Peripheral Vascular Disease (PVD) Blogs This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Familial hypercholesterolemia – recent advances
Familial hypercholesterolemia is a genetic disorder, the chromosomal locus of which has been mapped to chromosome No. 19. It is an autosomal dominant disorder and should be suspected when the total cholesterol levels are above 300 mg/dL in adults and above 250 mg/dL in children. Those who are homozygous for the gene have very high cholesterol values and have atherosclerotic disorders very early in life with potential for significantly reduced survival (less than 30 years). In addition to tuberous and tendon xanthomas, they have corneal arcus, features of coronary, cerebral or peripheral vascular disease and aortic stenosis...
Source: Cardiophile MD - July 16, 2014 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology Anti Sense Oligo-nucleotide hypercholesterolemia LDL apheresis Microsomal Triglyceride transfer protein inhibitor Mipomersen PCSK9 PCSK9 inhibitor monoclonal antibodies PCSK9 inhibitors Proprotein convertase subtilisin Source Type: blogs

MKSAP: 64-year-old man with knee osteoarthritis
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 64-year-old man is evaluated for a 2-year history of knee osteoarthritis. He has bilateral knee pain that worsens with walking. He has tried topical therapies, physical therapy, and acetaminophen, none of which has provided relief. The patient also has peripheral vascular disease, hyperlipidemia, and hypertension. Medications are hydrochlorothiazide, pravastatin, and a daily aspirin. On physical examination, temperature is 37.0 °C (98.6 °F), blood pressure is 116/76 mm Hg, pulse rate is 60/min, and respirati...
Source: Kevin, M.D. - Medical Weblog - July 12, 2014 Category: Journals (General) Authors: mksap Tags: Meds Rheumatology Source Type: blogs

A Stressing Situation
A 64-year-old woman presented to the emergency department with two days of severe nausea, numerous episodes of vomiting, and progressively worsening right upper quadrant/epigastric abdominal pain. She was continuously spitting clear secretions into an emesis bag on arrival in triage. Her 8/10 dull ”ripping” pain originated in the right upper quadrant and radiated in a band-like pattern to her epigastrium. She was not experiencing any chest pain or shortness of breath. Her medical history included hypertension, type 2 diabetes mellitus, recurrent acute pancreatitis secondary to hyperglycemia, peripheral artery disease, ...
Source: Spontaneous Circulation - March 10, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

The Mediterranean Diet and Peripheral Artery Disease
While several studies have shown that eating a Mediterranean diet can reduce the risk of heart attack and stroke, until now there has been no evidence from clinical trials that it can also help to prevent peripheral artery disease (PAD)....Read Full Post (Source: About.com Heart Disease)
Source: About.com Heart Disease - January 22, 2014 Category: Cardiology Source Type: blogs

Top stories in health and medicine, November 21, 2013
From MedPage Today: New Method Gives Better Guess on LDL Cholesterol. A new way of estimating LDL cholesterol levels may be more accurate than the widely used Friedewald equation. Novel Anticoagulant Bests Warfarin in Afib. The novel oral factor Xa inhibitor edoxaban prevented stroke as well as warfarin but did so with lower risk in nonvalvular atrial fibrillation. Mixed Data for Warfarin Dosing By Genotype. For patients requiring anticoagulation for atrial fibrillation, venous thromboembolism, or some other indication, genotype-guided dosing of warfarin and similar drugs might have some benefit. Procedure Plus Exercise ...
Source: Kevin, M.D. - Medical Weblog - November 21, 2013 Category: Family Physicians Tags: News Heart Source Type: blogs

Peripheral Artery Disease (PAD)
In peripheral artery disease (PAD), one or more of the arteries supplying blood to the legs or arms becomes blocked or partially blocked, usually because of atherosclerosis. Patients with PAD often experience significant pain when using the affected limb - a condition called "claudication" - and if the PAD is severe, ulcers or gangrene can result. Read here about PAD, its causes, its symptoms, and what you can do about it. (Source: About.com Heart Disease)
Source: About.com Heart Disease - September 6, 2013 Category: Cardiology Source Type: blogs

COPD’s friendly handshake with CAD !
Human biology has always been a mystery and can express in a dramatic way . While , many disorders combine to play havoc on the body , few tend to protect each other. HT and DM can join a deadly coalition to attack the heart . Smoking causes extensive peripheral vascular disease , still thrombo angitis of coronary arteries ( due to smoking ) is virtually unknown. Tuberculosis does not have the courage to attack the heart valves , while it can inflict serious injuries all over the body . Similarly , systemic hypertension and Rheumatic heart disease does no...
Source: Dr.S.Venkatesan MD - August 31, 2013 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized COPD and CAD does copd has a protective effect on CAD Source Type: blogs

COPD’s friendly handshake with CAD !
In this mean world ,most truths exist without evidence . . . and often falsehoods masquerade as truths with overwhelming evidence ! Human biology has always been a mystery and can express in dramatic ways . While , many disorders combine to play havoc on the body , few tend to protect each other. HT and DM can join a deadly coalition to attack the heart .Smoking causes extensive peripheral vascular disease , still thrombo angitis of coronary arteries ( due to smoking ) is virtually unknown. Tuberculosis does not have the courage to attack the heart valves , w...
Source: Dr.S.Venkatesan MD - August 31, 2013 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized COPD and CAD does copd has a protective effect on CAD Source Type: blogs

The NIH's Drug Repurposing Program Gets Going
Here's an update on the NIH's NCATS program to repurpose failed clinical candidates from the drug industry. I wrote about this effort here last year, and expressed some skepticism. It's not that I think that trying drugs (or near-drugs) for other purposes is a bad idea prima facie, because it isn't. I just wonder about the way the way the NIH is talking about this, versus its chances for success. As was pointed out last time this topic came up, the number of failed clinical candidates involved in this effort is dwarfed by the number of approved compounds that could also be repurposed - and have, in fact, been looked at fo...
Source: In the Pipeline - July 22, 2013 Category: Chemists Tags: Clinical Trials Source Type: blogs

On The Pulse - 12th July 2013
Treating peripheral vascular disease (Source: OnMedica Blogs)
Source: OnMedica Blogs - July 13, 2013 Category: Health Medicine and Bioethics Commentators Source Type: blogs

Vascular Plumbing: A Visit to Mt. Sinai’s Cath Lab in Manhattan (w/video)
Dr. Prakash Krishnan snaking a catheter through the femoral artery to the site of the occlusion while wearing a ZeroGravity suit and using a Siemens fluoroscope. Minimally invasive interventions have opened a whole new way to treat a variety of cardiac and vascular conditions that were otherwise risky and required a great deal of traditional surgical work. The change is so drastic that cath labs look and feel different, and are often operated separately, from the rest of interventional cardiology, radiology and vascular surgery departments. There are no scalpels, very little blood, clinicians are wearing lead-lined suits, ...
Source: Medgadget - July 2, 2013 Category: Technology Consultants Authors: Gene Ostrovsky Tags: Cardiac Surgery Cardiology Medgadget Exclusive Vascular Surgery Source Type: blogs

The Obesity of Americans--and Nurses
It appears that the American Medical Association has decided to designate obesity as a disease. So, if one in three Americans is now classified as being obese, does that mean that one in three nurses is obese as well?Research shows that the causes of obesity are multifactorial, so it seems to make sense to reclassify it so that insurance companies will presumably pay for treatment and prevention more readily. I would hope that this move by the AMA pays off in terms of available treatment--as well as even more increased attention to what amounts to a crisis of public health.We've now firmly established that obesity rates ...
Source: Digital Doorway - June 20, 2013 Category: Nurses Tags: nurse wellness nursing nurses nurse self care public health obesity prevention Source Type: blogs

Exercise Versus Peripheral Artery Disease
Some age-related conditions are greatly impacted by exercise, and a sedentary lifestyle is one of the factors raising the risk of suffering these conditions. Type 2 diabetes is the best known of these, a lifestyle disease that you can actually exercise and diet your way out of if you work at it hard enough. Peripheral artery disease isn't so escapable, being a later stage in the process of deterioration, but exercise is still beneficial to a point comparable to other options for treatment: Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow capacity to the legs of patients. PAD leads to ...
Source: Fight Aging! - May 31, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Daily News Source Type: blogs

Diabetes and your feet
The following is a guest post: If you or anyone you know suffers from diabetes, you are well aware of the damage the body endures. When there is too much glucose in the bloodstream for a long period of time, diabetes problems are sure to arise. The high blood glucose (blood sugar) will damage many and often times multiple parts of the body; heart, blood vessels, eyes, kidneys, and even feet. There are two main problems that are caused from too much glucose in your blood to focus on which will cause harm to your feet; nerve damage and poor blood flow. With damaged nerves in your legs and feet, one may not be able to feel...
Source: Medicine and Technology by Dr. Joseph Kim - April 19, 2013 Category: Technology Consultants Tags: guest post Source Type: blogs