Primary Immunodeficiency Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Immunological Evaluation of Pediatric Patients with Polyautoimmunity
CONCLUSION: The occurrence of early onset polyautoimmunity in association with severe and/or recurrent infections or in patients with a positive family history should be a warning sign for physicians to initiate an evaluation for possible immunodeficiency disorders to prevent complications through early treatment.PMID:37702233 | DOI:10.2174/1871530323666230912124951 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 13, 2023 Category: Endocrinology Authors: Fatemeh Sadat Mahdavi Marzieh Tavakol Fatemeh Aghamahdi Homa Sadri Zahra Chavoshzadeh Mahnaz Jamee Shahab Noorian Mohammad Reza Alaei Pooya Ashkevari Juan-Manuel Anaya Hassan Abolhassani Hans D Ochs Gholamreza Azizi Source Type: research

Immunological Evaluation of Pediatric Patients with Polyautoimmunity
CONCLUSION: The occurrence of early onset polyautoimmunity in association with severe and/or recurrent infections or in patients with a positive family history should be a warning sign for physicians to initiate an evaluation for possible immunodeficiency disorders to prevent complications through early treatment.PMID:37702233 | DOI:10.2174/1871530323666230912124951 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 13, 2023 Category: Drugs & Pharmacology Authors: Fatemeh Sadat Mahdavi Marzieh Tavakol Fatemeh Aghamahdi Homa Sadri Zahra Chavoshzadeh Mahnaz Jamee Shahab Noorian Mohammad Reza Alaei Pooya Ashkevari Juan-Manuel Anaya Hassan Abolhassani Hans D Ochs Gholamreza Azizi Source Type: research

Mycosis fungoides as an exclusive manifestation of common variable immunodeficiency in a family with a NFKB2 gene mutation
Conclusions: This case highlights the importance of high-throughput sequencing techniques for the proper diagnosis and treatment of hereditary hematological disorders. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - September 13, 2023 Category: Cancer & Oncology Source Type: research

Rare solid tumors in a patient with Wiskott –Aldrich syndrome after hematopoietic stem cell transplantation: case report and review of literature
ConclusionHere, we describe the case of a patient with WAS who developed two rare solid tumors after HSCT. An active surveillance program for the risk of tumors is necessary in the long-term follow-up of post-HSCT WAS patients. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - September 13, 2023 Category: Allergy & Immunology Source Type: research

Case Report: Mycosis fungoides as an exclusive manifestation of common variable immunodeficiency in a family with a NFKB2 gene mutation
ConclusionThis case highlights the importance of high-throughput sequencing techniques for the proper diagnosis and treatment of hereditary hematological disorders. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - September 13, 2023 Category: Cancer & Oncology Source Type: research

The Experiences of Children with Primary Immunodeficiency Who Receive Immunoglobulin Subcutaneously Instead of Intravenously
Children with primary immunodeficiency disorder have begun receiving subcutaneous immunoglobulin (SCIg) instead of intravenous immunoglobulin (IVIg). So, we aim to explore the experiences of primary immunodeficiency children with regard to receiving SCIg instead of IVIg. (Source: Journal of Pediatric Health Care)
Source: Journal of Pediatric Health Care - September 11, 2023 Category: Pediatrics Authors: Semra K öse, Raheleh Sabetsarvestani, Emine Geçkil, Elanur Kaleci, Hatice Dönmez Tags: Article Source Type: research

Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer
Cardiovasc Toxicol. 2023 Sep 8. doi: 10.1007/s12012-023-09806-5. Online ahead of print.ABSTRACTBased on a few studies, heart failure patients with breast cancer were assessed to find potential biomarkers for doxorubicin-induced cardiotoxicity. However, key immune-related transcriptional markers linked to doxorubicin-induced cardiotoxicity in breast cancer patients have not been thoroughly investigated. We used GSE40447, GSE76314, and TCGA BRCA cohorts to perform this study. Then, we performed various bioinformatics approaches to identify the key immune-related transcriptional markers and their association with doxorubicin-...
Source: Cardiovascular Toxicology - September 8, 2023 Category: Cardiology Authors: Daiqin Xiong Jianhua Yang Dongfeng Li Jie Wang Source Type: research

Clinical and immunological characterisation of patients with common variable immunodeficiency related immune thrombocytopenia
AbstractPrimary Immune thrombocytopenia (ITP) is an autoimmune disease. Secondary ITP occurs in patients with underlying diseases such as common variable immunodeficiency (CVID). CVID is one of the most common symptomatic primary immunodeficiencies in adults, characterised by infectious and non-infectious symptoms. Amongst CVID patients, ITP is the most frequent autoimmune manifestation. In this single-centre study, we performed a clinical and immunological characterisation of 20 patients with CVID-related ITP and 20 ITP patients without CVID to compare severity and remission rates. We found that patients with CVID-related...
Source: Clinical and Experimental Medicine - September 5, 2023 Category: Research Source Type: research

Other iatrogenic immunodeficiency ‐associated lymphoproliferative disorders in anti‐melanoma differentiation‐associated protein 5 associated myositis—Truly iatrogenic or primary immunodeficiency?
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - September 4, 2023 Category: Rheumatology Authors: Chih ‐Wei Tseng, Latika Gupta Tags: EDITORIAL Source Type: research

Punctate inner choroidopathy in common variable immunodeficiency associated with a pathogenic variant in the tumour necrosis factor receptor superfamily 13b (TNFRSF13B) gene - Case report and review of the literature
CONCLUSION: Autoimmunity may be the dominant clinical presenting feature of CVID. Punctuate inner choroidopathy is an idiopathic inflammatory chorioretinopathy, and to the best of our knowledge, has not been previously reported in CVID. A better understanding of the molecular bases of autoimmune diseases in CVID may provide novel therapeutic targets for autoimmune diseases in this patient population.PMID:37652172 | DOI:10.1016/j.clim.2023.109748 (Source: Clinical Immunology)
Source: Clinical Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Hiba Mohammed Hussein Salih Kelvin Cheng Kah Wai Justin McKee Charu Chopra Source Type: research