Society for Maternal-Fetal Medicine Statement: RhD immune globulin after spontaneous or induced abortion less than 12 weeks of gestation
Guidelines for management of first-trimester spontaneous and induced abortion vary regarding RhD testing and Rho(D) immune globulin administration. These existing guidelines are based on limited data that do not convincingly demonstrate the safety of withholding Rho(D) immune globulin for first-trimester abortions or pregnancy losses. Given the adverse fetal and neonatal outcomes associated with RhD alloimmunization, prevention of maternal sensitization is essential in RhD negative patients who may experience subsequent pregnancies. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 26, 2024 Category: OBGYN Authors: Society for Maternal-Fetal Medicine (SMFM), Malavika Prabhu, Judette M. Louis, Jeffrey A. Kuller, SMFM Publications Committee Tags: SMFM Statement Source Type: research

Guide to Rho(D) Immune Globulin in Women With Molecularly Defined Asian-type DEL (c.1227G & gt;A)
We report that mothers with molecularly defined Asian-type DEL, similar to those with weak D types 1, 2, 3, 4.0, and 4.1, do not require RhIG before and after delivery. Collectively, this review could pave the way for the revision of international guidelines to include the selective use of RhIG based on specific genotypes, particularly in women with the Asian-type DEL.PMID:38384203 | DOI:10.3343/alm.2023.0356 (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - February 22, 2024 Category: Laboratory Medicine Authors: In Hwa Jeong SooHo Yu Tae Yeul Kim Soo-Young Oh Duck Cho Source Type: research

A Case of Intractable Hypophosphatemia in a Patient with Guillain-Barr é Syndrome and Encephalitis after SARS-CoV-2 Infection
CONCLUSION: Early diagnosis is important for the management of Guillain-Barré syndrome associated with SARS-CoV-2 infection. Moreover, in order to prevent life-threatening long-term persistent electrolyte disturbances in non-seriously ill patients, clinicians should pay particular attention to their electrolyte status.PMID:38314683 | DOI:10.2174/0118715303261924231117055702 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 5, 2024 Category: Endocrinology Authors: Yawen Zheng Yuanyuan Hou Mingzhu Qi Yongxiang Zhang Chao Han Hui Sun Jiang Li Source Type: research

A Case of Intractable Hypophosphatemia in a Patient with Guillain-Barr é Syndrome and Encephalitis after SARS-CoV-2 Infection
CONCLUSION: Early diagnosis is important for the management of Guillain-Barré syndrome associated with SARS-CoV-2 infection. Moreover, in order to prevent life-threatening long-term persistent electrolyte disturbances in non-seriously ill patients, clinicians should pay particular attention to their electrolyte status.PMID:38314683 | DOI:10.2174/0118715303261924231117055702 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 5, 2024 Category: Drugs & Pharmacology Authors: Yawen Zheng Yuanyuan Hou Mingzhu Qi Yongxiang Zhang Chao Han Hui Sun Jiang Li Source Type: research

Immune Globulin Subcutaneous 16.5% in Treatment of Primary Immunodeficiency: A Two-Year, Multi-Center Analysis
Immune Globulin Subcutaneous (Human) 16.5% (IGSC 16.5%) is approved for the treatment of primary immunodeficiency diseases (PID) in adults and pediatric patients ≥2 years but long term data is lacking. We evaluated efficacy and safety of IGSC 16.5% in patients over a 2-year time period. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Richard Herrscher, Jeffrey Langford, Precious Anyanwu, Lucinda VanAnglen Source Type: research

Absence of blood donors ’ anti-SARS-CoV-2 antibodies in pre-storage leukoreduced red blood cell units indicates no role of passive immunity for blood recipients
This study shows deplasmation and leukodepletion of RBC units ensured removal of IgG content and no red blood cell unit was reactive for anti-COVID-19 antibodies even from donors with high serum titre. These findings demonstrate that deplasmated and leukodepleted RBCs are not to be considered bloo d products containing substantial amounts of immune globulin, and differently from other blood derived-products containing Ab, transfusions with deplasmated and leukodepleted RBCs do not require delayed vaccinations and a revision of current recommendations is requested. (Source: Annals of Hematology)
Source: Annals of Hematology - January 20, 2024 Category: Hematology Source Type: research

Successful management of severe Kell alloimmunization in pregnancy with intravenous immune globulin
Hemolytic Disease of the Fetus and Newborn (HDFN) is a condition that affects 1 to 2 out of 1000 patients during pregnancy (1). When an alloantibody is present, it is essential to identify its nature in order to organize appropriate follow-up. Kell-mediated HDFN is rare; it occurs in about 5% of Kell alloimmunized pregnant women. It is important to note that in case of anti-Kell immunization, the severity of HDFN is not correlated with maternal antibody titers, and anemia tends to occur earlier and more severely. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - January 5, 2024 Category: Hematology Authors: Marie Patris, Anne Holoye, Deborah Goldman, Caroline De Coninck, Martin Colard Tags: Case Report Source Type: research

Macrophage activation syndrome with acute hepatitis in a patient with adult-onset immunodeficiency with anti-interferon gamma antibodies: a case report
ConclusionThis case highlights the importance of maintaining macrophage activation syndrome on the differential of a patient with acute hepatitis of unknown etiology in the correct clinical context and the value of a liver biopsy in making a diagnosis when noninvasive testing is unrevealing. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 5, 2024 Category: General Medicine Source Type: research

Breaking Barriers: Current Advances and Future Directions in Mpox Therapy
CONCLUSION: In this summary, we provide an overview of potential drugs that could be used to treat Mpox and discuss the underlying biological processes of their actions.PMID:38151842 | DOI:10.2174/0113894501281263231218070841 (Source: Current Drug Targets)
Source: Current Drug Targets - December 28, 2023 Category: Drugs & Pharmacology Authors: Bhumi M Shah Palmi Modi Source Type: research

Breaking Barriers: Current Advances and Future Directions in Mpox Therapy
CONCLUSION: In this summary, we provide an overview of potential drugs that could be used to treat Mpox and discuss the underlying biological processes of their actions.PMID:38151842 | DOI:10.2174/0113894501281263231218070841 (Source: Current Drug Targets)
Source: Current Drug Targets - December 28, 2023 Category: Drugs & Pharmacology Authors: Bhumi M Shah Palmi Modi Source Type: research

Effectiveness of two same-manufacturer intravenous immunoglobulin for Kawasaki disease
CONCLUSIONS: Compared with brand T, brand P prolonged the fever and hospitalization durations after IVIG treatment and increased the proportion of IVIG treatment unresponsiveness, but it did not infer the coronary arteries sequelae.PMID:38097428 | DOI:10.1016/j.jfma.2023.11.014 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 14, 2023 Category: General Medicine Authors: Kun-Lang Wu Ming-Tai Lin Yu-Jun Chang Source Type: research

Effectiveness of two same-manufacturer intravenous immunoglobulin for Kawasaki disease
CONCLUSIONS: Compared with brand T, brand P prolonged the fever and hospitalization durations after IVIG treatment and increased the proportion of IVIG treatment unresponsiveness, but it did not infer the coronary arteries sequelae.PMID:38097428 | DOI:10.1016/j.jfma.2023.11.014 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - December 14, 2023 Category: General Medicine Authors: Kun-Lang Wu Ming-Tai Lin Yu-Jun Chang Source Type: research