Sounds in Silence: How the Cochlea Promotes Refinement of Auditory Circuits before Hearing Onset
NIH Neuroscience Seminar Series
Robert Wenthold Memorial Lecture
Dr. Bergles lab is interested in understanding the mechanisms by which neurons and glial cells interact to support normal communication in the nervous system. Neurons transmit information at specialized synaptic junctions, points of contact where action potentials elicit the release of a chemical neurotransmitter. Neurotransmission at excitatory synapses involves the vesicular release of glutamate, diffusion and binding of glutamate to various receptors, and uptake of glutamate by transporters. Transporters are critical for ensuring that receptors are availab...
Source: Videocast - All Events - April 26, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Opiates on the brain
NIH Director's Wednesday Afternoon Lecture Series
Dr. Kieffer is a basic scientist and neurobiologist. She isolated the first gene encoding an opioid receptor, a landmark in neuroscience research to understanding molecular bases of opioid transmission and opioid-mediated mechanisms underlying pain control, mood disorders and addiction. Her team elucidated the role of each opioid receptor in both known and unknown areas of opioid physiology and behaviors using gene knockout in mice. She showed that mu receptors mediate both analgesic and addictive actions of morphine, and are responsible for drug and social reward. Her team...
Source: Videocast - All Events - April 24, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
The Science of Interoception and Its Roles in Nervous System Disorders (Day 2)
The objectives of this workshop are to identify gaps in research related to the science of interoception, its role(s) in nervous system disorders, and to develop strategies and recommendations to facilitate the advancement of this area of research. The workshop will bring together expertise from diverse fields including basic neuroscience, psychology, physiology, and clinical research to deliberate two important dynamic connections – the connections between brain and body and the connections between basic research and human/clinical research. The primary focus areas for the workshop include: the neural circuitry underlyi...
Source: Videocast - All Events - March 19, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
The Science of Interoception and Its Roles in Nervous System Disorders (Day 1)
The objectives of this workshop are to identify gaps in research related to the science of interoception, its role(s) in nervous system disorders, and to develop strategies and recommendations to facilitate the advancement of this area of research. The workshop will bring together expertise from diverse fields including basic neuroscience, psychology, physiology, and clinical research to deliberate two important dynamic connections – the connections between brain and body and the connections between basic research and human/clinical research. The primary focus areas for the workshop include- the neural circuitry underlyi...
Source: Videocast - All Events - March 19, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Everything you wanted to know about microtubules but were afraid to ask
NIH Director's Seminar Series
Dr. Roll-Mecak will discuss the research of the Laboratory of Cell Biology and Biophysics Section, NINDS. The title of her talk is " Everything you wanted to know about microtubules but were afraid to ask " .
In addition to providing structural support, microtubules form a complex and dynamic intracellular " highway " that delivers molecular cargo from one end of the cell to another - which in the case of neuronal cells can span several feet. Given the continually changing cell physiology, this delivery system undergoes constant remodeling as cargo is transported to different destinations with...
Source: Videocast - All Events - January 31, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Natural products and Pain: The Search for Novel Nonopioid Analgesics
Discussion will focus on how to identify promising leads based on traditional medicine; discover and identify active natural products; and characterize the mechanisms through which they act.
The workshop is chaired by David Julius, Ph.D., professor and chair of the physiology department at the University of California-San Francisco School of Medicine. Dr. Julius is an expert of international renown on the molecular biology of how signals are received and transmitted by the nervous system, including in touch and pain.Air date: 2/6/2019 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - January 28, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Maurice B. Burg Lecture: Insights into Human Hypertension and Renal Physiology from Human Genetics and Genomics
Maurice B. Burg Lecture 2018: Insights into Human Hypertension and Renal Physiology from Human Genetics and Genomics by Dr. Richard P. Lifton MD, PhD of Rockefeller UniversityAir date: 10/29/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 26, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Genes controlling sleep and circadian rhythms
NIH Director ’ s Wednesday Afternoon Lecture Series
The Young lab studies 24-hour circadian clocks, which time the recurring, daily activities observed in most organisms. These cellular clocks are active in most animal tissues and establish daily rhythms in physiology and behavior. The lab ’ s findings have implications for sleep and mood disorders as well as for dysfunctions related to the timing of gene activities underlying visual functions, locomotion, metabolism, immunity, learning, and memory.For more information go tohttps://oir.nih.gov/walsAir date: 10/17/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 26, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Special CCR Grand Rounds: 1) Pooled CRISPR Screens for Cancer Biology and 2) Dietary control of intestinal stem cells in physiology and disease
Special CCR Grand Rounds – 2018 AAAS Martin and Rose Wachtel Cancer Research Award and Lecture
The Wachtel Cancer Research Award is presented to young cancer researchers who have made outstanding contributions to the cancer field.
This is the sixth lecture for the AAAS Martin and Rose Wachtel Cancer Research Award sponsored by the American Association for the Advancement of Science(AAAS) and Science Translational Medicine. The National Cancer Institute (NCI) Center for Cancer Research (CCR) is co-hosting the event.Air date: 8/10/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 6, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Mitochondria control of physiology and disease: beyond ATP
NIH Director ’ s Wednesday Afternoon Lecture Series
For decades, the mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles generating metabolites for the production of macromolecules and ATP, respectively. Our work has elucidated that mitochondria have a third distinct role whereby they release reactive oxygen species (ROS) and metabolites such as L-2-hydroxyglutarate to initiate physiological and pathological processes including hypoxic activation of HIFs, cellular differentiation, T cell activation and cancer cell proliferation. Thus, mitochondria function as signaling organelles.For more ...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Comb jellies hold keys to deep-sea animal adaptations (Image 5)
A team of divers returns from the second collection dive of the day. Scientists from several institutions converged during a research cruise to study many aspects of ctenophore and gelatinous plankton biology, ecology, physiology and genomics. [Image 5 of 6 related images. See (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - November 28, 2017 Category: Science Source Type: video
The Human Microbiome: Emerging Themes at the Horizon of the 21st Century (Day 3)
The 2017 NIH-wide microbiome workshop will strive to cover advances that reveal the specific ways in which the microbiota influences the physiology of the host, both in a healthy and in a diseased state and how the microbiota may be manipulated, either at the community, population, organismal or molecular level, to maintain and/or improve the health of the host. The goal will be to seek input from a trans-disciplinary group of scientists to identify 1) knowledge gaps, 2) technical hurdles, 3) new approaches and 4) research opportunities that will inform the development of novel prevention and treatment strategies based on ...
Source: Videocast - All Events - July 17, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The Human Microbiome: Emerging Themes at the Horizon of the 21st Century (Day 1)
The 2017 NIH-wide microbiome workshop will strive to cover advances that reveal the specific ways in which the microbiota influences the physiology of the host, both in a healthy and in a diseased state and how the microbiota may be manipulated, either at the community, population, organismal or molecular level, to maintain and/or improve the health of the host. The goal will be to seek input from a trans-disciplinary group of scientists to identify 1) knowledge gaps, 2) technical hurdles, 3) new approaches and 4) research opportunities that will inform the development of novel prevention and treatment strategies based on ...
Source: Videocast - All Events - July 17, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The Human Microbiome: Emerging Themes at the Horizon of the 21st Century (Day 2)
The 2017 NIH-wide microbiome workshop will strive to cover advances that reveal the specific ways in which the microbiota influences the physiology of the host, both in a healthy and in a diseased state and how the microbiota may be manipulated, either at the community, population, organismal or molecular level, to maintain and/or improve the health of the host. The goal will be to seek input from a trans-disciplinary group of scientists to identify 1) knowledge gaps, 2) technical hurdles, 3) new approaches and 4) research opportunities that will inform the development of novel prevention and treatment strategies based on ...
Source: Videocast - All Events - July 17, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Epithelial molecules shaping immunosurveillance by local T cells
Immunology Interest Group Seminar Series
The thesis of conventional immunology is centralized control whereby responses to infection within tissues are decided within lymph nodes, from which effector T lymphocytes are dispatched to quell regional disturbances. But this cannot explain the observation that many tissues at steady state are T cell-rich. Do such cells simply provide responses to infection or do they provide more generalized means to sustain tissue integrity and organ function? Likewise, how are such cells able to respond to acute stress but not drive constitutive tissue inflammation? And, how do immune cell –...
Source: Videocast - All Events - May 8, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
