Peripheral Vascular Disease (PVD) Blogs This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Injectable Scaffolding Gel Improves Regeneration of Blood Vessels and Muscle Tissue
Researchers have demonstrated that introducing a gel scaffold material of the type used in tissue engineering into living tissues can improve the ability to regenerate at some forms of injury and compensate for some forms of age-related degeneration. Here they test this approach on peripheral artery disease, in which narrowing of major blood vessels due to atherosclerosis means insufficient oxygen and nutrients are delivered to tissues. This causes a wide range of dysfunction, leading eventually to critical limb ischemia and amputation or worse. Spurring tissue regrowth and remodeling via the introduction of scaffolding ma...
Source: Fight Aging! - March 9, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Gene Therapy to Treat Peripheral Artery Disease
Peripheral artery disease is a narrowing of blood vessels in the limbs, usually caused by the progression of atherosclerosis, and consequent failure to deliver enough oxygen to cells. Tissues fail to heal and grow, and ultimately die, causing serious medical conditions along the way. Here researchers are trying a more sophisticated form of patch therapy, not addressing the root causes, but altering the signals delivered to cells in order to create greater growth and regrowth in blood vessels. This has the potential to partially compensate for the progression of blood vessel narrowing, but like all compensatory approaches i...
Source: Fight Aging! - January 29, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Ghrelin as a Treatment for Peripheral Artery Disease
Ghrelin is secreted in the body as a part of the process of hunger, and increased amounts in circulation have a range of sweeping effects on the operation of metabolism. It has been proposed that some portion of the long-term health benefits of calorie restriction and intermittent fasting arise because there are longer periods of hunger and thus longer periods in which there is more circulating ghrelin. For example, ghrelin has been shown to reduce inflammation and promote the development of new immune cells, among many other changes. So read this research in the broader context; I note it because it should be of interest ...
Source: Fight Aging! - December 17, 2015 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Peripheral Intra Arterial Thrombolysis
Cannulate the vessel and pass a guidewire across the thrombus before thrombolysis. Heparin is given intravenously as soon as the guide wire passes the thrombus. Heparin bolus of 70 units per / kg followed by infusion of 1000 units / hour (maintain APTT 1.5 to 2.5 times control). Catheter with multiple side holes used for thrombolysis. Streptokinase is not generally used in view of bleeding complications. Either Urokinase or tPA (tissue type plasminogen activator) is used. Immediate success 60-90%. 2 year patency upto 80%. Complications of peripheral intra arterial thrombolysis Most common complication: 3 -20% site bleed. I...
Source: Cardiophile MD - December 5, 2015 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Angiography and Interventions Peripheral Vascular Disease Intra Arterial Thrombolysis Intracranial bleeds myocardial infarction tissue type plasminogen activator tPA Urokinase Source Type: blogs

Absent radial pulse in ICU setting
What possibilities are to be considered when a radial pulse is absent in a patient in the ICU: a) Aberrant radial artery – look for the aberrant artery pulsation in the ‘anatomical snuff box’ on the lateral aspect of the wrist near the base of the first metacarpal. b) Occluded radial artery due to previous trauma, aortoarteritis, embolic occlusion or peripheral vascular disease c) Dissection of ascending aorta compromising the ostium of subclavian artery d) Automatic inflation of non invasive blood pressure cuff occurring at the time of examination. Though it is a transient phenomenon, it can fool you so...
Source: Cardiophile MD - October 16, 2015 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology Source Type: blogs

Praluent, the Next Expensive "Game Changer," Blockbuster," "New Hope," - But Not Yet Shown to Benefit Patients
ConclusionsThe NEJM study was accompanied by an editorial by Stone and Lloyd-Jones(2) which documented that drugs previously shown to lower cholesterol were never proved to do any good for patients, and concluded,it would be premature to endorse these drugs for widespread use before the ongoing randomized trials, appropriately powered for primary end-point analysis and safety assessment, are available. After an FDA advisory committee recommended approval of aliromucab and another PCSK9 inhibitor in June, 2015, John Mandrola entitled a Medscape article,Dear FDA: Resist the Urge on PCSK9 DrugsHis reasons included lack o...
Source: Health Care Renewal - August 5, 2015 Category: Health Management Tags: aliromucab evidence-based medicine health care prices manipulating clinical research PCSK9 inhibitor Praluent Regeneron Sanofi-Aventis Source Type: blogs

Targeting physician salaries: I speak for the ten-percenters
I’m a cardiologist. But if you believe the news, you will assume my entire medical specialty is shady and full of morally suspect physicians. Let me tell you why. Recently, two articles surfaced in the lay press, one published by the New York Times and the other by U.S. News & World Report. Like the majority of medical news that I’ve seen originate from these sources over the last few years, the articles provide no meaningful contribution to advancing quality standards in medicine or improving patient care. They are written by medical outsiders and fraught with errors. But, to their defense, the authors hav...
Source: Kevin, M.D. - Medical Weblog - March 14, 2015 Category: Journals (General) Authors: Rocky Bilhartz, MD Tags: Policy Primary care Source Type: blogs

MKSAP: 74-year-old man with fever and chills
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 74-year-old man is evaluated in the emergency department for a 3-day history of fever and chills as well as confusion. He has a 5-week history of a nonhealing ulcer on the plantar surface of his left foot. He has diabetes mellitus, hypertension, and peripheral vascular disease for which he takes metformin, glyburide, lisinopril, chlorthalidone, and aspirin. He has no known medication allergies. On physical examination, temperature is 39.0 °C (102.2 °F), blood pressure is 92/60 mm Hg, pulse rate is 108/min, a...
Source: Kevin, M.D. - Medical Weblog - January 17, 2015 Category: Journals (General) Authors: mksap Tags: Conditions Diabetes Infectious disease Source Type: blogs

New Treatment for Peripheral Artery Disease is Approved by the FDA
It was 51 years ago that Charles Dotter first opened a blockage in the superficial femoral artery using catheters. He invented angioplasty, coined the term, and began a revolution, but it wasn't until recently that the dream of a non-surgical durable way of treating peripheral artery disease came to fruition. With the Lutonix approved last October and Medtronic's IN.PACT drug-coated balloon approved yesterday, a new era has begun. (Source: Burts Stent Blog : The Voice in the Ear)
Source: Burts Stent Blog : The Voice in the Ear - January 7, 2015 Category: Medical Equipment Source Type: blogs

FDA Approves New Medtronic Drug-Coated Balloon To Open Blocked Leg Arteries
Medtronic said today that it had received approval from the FDA to market its In.Pact Admiral drug-coated balloon (DCB) to treat peripheral artery disease (PAD) in the upper leg. The device is the second DCB to gain FDA approval. Last October the FDA approved CR Bard’s Lutonix DCB for a similar indication. … Click here to read the full post on Forbes. (Source: CardioBrief)
Source: CardioBrief - January 5, 2015 Category: Cardiology Authors: Larry Husten Tags: Interventional Cardiology & Surgery Policy & Ethics drug-coated balloons Medtronic PAD peripheral arterial disease Source Type: blogs

First Drug-Coated Balloon Approved By FDA For Leg Blockages
The FDA today announced that it had approved for use in the US the first drug-coated angioplasty balloon catheter to re-open blocked arteries in the thigh and knee (superficial femoral and popliteal arteries). The Lutonix 035 Drug Coated Balloon Percutaneous Transluminal Angioplasty Catheter (Lutonix DCB) is manufactured by CR Bard and has been available in Europe since 2012. … Click here to read the full post on Forbes. (Source: CardioBrief)
Source: CardioBrief - October 10, 2014 Category: Cardiology Authors: Larry Husten Tags: Interventional Cardiology & Surgery People, Places & Events Policy & Ethics CR Bard FDA Lutonix PAD peripheral artery disease Source Type: blogs

Advancing Innovation To Eliminate Health Disparities
TweetThe advent of population health management, community-based care coordination, and mobile health technologies provide a promising opportunity to address longstanding and persistent health disparities. Separately each adds a new dimension to research and analysis, and to individual and community-level public health prevention and access to quality care. Together, providers, payers and researchers alike can acquire a richer understanding of contextual, environmental, and behavioral factors that contribute to disparate outcomes in health. Existing innovations in data capture, epidemiologic profiling, clinical translation...
Source: Health Affairs Blog - September 4, 2014 Category: Health Management Authors: Joseph West Tags: All Categories Chronic Care Disparities Nonmedical Determinants Research Source Type: blogs

Wheat: the silent killer
I’ll hear this comment with some frequency: “Go wheat-free for 4 weeks. If you feel no better, you can go back to it.” While consumption of modern wheat can indeed yield health conditions with overt symptoms, such as joint pain, skin rashes, and pain and explosive diarrhea from irritable bowel syndrome, many of its effects are silent and do not result in any perceived symptoms. The changes that underlie autoimmunity, for instance, that lead to multiple sclerosis, Hashimoto’s thyroiditis, rheumatoid arthritis, autoimmune hepatitis, autoimmune pancreatitis, pancreatic beta cell destruction leading t...
Source: Wheat Belly Blog - August 15, 2014 Category: Cardiology Authors: Dr. Davis Tags: News & Updates autoimmunity blood sugar cancer gluten Inflammation wheat Source Type: blogs

May-Thurner syndrome (Iliac vein compression syndrome)
May-Thurner syndrome denotes iliac vein compression by the crossing iliac artery at the iliocaval junction. Usually it is the left iliac vein which is compressed by the right iliac artery. The compression increases the risk of deep vein thrombosis. Other names for the syndrome are iliac vein compression syndrome and Cockett syndrome. The obstruction may cause varicosities in the affected limb and ulcers due to chronic venous stasis. The pulsations of the overlying artery causes intimal hypertrophy of the vein which adds to the severity of the obstruction. Some reports show that deep vein thrombosis occurs three to eight ti...
Source: Cardiophile MD - July 27, 2014 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: Angiography and Interventions Peripheral Interventions Peripheral Vascular Disease chronic venous stasis Cockett syndrome iliac vein compression by the crossing iliac artery iliac vein compression syndrome left iliac vein compressed by right Source Type: blogs