Pueraria mirifica alleviates cortical bone loss in naturally menopausal monkeys
This study indicated that postmenopausal monkeys continuously lose their cortical bone compartment, and they have a higher possibility for long bone fractures. Oral PMP treatment could improve both the bone quantity (BMC and BMD) and quality (bone geometry). (Source: Journal of Endocrinology)
Source: Journal of Endocrinology - October 5, 2016 Category: Endocrinology Authors: Kittivanichkul, D., Charoenphandhu, N., Khemawoot, P., Malaivijitnond, S. Tags: Research Source Type: research
Evaluation of in vivo estrogenic potency of natural estrogen-active chemical, puerarin, on pituitary function in gonadectomized female rats
Publication date: Available online 8 September 2016 Source:Life Sciences Author(s): Panida Loutchanwoot, Tina Vortherms, Hubertus Jarry Aims Previous research has revealed that puerarin, the major phytoestrogen in tuberous roots of Pueraria lobota and Pueraria mirifica, acts as a selective estrogen receptor modulator that displays predominantly estrogenic potential for health benefit. However, little is known about the estrogenic potency of puerarin in pituitary, especially in the rat model of postmenopausal females. Main methods Plasma prolactin and growth hormone levels as well as mRNA expression levels of pituitar...
Source: Life Sciences - September 8, 2016 Category: Biology Source Type: research
Proteome analysis of Pueraria mirifica tubers collected in different seasons.
Abstract
Pueraria mirifica-derived tuberous powder has been long-term consumed in Thailand as female hormone-replacement traditional remedies. The protein profiles of tubers collected in different seasons were evaluated. Phenol extraction, 2D-PAGE, and mass spectrometry were employed for tuberous proteome analysis. Out of the 322 proteins detected, over 59% were functionally classified as being involved in metabolism. The rest proteins were involved in defense, protein synthesis, cell structure, transportation, stress, storage, and also unidentified function. The proteins were found to be differentially ex...
Source: Bioscience, Biotechnology, and Biochemistry - March 4, 2016 Category: Biochemistry Authors: Jungsukcharoen J, Chokchaichamnankit D, Srisomsap C, Cherdshewasart W, Sangvanich P Tags: Biosci Biotechnol Biochem Source Type: research
Neurotherapeutic Effects of Pueraria mirifica Extract in Early‐ and Late‐Stage Cognitive Impaired Rats
We determined the neurotherapeutic effects of Pueraria mirifica extract (PME) and pure puerarin (PU) in comparison with 17β‐estradiol (E2) in early‐ and late‐stage cognitive impaired rats. Rats were ovariectomized (OVX), kept for 2 and 4 months to induce early‐ and late‐stage cognitive impairment, respectively, and divided into four groups that were treated daily with (i) distilled water, (ii) 100 mg/kg of PME, (iii) 7 mg/kg of PU, and (iv) 80 µg/kg of E2 for 4 months. The estrogen deficiency symptoms of OVX rats were abrogated by treatment with E2 or PME, but not by treatment with PU. The mRNA level ...
Source: Phytotherapy Research - February 1, 2016 Category: Biochemistry Authors: Kanya Anukulthanakorn, Ishwar S. Parhar, Sukanya Jaroenporn, Takashi Kitahashi, Gen Watanbe, Suchinda Malaivijitnond Tags: Research Article Source Type: research
Anti-osteoporotic effects of Pueraria candollei var. mirifica on bone mineral density and histomorphometry in estrogen-deficient rats
This study indicates that P. mirifica could be used as an anti-osteoporotic agent for postmenopausal women. Since P. mirifica could mainly retain bone mass at the levels before bone loss is initiated, the use of other anabolic agents in combination with P. mirifica is recommended for osteoporotic patients. (Source: Journal of Natural Medicines)
Source: Journal of Natural Medicines - January 27, 2016 Category: Drugs & Pharmacology Source Type: research
Chromene stability: The most potent estrogenic compounds in White Kwao Krua (Pueraria candollei var mirifica) crude extract
Publication date: December 2015 Source:Journal of Functional Foods, Volume 19, Part A Author(s): Orapin Udomsin, Thaweesak Juengwatanatrakul, Gorawit Yusakul, Waraporn Putalun Pueraria candollei var. mirifica (PM) is a phytoestrogen-rich herb with rejuvenating qualities. Stability of chromenes, comprising deoxymiroestrol, miroestrol and isomiroestrol, in crude extract of PM was investigated. The effects of acid-base condition and temperature on stability of the chromene standard solution and the PM crude extract were analysed using gradient HPLC. The degradation of the chromenes in the extract was sensitive to...
Source: Journal of Functional Foods - October 1, 2015 Category: Nutrition Source Type: research
Impact of Kudzu and Puerarin on Sperm Function
Publication date: Available online 28 March 2015 Source:Reproductive Toxicology Author(s): Sandra L. Gray , Brett R. Lackey , William R. Boone The goal of this study was to investigate the impact of kudzu (Pueraria mirifica) and the isoflavone puerarin in functional toxicological tests on spermatozoa and to assess the affinity of extracts and pure isoflavones for estrogen receptor (ER)–alpha and–beta (ERα, ERβ) in receptor binding assays. Capacitation, acrosome reaction and chromatin decondensation in spermatozoa were analyzed using microscopic analysis. Kudzu, but not puerarin, reduced motility of sperm. Puer...
Source: Reproductive Toxicology - March 31, 2015 Category: Toxicology Source Type: research
Preventive effect of Pueraria mirifica on testosterone‐induced prostatic hyperplasia in Sprague Dawley rats
In this study, we investigated the protective effect of PM extract, daidzein and genistein on a testosterone‐induced prostatic hyperplasia in rats. Testosterone was administered at 3 mg kg−1 to rats followed by the PM extract, daidzein and genistein for a period of 30 days with finasteride as positive control. The testosterone level was increased, indicating inhibition of 5α‐reductase converting testosterone to dihydrotestosterone. This was confirmed by prostate‐specific antigen level that significantly decreased when treated with PM extract, daidzein and genistein. The PM extract, daidzein and genistein reduce...
Source: Andrologia - January 20, 2015 Category: Urology & Nephrology Authors: S. S. Masrudin, J. Mohamad Tags: Original Article Source Type: research
Pueraria mirifica extract and puerarin enhance proliferation and expression of alkaline phosphatase and type I collagen in primary baboon osteoblasts
In conclusion, we have established baboon primary osteoblast culture, which is a new tool for bone research and drug discovery. Furthermore, the present results provide substantial support for the potential of PM extract and its phytoestrogens to be developed as therapeutic agents against bone fragility. (Source: Phytomedicine)
Source: Phytomedicine - October 15, 2014 Category: Drugs & Pharmacology Authors: Wacharaporn Tiyasatkulkovit, Suchinda Malaivijitnond, Narattaphol Charoenphandhu, Lorena M. Havill, Allen L. Ford, John L. VandeBerg Tags: Original Article Source Type: research
