Pfizer Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Respiratory Syncytial Virus Vaccination in Older Adults: Considerations for Use and Shared Clinical Decision-Making
CONCLUSION: The introduction of RSVpreF3 and RSVpreF vaccines represents a significant advancement in the management of RSV in older adults. This article underscores the importance of shared clinical decision-making in vaccine administration and the effective coordination of an interprofessional team for coadministration with other vaccines. [Journal of Gerontological Nursing, 50(3), 7-12.].PMID:38417072 | DOI:10.3928/00989134-20240207-02 (Source: Journal of Gerontological Nursing)
Source: Journal of Gerontological Nursing - February 28, 2024 Category: Nursing Authors: Morgan A Gerber Michael K Burke Michael R Brodeur Source Type: research

Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents
mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted the need to better understand the interaction of adjuvants and the early innate immune response. Type I interferon (IFN-I) is an integral part of this early innate response that primes several components of the adaptive immune response. Women are widely reported to respond better than men to tri- and quadrivalent influenza vaccines. Plasmacytoid dendritic cells (pDCs) are the primary cell type responsible for IFN-I production, and female pDCs produce more IFN-I than male pDCs since the upstream pattern recognition receptor Toll-like rec...
Source: Frontiers in Immunology - February 28, 2024 Category: Allergy & Immunology Source Type: research

Anosmia or Ageusia Following COVID-19 Vaccination: A Systematic Review
Conclusion: Anosmia and ageusia are important symptoms of COVID-19 vaccination. These symptoms will resolve without any treatment in most cases, although some interventions may be needed in some patients.PMID:38411125 | DOI:10.1177/01455613241233098 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - February 27, 2024 Category: ENT & OMF Authors: Razman Arabzadeh Bahri Fatemeh Esmaeilpur Abianeh Maral Peisepar Reihaneh Hadi Fatemeh A Basti Saba Maleki Hanieh Radkhah Source Type: research

Duplication of a chromosome 2 segment in production CHO cell lines correlates with age-related growth improvement
In this study, we investigated the molecular mechanisms underlying the age-correlated cell growth improvement in Pfizer's platform fed-batch production process, by examining multiple cell lines derived from different CHO expression systems, expressing a variety of monoclonal antibodies (mAbs). Comprehensive whole-genome resequencing analysis revealed duplication of a continuous 50.2 Mbp segment in chromosome 2 (Chr2) specific to clones that showed age-correlated growth change as compared to clones that did not exhibit age-correlated growth change. Moreover, such age- and growth-related Chr2 duplication was independent of t...
Source: Biotechnology Journal - February 25, 2024 Category: Biotechnology Authors: Wei Wei Laura Zielewicz Lin Zhang Source Type: research

Administration of the GSK Respiratory Syncytial Virus Vaccine to Pregnant Persons in Error
Obstet Gynecol. 2024 Feb 23. doi: 10.1097/AOG.0000000000005551. Online ahead of print.ABSTRACTThe GSK and Pfizer respiratory syncytial virus (RSV) vaccines are both indicated for adults aged 60 years and older, but only the Pfizer product is approved for use in pregnancy to prevent RSV-associated lower respiratory tract disease in infants aged younger than 6 months. To assess for vaccine administration errors (ie, administration of the GSK RSV vaccine to pregnant persons) VAERS (Vaccine Adverse Event Reporting System), a U.S. passive reporting system, was searched for the time period from August 2023 to January 2024. A tot...
Source: Obstetrics and Gynecology - February 23, 2024 Category: OBGYN Authors: Pedro L Moro Ruth Gallego Anne Scheffey Katherine E Fleming-Dutra Elisha Hall Bicheng Zhang Paige Marquez Jefferson M Jones Narayan Nair Karen R Broder Source Type: research