Immune-globulin
(Source: Reactions Weekly)
Source: Reactions Weekly - October 1, 2023 Category: Drugs & Pharmacology Source Type: research
Real-World Use, Safety, and Patient Experience of 20% Subcutaneous Immunoglobulin for Primary Immunodeficiency Diseases
CONCLUSION: The CORE study provides real-world evidence of the flexibility, feasibility, safety, and tolerability of Ig20Gly infusions, at mostly weekly intervals, over 1 year in patients with PIDs.TRIAL REGISTRATION: German Clinical Trials Register, DRKS00014562. Registered April 9, 2018, https://drks.de/search/en/trial/DRKS00014562.PMID:37751025 | DOI:10.1007/s12325-023-02649-0 (Source: Adv Data)
Source: Adv Data - September 26, 2023 Category: Epidemiology Authors: Maria Fasshauer Michael Borte Michaela Bitzenhofer Christine Pausch David Pittrow Michelle Park Andr é Gladiator Peter Jandus Source Type: research
Thrombocytopenia Associated with Elemental Mercury Poisoning in Two Siblings - Connecticut, July 2022
MMWR Morb Mortal Wkly Rep. 2023 Sep 22;72(38):1027-1031. doi: 10.15585/mmwr.mm7238a2.ABSTRACTTwo siblings aged 5 and 15 years from Connecticut were hospitalized with petechial rash, oral mucositis, and severe thrombocytopenia approximately 10 days after they played with a jar of elemental mercury they found in their home. Before the mercury exposure was disclosed, the siblings were treated with platelet transfusions, intravenous immune globulin (IVIG) for possible immune thrombocytopenic purpura, and antibiotics for possible infectious causes. When their conditions did not improve after 6 days, poison control facilitated f...
Source: MMWR Morb Mortal Wkl... - September 21, 2023 Category: Epidemiology Authors: Emily W Hogeland Tarah S Somers Luke Yip Suzanne Doyon Carrie A Redlich Andrea D Orsey Craig B Woda Suzannah T Swan Henry M Feder Source Type: research
Thrombocytopenia Associated with Elemental Mercury Poisoning in Two Siblings - Connecticut, July 2022
MMWR Morb Mortal Wkly Rep. 2023 Sep 22;72(38):1027-1031. doi: 10.15585/mmwr.mm7238a2.ABSTRACTTwo siblings aged 5 and 15 years from Connecticut were hospitalized with petechial rash, oral mucositis, and severe thrombocytopenia approximately 10 days after they played with a jar of elemental mercury they found in their home. Before the mercury exposure was disclosed, the siblings were treated with platelet transfusions, intravenous immune globulin (IVIG) for possible immune thrombocytopenic purpura, and antibiotics for possible infectious causes. When their conditions did not improve after 6 days, poison control facilitated f...
Source: MMWR Morb Mortal Wkl... - September 21, 2023 Category: Epidemiology Authors: Emily W Hogeland Tarah S Somers Luke Yip Suzanne Doyon Carrie A Redlich Andrea D Orsey Craig B Woda Suzannah T Swan Henry M Feder Source Type: research
Thrombocytopenia Associated with Elemental Mercury Poisoning in Two Siblings - Connecticut, July 2022
MMWR Morb Mortal Wkly Rep. 2023 Sep 22;72(38):1027-1031. doi: 10.15585/mmwr.mm7238a2.ABSTRACTTwo siblings aged 5 and 15 years from Connecticut were hospitalized with petechial rash, oral mucositis, and severe thrombocytopenia approximately 10 days after they played with a jar of elemental mercury they found in their home. Before the mercury exposure was disclosed, the siblings were treated with platelet transfusions, intravenous immune globulin (IVIG) for possible immune thrombocytopenic purpura, and antibiotics for possible infectious causes. When their conditions did not improve after 6 days, poison control facilitated f...
Source: MMWR Morb Mortal Wkl... - September 21, 2023 Category: Epidemiology Authors: Emily W Hogeland Tarah S Somers Luke Yip Suzanne Doyon Carrie A Redlich Andrea D Orsey Craig B Woda Suzannah T Swan Henry M Feder Source Type: research
Thrombocytopenia Associated with Elemental Mercury Poisoning in Two Siblings - Connecticut, July 2022
MMWR Morb Mortal Wkly Rep. 2023 Sep 22;72(38):1027-1031. doi: 10.15585/mmwr.mm7238a2.ABSTRACTTwo siblings aged 5 and 15 years from Connecticut were hospitalized with petechial rash, oral mucositis, and severe thrombocytopenia approximately 10 days after they played with a jar of elemental mercury they found in their home. Before the mercury exposure was disclosed, the siblings were treated with platelet transfusions, intravenous immune globulin (IVIG) for possible immune thrombocytopenic purpura, and antibiotics for possible infectious causes. When their conditions did not improve after 6 days, poison control facilitated f...
Source: MMWR Morb Mortal Wkl... - September 21, 2023 Category: Epidemiology Authors: Emily W Hogeland Tarah S Somers Luke Yip Suzanne Doyon Carrie A Redlich Andrea D Orsey Craig B Woda Suzannah T Swan Henry M Feder Source Type: research
Thrombocytopenia Associated with Elemental Mercury Poisoning in Two Siblings - Connecticut, July 2022
MMWR Morb Mortal Wkly Rep. 2023 Sep 22;72(38):1027-1031. doi: 10.15585/mmwr.mm7238a2.ABSTRACTTwo siblings aged 5 and 15 years from Connecticut were hospitalized with petechial rash, oral mucositis, and severe thrombocytopenia approximately 10 days after they played with a jar of elemental mercury they found in their home. Before the mercury exposure was disclosed, the siblings were treated with platelet transfusions, intravenous immune globulin (IVIG) for possible immune thrombocytopenic purpura, and antibiotics for possible infectious causes. When their conditions did not improve after 6 days, poison control facilitated f...
Source: MMWR Morb Mortal Wkl... - September 21, 2023 Category: Epidemiology Authors: Emily W Hogeland Tarah S Somers Luke Yip Suzanne Doyon Carrie A Redlich Andrea D Orsey Craig B Woda Suzannah T Swan Henry M Feder Source Type: research
Thrombocytopenia Associated with Elemental Mercury Poisoning in Two Siblings - Connecticut, July 2022
MMWR Morb Mortal Wkly Rep. 2023 Sep 22;72(38):1027-1031. doi: 10.15585/mmwr.mm7238a2.ABSTRACTTwo siblings aged 5 and 15 years from Connecticut were hospitalized with petechial rash, oral mucositis, and severe thrombocytopenia approximately 10 days after they played with a jar of elemental mercury they found in their home. Before the mercury exposure was disclosed, the siblings were treated with platelet transfusions, intravenous immune globulin (IVIG) for possible immune thrombocytopenic purpura, and antibiotics for possible infectious causes. When their conditions did not improve after 6 days, poison control facilitated f...
Source: MMWR Morb Mortal Wkl... - September 21, 2023 Category: Epidemiology Authors: Emily W Hogeland Tarah S Somers Luke Yip Suzanne Doyon Carrie A Redlich Andrea D Orsey Craig B Woda Suzannah T Swan Henry M Feder Source Type: research
The benefit of intravenous immune globulin in the treatment of delayed radiation myelopathy
AbstractDelayed radiation myelopathy (DRM) is a rare yet severe complication of radiotherapy. This condition has a progressive pattern that is often irreversible. Several therapeutic strategies have been introduced to alleviate disease complications, including corticosteroids, hyperbaric oxygen, anticoagulants, and antivascular endothelial gro wth factor (VEGF) agents. However, despite their beneficial effect, they have not been the definitive treatments for DRM. Here we present the case of a 55-year-old woman with a history of multiple myeloma who developed neurological complications 11 months after radiation therap...
Source: Strahlentherapie und Onkologie - September 19, 2023 Category: Cancer & Oncology Source Type: research
Acute motor-sensory axonal polyneuropathy variant of Guillain-Barr é syndrome with a thalamic lesion and COVID-19: a case report and discussion on mechanism
ConclusionThe AMSAN variant of GBS secondary to COVID-19 infection is severe and can cause extensive damage to the peripheral nerves system. The deterioration of symptoms in the patient after early immunotherapy may indicate treatment-related fluctuation (TRF) and could be attributed to immune rebound. Moreover, an excessive immune response post-COVID-19 infection may trigger concurrent damage to the central nervous system, indicating secondary harm to brain small blood vessels and nerve units. For suspected cases of GBS complicated by COVID-19, it is essential to conduct early brain MRI examinations in addition to routine...
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research
Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report
ConclusionThis case highlights the possibility of vaccine-induced thrombotic thrombocytopenia occurrence by whole-virus coronavirus disease 2019 vaccines. Compared with vector-based vaccines, this phenomenon is rare for whole-virus vaccines. More studies on this type of vaccine regarding thrombotic thrombocytopenia should be considered. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - September 8, 2023 Category: General Medicine Source Type: research
Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus)
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Aug 21:109731. doi: 10.1016/j.cbpc.2023.109731. Online ahead of print.ABSTRACTIn photoperiod-sensitive wild animals, the secretion of melatonin (MT) is modulated by external photoperiod, and MT affects inflammation and the ageing process. The beneficial effects of MT in delaying the progress of ageing have been reported in laboratory mice and rats. However, little is known about MT in wild mammals. In the current study, we investigated energy metabolism, microbial community structure and colon homeostasis in ageing Mongolian gerbils (Meriones unguiculatus) through exogenous su...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - August 23, 2023 Category: Biochemistry Authors: Wen-Ting Gao Jin-Xiu Liu De-Hua Wang Hai-Ji Sun Xue-Ying Zhang Source Type: research
Emerging pharmacological strategies for treating and preventing mpox
Expert Rev Clin Pharmacol. 2023 Aug 17. doi: 10.1080/17512433.2023.2249820. Online ahead of print.ABSTRACTINTRODUCTION: Since May 2022, there have been nearly 87,000 documented cases of mpox worldwide, with 119 deaths. Pharmacological interventions for mpox include the MVA-BN smallpox vaccine, tecovirimat, cidofovir or its pro-drug brincidofovir, and vaccinia immune globulin intravenous (VIGIV).AREAS COVERED: The literature search and information gathering for this review included the PubMed database focusing on mpox and monkeypox, in combination with tecovirimat, brincidofovir, cidofovir, VIGIV, and smallpox vaccine. WHO....
Source: Pharmacological Reviews - August 18, 2023 Category: Drugs & Pharmacology Authors: Douglas W Grosenbach Andrew T Russo Emily D Blum Dennis E Hruby Source Type: research
