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Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research

Therapeutic management of fibrosis in systemic sclerosis patients - an analysis from the Swiss EUSTAR cohort
CONCLUSION: Overall, in Switzerland, a wide range of medications is prescribed for systemic sclerosis patients. This includes modern, targeted treatments for which randomised controlled clinical trial have been recently reported.PMID:38579324 | DOI:10.57187/s.3630 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Kevin Windirsch Suzana Jordan Mike Oliver Becker Cosimo Bruni Rucsandra Dobrota Muriel Elhai Ion-Alexandru Garaiman Carmen-Marina Mihai Michele Iudici Paul Hasler Camillo Ribi Britta Maurer Armando Gabrielli Anna-Maria Hoffmann-Vold Oliver Distler Source Type: research

Clinical manifestation, lifestyle, and treatment patterns of chronic erosive gastritis: A multicenter real-world study in China
CONCLUSION: CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms. Gastroscopy may play a major role in its detection and diagnosis. Treatment should be individualized based on symptom profile.PMID:38577179 | PMC:PMC10989489 | DOI:10.3748/wjg.v30.i9.1108 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Ying-Yun Yang Ke-Min Li Gui-Fang Xu Cheng-Dang Wang Hua Xiong Xiao-Zhong Wang Chun-Hui Wang Bing-Yong Zhang Hai-Xing Jiang Jing Sun Yan Xu Li-Juan Zhang Hao-Xuan Zheng Xiang-Bin Xing Liang-Jing Wang Xiu-Li Zuo Shi-Gang Ding Rong Lin Chun-Xiao Chen Xing-We Source Type: research

Treatment of < em > Helicobacter pylori < /em > with potassium competitive acid blockers: A systematic review and meta-analysis
CONCLUSION: VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy.PMID:38577188 | PMC:PMC10989498 | DOI:10.3748/wjg.v30.i9.1213 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Joseph Edwin Kanu Jonathan Soldera Source Type: research

Clinical manifestation, lifestyle, and treatment patterns of chronic erosive gastritis: A multicenter real-world study in China
CONCLUSION: CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms. Gastroscopy may play a major role in its detection and diagnosis. Treatment should be individualized based on symptom profile.PMID:38577179 | PMC:PMC10989489 | DOI:10.3748/wjg.v30.i9.1108 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Ying-Yun Yang Ke-Min Li Gui-Fang Xu Cheng-Dang Wang Hua Xiong Xiao-Zhong Wang Chun-Hui Wang Bing-Yong Zhang Hai-Xing Jiang Jing Sun Yan Xu Li-Juan Zhang Hao-Xuan Zheng Xiang-Bin Xing Liang-Jing Wang Xiu-Li Zuo Shi-Gang Ding Rong Lin Chun-Xiao Chen Xing-We Source Type: research

Vonoprazan-based versus proton pump inhibitor-based therapy in Helicobacter pylori eradication: an updated systematic review and meta-analysis of randomised trials
We read the Maastricht VI/Florence consensus report published in GUT with great interest.1 The report suggested that vonoprazan-based therapy is superior, or not inferior, to conventional proton pump inhibitor (PPI)-based triple therapies for Helicobacter pylori eradication.1 However, the number of randomised controlled trials (RCTs) was small and the majority of previous trials were conducted in Japan.2–5 Recently, several new RCTs from other populations have been reported.6–8 Therefore, we conducted an updated systematic review and meta-analysis of RCTs to compare the efficacy and tolerability of vonoprazan a...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Chen, P.-Y., Tsai, F.-P., Chen, M.-J., Yang, H.-Y., Wu, M.-S., Liou, J.-M. Tags: Gut PostScript Source Type: research

Comparison of Vonoprazan versus Intravenous Proton Pump Inhibitor for Prevention of High-Risk Peptic Ulcers Rebleeding after Successful Endoscopic Hemostasis: A Multicenter Randomized Noninferiority Trial
This study aims to compare the efficacy of vonoprazan versus PPI for preventing high-risk PU rebleeding after hemostasis. (Source: Gastroenterology)
Source: Gastroenterology - April 4, 2024 Category: Gastroenterology Authors: Tanawat Geeratragool, Uayporn Kaosombatwattana, Arpapun Boonchote, Suvikrom Chatthammanat, Nutchanun Preechakawin, Jompol Srichot, Asawin Sudcharoen, Pavapol Sirisunhirun, Panotpol Termsinsuk, Manus Rugivarodom, Julajak Limsrivilai, Monthira Maneerattanap Tags: Clinical - Alimentary Tract Source Type: research

The association between proton pump inhibitor use and systemic anti-tumour therapy on survival outcomes in patients with advanced non-small cell lung cancer: A systematic review and meta-analysis
Br J Clin Pharmacol. 2024 Apr 3. doi: 10.1111/bcp.16060. Online ahead of print.NO ABSTRACTPMID:38570720 | DOI:10.1111/bcp.16060 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 3, 2024 Category: Cancer & Oncology Source Type: research

Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention
Paediatr Drugs. 2024 Apr 2. doi: 10.1007/s40272-024-00626-w. Online ahead of print.ABSTRACTNecrotizing enterocolitis (NEC) is a life-threatening disease predominantly affecting premature and very low birth weight infants resulting in inflammation and necrosis of the small bowel and colon and potentially leading to sepsis, peritonitis, perforation, and death. Numerous research efforts have been made to better understand, treat, and prevent NEC. This review explores a variety of factors involved in the pathogenesis of NEC (prematurity, low birth weight, lack of human breast milk exposure, alterations to the microbiota, mater...
Source: Paediatric Drugs - April 2, 2024 Category: Pediatrics Authors: Annette Gawron Roberts Noelle Younge Rachel Gottron Greenberg Source Type: research