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Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Atherosclerosis Leading to Peripheral Artery Disease Impacts Muscle Function via Reduced Blood Flow
Researchers working on a new way to assess the progression of peripheral artery disease here note how this consequence of atherosclerosis harms function of muscles via reduced blood flow. Reduced blood flow is in fact something of a theme in aging, as the heart weakens, physical activity is reduced, capillary density in tissues declines, and atherosclerotic lesions grow to the point of narrowing critical arteries. This is all good reason to find approaches to minimize and treat atherosclerosis, develop strategies to provoke greater angiogenesis in later life to better maintain capillary networks, and stay active. ...
Source: Fight Aging! - October 3, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Bonus Features – October 2, 2022 – Tech vendors commit to standardizing SDoH data at White House event, 1 in 3 patients using telehealth to manage a chronic condition, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News Last week’s White House Conference on Hunger, Nutrition, and Health pledged to take action to reduce hunger and diseases related to poor diets in areas such as food access, healthy food choices, physician activity, an...
Source: EMR and HIPAA - October 2, 2022 Category: Information Technology Authors: Brian Eastwood Tags: Health IT Company Healthcare IT Telemedicine and Remote Monitoring ACEP AGS Health Andrew Hine athenahealth Avel eCare Babylon Boston Scientific BrightInsight Brightwork Health IT Butterfly Network Clearsense CliniShift CRISP Source Type: blogs

Periodontal disease linked to heart failure – New study report
Periodontal disease linked to heart failure – New study report Periodontal disease is known to be associated with coronary artery disease as well as poses a risk for bacteremia and subsequent risks [1]. A recent report looked at 6707 participants of the ARIC (Atherosclerosis Risk In Communities) study who had full-mouth periodontal examination at visit 4 between 1996-1998 and longitudinal follow up for incident heart failure. Data on incident heart failure was checked from visit 4 to 2018. In addition data on incident heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fract...
Source: Cardiophile MD - September 25, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Posterior leads can give false reassurance
A 40-something woman with diabetes and peripheral vascular disease who frequently needs the ED for chronic pain called 911 for sudden severe chest pain. The patient was very agitated and could not hold still.I greeted medics at the door to view the prehospital ECG.Here it is:It is not normal, but there is no specific evidence of Occlusion MI (OMI)There are some Q-waves in inferior and lateral leads (of uncertain age) and there is some " terminal QRS distortion " in inferior leads and V4-V6, but this finding may be present normally in these leads (it is NOT normal in lead V2/V3 in the presence of normal variant ST ele...
Source: Dr. Smith's ECG Blog - September 21, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs

Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

More Mitochondrial Fission Improves Mitophagy, Mitochondrial Function, and Angiogenesis
Mitochondria are essential cell components that become dysfunctional with age, a cause of a significant fraction of age-related degeneration. These organelles are descended from ancient symbiotic bacteria, and the herd of mitochondria in a cell is dynamic, fusing together, splitting apart, and passing around component parts. As mitochondria become worn and damaged, they are removed by the quality control process of mitophagy. This all works well in youth. In the context of aging, a fair amount of evidence points to impaired mitochondrial fission as an important contributing cause of impaired mitophagy, which in turn...
Source: Fight Aging! - April 12, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Cracking Calcium in Arteries Using Sound Waves: Interview with Shockwave Medical ’s Scott Shadiow
Shockwave Medical, a medtech company based in California, has developed a technique called intravascular lithotripsy, which involves delivering sonic waves to calcified plaque in an artery in much the same way that sound waves have been used to treat kidney stones for many years. The idea is to safely crack the calcified deposits so that a stent can then be inserted to open the artery. At present, calcified coronary arteries are typically treated using high pressure balloons, which can sometimes struggle to disrupt calcified deposits and the high pressure involved can pose safety issues. Other techniques include using s...
Source: Medgadget - August 26, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Radiology Vascular Surgery Source Type: blogs

P2-CHA2DS2-VASc Score
P2-CHA2DS2-VASc score adds additional two points to the CHA2DS2-VASc score for an abnormal P wave axis to predict risk of stroke in atrial fibrillation (AF) [1]. The seminal study was an attempt to identify utility of P wave indices in sinus rhythm to predict the risk of stroke over and above the existing CHA2DS2-VASc score. P wave indices evaluated were prolonged P wave duration, abnormal P wave axis, advanced interatrial block and abnormal P wave terminal force in lead V1. They found that abnormal P wave axis which is an ECG correlate of left atrial abnormality improves the prediction of ischemic stroke. They concluded ...
Source: Cardiophile MD - July 21, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

The Road to Low Cost Universal Cells and Tissues, For Transplantation into Any Patient
An area of intense interest in the academic and biotechnology communities is the development of cells that do not provoke an immune response due to mismatch of cell surface receptors. As a general rule, cells from one individual are rejected by any other individual. It is possible to minimize this outcome by eliminating MHC receptors, but there are other complex interactions between cell surface chemistry and portions of the immune system that can still act as a barrier to transplantation. A number of groups have developed approaches to address specific parts of this problem space, but no one winner has yet emerged. At the...
Source: Fight Aging! - July 20, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A woman with near-syncope, bradycardia, and hypotension
Written by Pendell MeyersA 59-year-old woman with diabetes, hypertension, prior stroke, and peripheral vascular disease presented with multiple near-syncopal events over the past 2 days, as well as ongoing back pain. EMS found her bradycardic in the 40s and administered atropine with no response. She was mentating and had a reasonable blood pressure (around 90s systolic), so they decided not to pace prehospital. On arrival the patients blood pressure was 79/50 mm Hg. She was still awake and alert. Here is her first ECG (no baseline available):What do you think?Findings: - junctional bradycardia (no P waves,...
Source: Dr. Smith's ECG Blog - December 18, 2020 Category: Cardiology Authors: Pendell Source Type: blogs

Better heart health in eight weeks? Double down on fruits and veggies
Two decades ago, the DASH (Dietary Approaches to Stop Hypertension) study tested the effects of three different diets on almost 500 participants over eight weeks. The first diet was a typical American diet, relatively low in fruits and vegetables (3.5 servings daily) and high in junk foods and sweets. The second offered more fruits and vegetables (8.5 servings daily) as well as seeds, nuts, and beans, and not many sweets. The third was the very healthy DASH diet, rich in fruits and vegetables (9.5 servings daily), beans, nuts, seeds, and whole grains, and barely any sweets. Participants truly stuck to each diet plan: All m...
Source: Harvard Health Blog - June 11, 2020 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Diet and Weight Loss Food as medicine Health Heart Health Nutrition Source Type: blogs

Fight Aging! Newsletter, May 11th 2020
In this study, we found that older nematodes have higher ROS levels. Interestingly, after hydrogen treatment, the ROS levels were significantly decreased, and hydrogen could significantly extend the lifespans of the N2, sod-3 and sod-5 mutant strains, by approximately 22.7%, 9.5%, and 8.7%, respectively. In addition, aging is regulated by a variety of pathways, such as the insulin signaling pathway, the rapamycin target signaling pathway, and the caloric restriction pathway. However, our results showed that the lifespans of the daf-2 and daf-16 strains, in which these pathways are upregulated, were not affected afte...
Source: Fight Aging! - May 10, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Improving Transplanted Stem Cell Function via Tethered Signal Molecules
The field of biotechnology is churns with inventive technology demonstrations; this is an era of creativity, unleashed by a rapid advance in knowledge and capabilities. Here, researchers are presented with the challenge of achieving sustained beneficial activation of transplanted stem cells, where culturing the cells with activating signal molecules prior to transplantation produces only a transient effect. They solve the problem by tethering the signal molecules to the stem cell surfaces; the transplanted cells will continue to be stimulated by this signal for as long as they survive. Like all of the best ideas, it is ent...
Source: Fight Aging! - May 7, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Pain and neuromodulation: What ’s all the “buzz” about?
Chronic pain is an enigma for both pain doctors and their patients: difficult to understand (as everyone’s pain is different), challenging to treat effectively, and frustrating to live with. Desperate patients sometimes turn to drastic and irreversible surgical procedures, like amputating nerves to relieve pain, and unfortunately even those procedures may fail to provide the hoped-for results. Fortunately there have been great strides in research related to pain perception and our nervous system’s reaction to various pain treatments, and we’ve been able to develop novel devices that provide many people with much-need...
Source: Harvard Health Blog - March 3, 2020 Category: Consumer Health News Authors: Shafik Boyaji, MD Tags: Back Pain Pain Management Source Type: blogs