GSE218219 Transcriptomic investigation of the modes of action of polymyxins and colistin/sulbactam combination against carbapenem-resistant Acinetobacter baumannii
Contributors : Xingchen Bian ; Mengyao Li ; Xiaofen Liu ; Yan Zhu ; Jian Li ; Phillip J Bergen ; Wanzhen Li ; Xin Li ; Meiqing Feng ; Jing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiCarbapenem-resistant Acinetobacter baumannii (CRAB) is a Priority 1 (Critical) pathogen urgently requiring new antibiotics. Polymyxins are a last-line option against CRAB-associated infections. This transcriptomic study utilized a CRAB strain to investigate mechanisms of bacterial killing with polymyxin B, colistin, colistin B and colistin/sulbactam combination therapy. After ...
Source: GEO: Gene Expression Omnibus - July 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Acinetobacter baumannii Source Type: research
Metabolomics revealed mechanism for the synergistic effect of sulbactam, polymyxin-B and amikacin combination against Acinetobacter baumannii
ConclusionThe metabolomic analysis identified mechanisms responsible for the synergistic activities of polymyxin-B/amikacin/sulbactam against MDR A. baumannii. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - June 29, 2023 Category: Microbiology Source Type: research
The Efficacy and Influencing Factors of Polymyxin B in High-Level Carbapenem-Resistant Klebsiella pneumoniae Infections
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - June 27, 2023 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation
In conclusion, these results suggest that baicalein decreases p53 acetylation level by elevating SIRT1, which can then inhibit PMB-induced ferroptosis and ultimately attenuates AKI.PMID:37354967 | DOI:10.1016/j.cbi.2023.110607 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - June 24, 2023 Category: Molecular Biology Authors: Meiling Yu Hongyu Li Boying Wang Zhenxiang Wu Sheng Wu Guojun Jiang Huaxue Wang Yingying Huang Source Type: research
Case Report: A case of spinal muscular atrophy with extensively drug-resistant Acinetobacter baumannii pneumonia treated with nebulization combined with intravenous polymyxin B: experience and a literature review
Spinal muscular atrophy (SMA) is a neurodegenerative disease that results in progressive and symmetric muscle weakness and atrophy of the proximal limbs and trunk due to degeneration of spinal alpha-motor neurons. Children are classified into types 1–3, from severe to mild, according to the time of onset and motor ability. Children with type 1 are the most severe, are unable to sit independently, and experience a series of respiratory problems, such as hypoventilation, reduced cough, and sputum congestion. Respiratory failure is easily complicated by respiratory infections and is a major cause of death in children with S...
Source: Frontiers in cellular and infection microbiology - June 21, 2023 Category: Microbiology Source Type: research
Polymyxin B complexation enhances the antimicrobial potential of graphene oxide
In this study, antimicrobial peptide polymyxin B (PMB) was adsorbed onto the surface of pristine GO and GO functionalized with triethylene glycol.MethodsThe antibacterial effects of the resulting materials were examined by evaluating minimum inhibitory concentration, minimum bactericidal concentration, time kill assay, live/dead viability staining and scanning electron microscopy.Results and discussionPMB adsorption significantly enhanced the bacteriostatic and bactericidal activity of GO against both planktonic cells and bacterial cells in biofilms. Furthermore, the coatings of PMB-adsorbed GO applied to catheter tubes st...
Source: Frontiers in cellular and infection microbiology - June 21, 2023 Category: Microbiology Source Type: research
Targeted therapy using polymyxin B hemadsorption in patients with sepsis: a post-hoc analysis of the JSEPTIC-DIC study and the EUPHRATES trial
Polymyxin B hemadsorption (PMX-HA) reduces blood endotoxin levels, but characteristics of patients with sepsis likely to benefit from PMX-HA are not well known. We sought to identify patient subgroups likely t... (Source: Critical Care)
Source: Critical Care - June 21, 2023 Category: Intensive Care Authors: Itsuki Osawa, Tadahiro Goto, Daisuke Kudo, Mineji Hayakawa, Kazuma Yamakawa, Shigeki Kushimoto, Debra M. Foster, John A. Kellum and Kent Doi Tags: Research Source Type: research
The VxrAB two-component system is important for the polymyxin B-dependent activation of the type VI secretion system in Vibrio cholerae O1 strain A1552
Canadian Journal of Microbiology, Ahead of Print. The type VI secretion system (T6SS) is used by bacteria for virulence, resistance to grazing, and competition with other bacteria. We previously demonstrated that the role of the T6SS in interbacterial competition and in resistance to grazing is enhanced in Vibrio cholerae in the presence of subinhibitory concentrations of polymyxin B. Here, we performed a global quantitative proteomic analysis and a targeted transcriptomic analysis of the T6SS-known regulators in V. cholerae grown with and without polymyxin B. The proteome of V. cholerae is greatly modified by polymyxin B ...
Source: Canadian Journal of Microbiology - June 21, 2023 Category: Microbiology Authors: Annabelle Mathieu-Denoncourt Marylise Duperthuy Source Type: research
Polymyxin B therapy based on therapeutic drug monitoring in carbapenem-resistant organisms sepsis: the PMB-CROS randomized clinical trial
The appropriate administration regimen of polymyxin B is yet controversial. The present study aimed to explore the optimal dose of polymyxin B under therapeutic drug monitoring (TDM) guidance. (Source: Critical Care)
Source: Critical Care - June 13, 2023 Category: Intensive Care Authors: Shaohua Liu, Ying Wu, Shaoyan Qi, Huanzhang Shao, Min Feng, Lihua Xing, Hongmei Liu, Yanqiu Gao, Zhiqiang Zhu, Shuguang Zhang, Yuming Du, Yibin Lu, Jing Yang, Pingyan Chen and Tongwen Sun Tags: Research Source Type: research
Coexistence of blaIMP-4, blaNDM-1 and blaOXA-1 in blaKPC-2-producing Citrobacter freundii of clinical origin in China
ConclusionWe found C. freundii carrying blaIMP–4, blaNDM–1, blaOXA-1, and blaKPC-2 for the first time, and conducted in-depth research on its drug resistance mechanism, molecular transfer mechanism and epidemiology. In particular, we found that blaIMP-4, blaOXA-1, and blaNDM-1 coexisted on a new transferable hybrid plasmid that carried many drug resistance genes and insertion sequences. The plasmid may capture more resistance genes, raising our concern about the emergence of new resistance strains. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - June 12, 2023 Category: Microbiology Source Type: research
Anticoagulation Prophylaxis in Extracorporeal Adsorption Techniques
Contrib Nephrol. 2023 Jun 1;200:1-6. doi: 10.1159/000527572. Online ahead of print.ABSTRACTIn this chapter, anticoagulation treatments for adsorption techniques in continuous renal replacement therapy (CKRT) will be reviewed. Anticoagulation used with adsorption techniques is quite different than anticoagulation in classical CKRT with nonadsorptive therapies. Regional citrate anticoagulation (RCA) and unfractionated heparin (UFH) are the most common anticoagulation modalities for both nonselective adsorptive membranes - such as surface-treated acrylonitrile 69 membranes (AN69ST) and polymethylmethacrylate membranes - and s...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: Patrick M Honore Sydney Blackman Ibrahim Bousbiat Emily Perri ëns Rachid Attou Source Type: research
Adsorption of Endotoxin and Mitigation of Sepsis
Contrib Nephrol. 2023 Jun 1;200:1-9. doi: 10.1159/000527708. Online ahead of print.ABSTRACTIn the fields of sepsis and systemic inflammation, endotoxin might be the most studied molecule since the term was coined by Richard Pfeiffer in 1892. Paradoxically measuring endotoxin in humans and finding an effective treatment for endotoxemia have remained challenging. While advances have been made in understanding the mechanisms of how this simple molecule can trigger an intense immune cascade, there is an ever growing need to develop better treatments. Studies measuring endotoxin levels in patients with septic shock have consist...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: John A Kellum Hisataka Shoji Debra M Foster Paul M Walker Source Type: research
Hemoperfusion: Indications, Dose, Prescription
Contrib Nephrol. 2023 Jun 1;200:1-10. doi: 10.1159/000529294. Online ahead of print.ABSTRACTRecent advances in the development of sorbent materials have enabled the development of hemoperfusion (HP). However, HP dose and prescription are not standardized and there is no consensus in clinical practice guidelines. Adequate prescription and modality are of utmost importance to ensure HP effectiveness. Although the main indication of CytoSorb®, HA330/380, polymyxin B, and Seraph® is sepsis, these devices may be beneficial in many other situations such as liver failure, rhabdomyolysis, pancreatitis, cardiopulmonary bypass, ex...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: Frank Bidar Stanislas Abrard Antoine Lamblin Thomas Rimmel é Source Type: research
Anticoagulation Prophylaxis in Extracorporeal Adsorption Techniques
Contrib Nephrol. 2023 Jun 1;200:1-6. doi: 10.1159/000527572. Online ahead of print.ABSTRACTIn this chapter, anticoagulation treatments for adsorption techniques in continuous renal replacement therapy (CKRT) will be reviewed. Anticoagulation used with adsorption techniques is quite different than anticoagulation in classical CKRT with nonadsorptive therapies. Regional citrate anticoagulation (RCA) and unfractionated heparin (UFH) are the most common anticoagulation modalities for both nonselective adsorptive membranes - such as surface-treated acrylonitrile 69 membranes (AN69ST) and polymethylmethacrylate membranes - and s...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: Patrick M Honore Sydney Blackman Ibrahim Bousbiat Emily Perri ëns Rachid Attou Source Type: research
Adsorption of Endotoxin and Mitigation of Sepsis
Contrib Nephrol. 2023 Jun 1;200:1-9. doi: 10.1159/000527708. Online ahead of print.ABSTRACTIn the fields of sepsis and systemic inflammation, endotoxin might be the most studied molecule since the term was coined by Richard Pfeiffer in 1892. Paradoxically measuring endotoxin in humans and finding an effective treatment for endotoxemia have remained challenging. While advances have been made in understanding the mechanisms of how this simple molecule can trigger an intense immune cascade, there is an ever growing need to develop better treatments. Studies measuring endotoxin levels in patients with septic shock have consist...
Source: Contributions to Nephrology - June 1, 2023 Category: Urology & Nephrology Authors: John A Kellum Hisataka Shoji Debra M Foster Paul M Walker Source Type: research
