diastolic stiffness in patients with precapillary PH. We studied 50 consecutive patients with suspected or confirmed precapillary PH who underwent cardiac catheterization, magnetic resonance imaging, and echocardiography within a 1-week interval. Single-beat RV pressure-volume analysis was performed to determine the gold standard for RV diastolic stiffness. Elevated RV end-diastolic pressure (RVEDP) was defined as RVEDP  ≥ 8 mmHg. Using continuous-wave Doppler and M-mode echocardiography...
Source: The International Journal of Cardiovascular Imaging - March 27, 2024 Category: Radiology Source Type: research

Post-Pulmonary Embolism Syndrome: An Update Based on the Revised AWMF-S2k Guideline
Hamostaseologie. 2024 Mar 26. doi: 10.1055/a-2229-4190. Online ahead of print.ABSTRACTIn survivors of acute pulmonary embolism (PE), the post-PE syndrome (PPES) may occur. In PPES, patients typically present with persisting or progressive dyspnea on exertion despite 3 months of therapeutic anticoagulation. Therefore, a structured follow-up is warranted to identify patients with chronic thromboembolic pulmonary disease (CTEPD) with normal pulmonary pressure or chronic thromboembolic pulmonary hypertension (CTEPH). Both are currently understood as a dual vasculopathy, that is, secondary arterio- and arteriolopathy, affecting...
Source: Hamostaseologie - March 26, 2024 Category: Hematology Authors: F Joachim Meyer Christian Opitz Source Type: research

Post-Pulmonary Embolism Syndrome: An Update Based on the Revised AWMF-S2k Guideline
Hamostaseologie. 2024 Mar 26. doi: 10.1055/a-2229-4190. Online ahead of print.ABSTRACTIn survivors of acute pulmonary embolism (PE), the post-PE syndrome (PPES) may occur. In PPES, patients typically present with persisting or progressive dyspnea on exertion despite 3 months of therapeutic anticoagulation. Therefore, a structured follow-up is warranted to identify patients with chronic thromboembolic pulmonary disease (CTEPD) with normal pulmonary pressure or chronic thromboembolic pulmonary hypertension (CTEPH). Both are currently understood as a dual vasculopathy, that is, secondary arterio- and arteriolopathy, affecting...
Source: Hamostaseologie - March 26, 2024 Category: Hematology Authors: F Joachim Meyer Christian Opitz Source Type: research

Physiologic Effects of ECMO in Patients with Severe Acute Respiratory Distress Syndrome
CONCLUSIONS: In severe ARDS patients, increased ECMO blood flow rate resulting in higher SvO2 decreases pulmonary artery pressure, cardiac output, and right heart workload.PMID:38526489 | DOI:10.1164/rccm.202309-1688OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - March 25, 2024 Category: Intensive Care Authors: Elena Spinelli Marco Giani Douglas Slobod Bertrand Pavlovsky Michela di Pierro Stefania Crotti Alfredo Lissoni Giuseppe Foti Giacomo Grasselli Tommaso Mauri Source Type: research

Physiologic Effects of ECMO in Patients with Severe Acute Respiratory Distress Syndrome
CONCLUSIONS: In severe ARDS patients, increased ECMO blood flow rate resulting in higher SvO2 decreases pulmonary artery pressure, cardiac output, and right heart workload.PMID:38526489 | DOI:10.1164/rccm.202309-1688OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 25, 2024 Category: Respiratory Medicine Authors: Elena Spinelli Marco Giani Douglas Slobod Bertrand Pavlovsky Michela di Pierro Stefania Crotti Alfredo Lissoni Giuseppe Foti Giacomo Grasselli Tommaso Mauri Source Type: research