A Nanomaterial Incorporating TNF Epitopes Reduces Inflammation
The inflammatory cytokine TNF is the target of many efforts to find ways to reduce inflammation in conditions characterized by excessive inflammatory activity of the immune system, such as autoimmune diseases. It is a blunt approach, as it reduces not only inappropriate activity, but also the needed activity of the immune system, such as defense against pathogens and destruction of potentially cancerous and senescent cells. The methods of targeting TNF are becoming ever more sophisticated, as this example demonstrates. It is nonetheless the case that better and different classes of treatment will be needed in order to avoi...
Source: Fight Aging! - April 22, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Stress may be getting to your skin, but it ’s not a one-way street
Are you stressed out? Your skin can show it. Studies show that both acute and chronic stress can exert negative effects on overall skin wellness, as well as exacerbate a number of skin conditions, including psoriasis, eczema, acne, and hair loss.
But it’s not just a one-way street. Research has also shown that skin and hair follicles contain complex mechanisms to produce their own stress-inducing signals, which can travel to the brain and perpetuate the stress response.
Stress and the two-way street between your brain and skin
You may already have experienced the connection between the brain and skin. Have you ever gotte...
Source: Harvard Health Blog - April 14, 2021 Category: Consumer Health News Authors: Neera Nathan, MD, MSHS Tags: Skin and Hair Care Stress Source Type: blogs
Wouldn ’ t you love to see this ad run during TV morning news?
Watch TV morning news and nearly half the commercials are direct-to-consumer (DTC) drug ads. Watch evening news and you will likewise be inundated by drug commercials. They all follow the same script: People living their lives, having fun, happy, while the potential side-effects of these drugs are recited. The happy visuals serve to make the side-effects mentioned seem remote.
So I thought we should parody a DTC drug ad. This is not for any drug; it’s for how to avoid being exploited by the healthcare system and by doctors. Sure, we need them when there is injury, infection, or a genetic condition. For the vas...
Source: Wheat Belly Blog - March 29, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open undoctored wheat belly Source Type: blogs
Happify Health raises $73M to deepen partnerships with pharmaceutical companies and insurance payers
Happify Health raises $73M to expand its digital therapeutic care delivery capabilities (MobiHealth News):
Founded in 2012, Happify is best known for digital programs that provided automated self-guided support across various areas of mental health and wellness, such as stress management for employees or health plan members. Should the user need additional support, the platform can also facilitate a referral to third-party coaching, therapy, telemedicine or other available resources.
In more recent years the platform has expanded to address more than a dozen other chronic conditions, such as heart health and psoriasis, tha...
Source: SharpBrains - March 17, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health Technology & Innovation artificial intelligence digital therapeutic solutions digital therapeutics Happify Happify Health mental-wellness pharmaceutical stress-management Source Type: blogs
Innovation in treatment for people with rarer or less well-recognised long-term conditions
The King's Fund - This paper, commissioned by UCB, investigates how five leading specialist hospital services in the UK are innovating in care for people with severe psoriasis, inflammatory bowel disease (IBD), axial spondyloarthritis, osteoporosis and combinations of inflammatory conditions.ReportMore detail (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - February 1, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Quality of care and clinical outcomes Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Clinical Evidence for NAD+ Upregulation
I recently collaborated on a review paper covering the history of clinical work on upregulation of nicotinamide adenine dinucleotide (NAD) as an approach to therapy. This is of interest to the aging research community because NAD is important to mitochondrial function. NAD levels diminish with age, alongside a loss of mitochondrial function that is known to contribute to the onset and progression of many age-related conditions. Animal studies and a few clinical trials have indicated that increased NAD levels may improve, for example, cardiovascular function in older individuals, as a result of improved mitochondrial functi...
Source: Fight Aging! - September 22, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reducing Chronic Inflammation as Effective as Reducing Blood Cholesterol in Producing a Small Reversal of Atherosclerotic Lesions
This study provides characterization of a lipid-rich necrotic core, a dangerous type of coronary plaque made up of dead cells and cell debris that is prone to rupture. Ruptured plaque can lead to a heart attack or stroke.
The analysis involved 209 middle-aged patients (ages 37-62) with psoriasis who participated in the Psoriasis Atherosclerosis Cardiometabolic Initiative at the National Institutes of Health, an ongoing observational study. Of these participants, 124 received biologic therapy, and 85 were in the control group, treated only with topical creams and light therapy. To measure the effects of biologic ther...
Source: Fight Aging! - September 22, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
9 Tips to Manage Stress for Better Health
Photo credit Jared Rice
Increasingly, stress is considered a risk factor for dementia, particularly Alzheimer’s. Stress is also a risk factor for stroke and heart attack as well as a trigger for many diseases from arthritis to psoriasis. Obviously, limiting stress in our lives is a good idea. But how? Simply living what we call modern life seems to make stress the norm.
View slideshow on HealthCentral for more insight into managing stress:
Purchase Minding Our Elders: Caregivers Share Their Personal Stories – paperback or ebook
Incontinence problems? Try Egosan premium underwear for discrete, dignified protecti...
Source: Minding Our Elders - September 11, 2020 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Cardiac complications of psoriasis
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - August 12, 2020 Category: Internal Medicine Tags: cardiovascular dermatology Source Type: blogs
Fight Aging! Newsletter, July 27th 2020
In this study, we applied a well studied prediction model developed on data from five CpG sites, to increase the practicability of these tests.
We have determined the biological age of the heart, specifically of the right atrium (RA) and left atrium (LA), and of peripheral blood leucocytes, by measuring the mitotic telomere length (TL) and the non-mitotic epigenetic age (DNAmAge). We found that DNAmAge, of both atrial tissues (RA and LA), was younger in respect to the chronological age (-12 years). Furthermore, no significant difference existed between RA and LA, suggesting that, although anatomically diverse and ex...
Source: Fight Aging! - July 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The OneSkin Technologies DNA Methylation Clock for Assessment of Skin Aging
OneSkin Technologies is one of the first generation of startup biotech companies in the longevity industry; you'll find an overview of their programs and technology in an interview with founder Carolina Reis last year. In summary, OneSkin works on both improved models of aging skin, and topical senolytic compounds capable of selectively destroying the senescent cells thought to be responsible for a sizable fraction of skin aging in later life. Unlike other companies in the longevity industry, the OneSkin staff is focused on the cosmetics regulatory path to market. This is in some ways more limited, and in other ways much c...
Source: Fight Aging! - July 22, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Do plant extracts work in skin care products – episode 222
Welcome to the Beauty Brains, a show where real cosmetic chemists answer your beauty product questions and give you an insider’s look at the cosmetic industry. This is Episode 222. Yes, that’s a palindrome! Yeah. I’m your host, Perry Romanowski and with me today is…well, it’s just me. Valerie is off today but she’ll be back next week.
Meanwhile on today’s show I’m going to be answering questions about…
Whether the SkinDupes AI is a reliable way to pick skin care products?
Can you combine Vitamin C and Niacinamide?
Do blue light serums provide any extra benefit?
Whether it’s worth it to gro...
Source: thebeautybrains.com - May 30, 2020 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast Source Type: blogs
Do plant extracts work in skin care products – episode 222
Welcome to the Beauty Brains, a show where real cosmetic chemists answer your beauty product questions and give you an insider’s look at the cosmetic industry. This is Episode 222. Yes, that’s a palindrome! Yeah. I’m your host, Perry Romanowski and with me today is…well, it’s just me. Valerie is off today but she’ll be back next week.
Meanwhile on today’s show I’m going to be answering questions about…
Whether the SkinDupes AI is a reliable way to pick skin care products?
Can you combine Vitamin C and Niacinamide?
Do blue light serums provide any extra benefit?
Whether it’s worth it to gro...
Source: thebeautybrains.com - May 30, 2020 Category: Consumer Health News Authors: Perry Romanowski Tags: Podcast Source Type: blogs
Fight Aging! Newsletter, April 27th 2020
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia.
To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence?
https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/
Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go...
Source: Fight Aging! - April 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
