Primary Immunodeficiency Disease Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Combined Malonic and Methylmalonic Aciduria Diagnosed by Recurrent and Severe Infections Mimicking a Primary Immunodeficiency Disease: A Case Report
J Korean Med Sci. 2023 Nov 20;38(45):e387. doi: 10.3346/jkms.2023.38.e387.ABSTRACTCombined malonic and methylmalonic aciduria is a rare genetic disorder caused by ACSF3 biallelic variants that results in impaired protein and fat metabolism and the accumulation of malonic and methylmalonic acids. A 52-day-old infant with a fever and a history of possible meningitis during the neonatal period was hospitalized. Multiple lesions of necrotizing lymphadenitis with abscesses in the left inguinal area were treated by incision and drainage along with appropriate antibiotic therapy, which revealed a methicillin-resistant Staphylococ...
Source: J Korean Med Sci - November 21, 2023 Category: General Medicine Authors: Joon Kee Lee Arum Oh Source Type: research

Secondary hypogammaglobulinemia in adults-A large retrospective cohort study
CONCLUSION: SHG was associated with more than one etiological factor and a high frequency of infections. IgG-RT indication was irregular yet still effective. It is relevant to consider IgG levels screening, monitoring and accurate indication of IgG-RT.PMID:37980212 | DOI:10.1016/j.medcli.2023.10.005 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - November 18, 2023 Category: Cancer & Oncology Authors: Ernestina Angarola Ver ónica Andrea Peuchot Fernando Warley Diana In és Liberatore Source Type: research

Secondary hypogammaglobulinemia in adults-A large retrospective cohort study
CONCLUSION: SHG was associated with more than one etiological factor and a high frequency of infections. IgG-RT indication was irregular yet still effective. It is relevant to consider IgG levels screening, monitoring and accurate indication of IgG-RT.PMID:37980212 | DOI:10.1016/j.medcli.2023.10.005 (Source: Medicina Clinica)
Source: Medicina Clinica - November 18, 2023 Category: General Medicine Authors: Ernestina Angarola Ver ónica Andrea Peuchot Fernando Warley Diana In és Liberatore Source Type: research

Molecular markers that predict response to combined radiotherapy and immunotherapy in patients with lung adenocarcinoma: a bioinformatics analysis
CONCLUSIONS: In patients with LUAD, TLR8 and CCR5 expression are potential markers of a favorable response to combined immunotherapy and RT.PMID:37969379 | PMC:PMC10643968 | DOI:10.21037/tcr-23-968 (Source: Cell Research)
Source: Cell Research - November 16, 2023 Category: Cytology Authors: Lu Sun Haiting Zhou Cheng Wu Yi Peng Source Type: research

Longevity of the humoral and cellular responses after SARS-CoV-2 booster vaccinations in immunocompromised patients
AbstractWe assessed the humoral and cellular immune responses after two booster mRNA vaccine administrations [BNT162b2 (Pfizer-BioNTech vaccine)] in cohorts of immunocompromised patients (n = 199) and healthy controls (HC) (n = 54). All patients living with HIV (PLWH) and chronic kidney disease (CKD) patients and almost all (98.2%) of the primary immunodeficiency (PID) patients had measurable antibodies 3 and 6 months after administration of the third and fourth vaccine dose, comparable to the HCs. In contrast, onl y 53.3% and 83.3% of the multiple sclerosis (MS) and rheumatologic patients, respectively, developed...
Source: European Journal of Clinical Microbiology and Infectious Diseases - November 13, 2023 Category: Microbiology Source Type: research

Dosing Strategy of Immunoglobulin (IgG) Replacement Therapies in Obese and Overweight Patients with Primary Immunodeficiency Diseases (PIDDs): A Meta-Analysis of Clinical Trials
J Clin Pharmacol. 2023 Nov;63 Suppl 2:S110-S116. doi: 10.1002/jcph.2368.ABSTRACTThe current dosing strategy of immune globulin products for the treatment of primary immunodeficiency diseases (PIDDs) in the USA is based on total body weight (BW). The aim of our study was to assess the relationship between dose and trough level, and to determine whether an alternative dosing strategy should be considered for patients who are overweight or obese. We analyzed data in a total of 533 patients from 11 studies. We modeled the relationship between trough level and dose per week using a linear mixed model. We used an over-dispersed ...
Source: The Journal of Clinical Pharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: Tingting Zhou Million A Tegenge Basil Golding John Scott Source Type: research

Evaluation of Psychiatric Symptomatology, Quality of Life, and Caregiver Burden in Mothers and Children with Primary Immunodeficiency
CONCLUSION: Statistically, we found significantly lower psychosocial health summary scores and total scale score levels from the subclass of PedsQL in the patient group than in the control group. According to the views of both children and mothers, we observed that PID children had higher depression and anxiety scores than healthy children. It was also found that the BDI and BAI values in case of mothers in the patient group were significantly higher than those in the control group.PMID:37937495 | DOI:10.15586/aei.v51i6.927 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 8, 2023 Category: Allergy & Immunology Authors: N ülüfer Kılıç Şuheda Kaya G ülay Taşçı Filiz Özsoy Mehmet K ılıç Source Type: research