Fight Aging! Newsletter, September 21st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Pediatric Fertility Preservation for Hormone Suppression in Transgender Youth
Last week, I received an e-mail update on current research and treatment being performed at the institution where I did my residency training. One of the interesting research areas was in the discipline of pediatric fertility preservation. Pediatric patients who undergo cancer treatments often take medications which cause destruction of their testicles or ovaries, not … Continue reading "Pediatric Fertility Preservation for Hormone Suppression in Transgender Youth" (Source: blog.bioethics.net)
Source: blog.bioethics.net - September 1, 2020 Category: Medical Ethics Authors: Mark McQuain Tags: Health Care bioethics biotechnology human dignity reproduction syndicated Source Type: blogs
Fight Aging! Newsletter, August 10th 2020
This study aimed to characterize the role of BDNF in age-related microglial activation. Initially, we found that degrees of microglial activation were especially evident in the substantia nigra (SN) across different brain regions of aged mice. The levels of BDNF and TrkB in microglia decreased with age and negatively correlated with their activation statuses in mice during aging. Interestingly, aging-related microglial activation could be reversed by chronic, subcutaneous perfusion of BDNF. Peripheral lipopolysaccharide (LPS) injection-induced microglial activation could be reduced by local supplement of BDNF, while shTrkB...
Source: Fight Aging! - August 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 29th 2020
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks.
Sedentary Behavior Raises the Risk of Cancer Mortality
https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/
Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a r...
Source: Fight Aging! - June 28, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescence-Associated Secretory Phenotype Proteins as a Biomarker of Aging
In today's open access research, the authors report on the generation of a biomarker of aging from the study of proteins secreted by senescent cells. Low cost assays that map closely to biological age, the burden of damage, are a potentially useful tool for research and development of rejuvenation therapies. This biomarker is likely not general enough for that role; the accumulation of senescent cells with age in tissues throughout the body is just one of a number of mechanisms important in degenerative aging. It is always good to have further evidence that senescent cells are important in aging, to add to the very compell...
Source: Fight Aging! - June 26, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
New drugs approved for advanced BRCA-positive prostate cancer
Defective BRCA genes are well known for their ability to cause breast and ovarian cancers in women. But these same gene defects are also strong risk factors for aggressive prostate cancer in men. About 10% of men with metastatic prostate cancer — meaning cancer that is spreading away from the prostate — test positive for genetic mutations in BRCA genes. Fortunately, these cancers can be treated with new types of personalized therapies.
In May, the FDA approved two new drugs specifically for men with BRCA-positive metastatic prostate cancer that has stopped responding to other treatments. One of the drugs, called rucapa...
Source: Harvard Health Blog - June 15, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Prostate Knowledge Treatments HPK Source Type: blogs
Chemotherapy and hearing loss: Monitoring is essential
Treatment for cancer is a difficult time for patients and their families. While there are significant benefits of chemotherapy in treating and managing many types of cancers, some of the negative side effects may not always be so obvious. One of the potential negative effects of chemotherapy that you may not be aware of is hearing loss. Hearing loss caused by chemotherapy is generally considered a type of sudden hearing loss, so monitoring hearing before and after treatment with hearing tests is important.
How are chemotherapy and hearing loss connected?
Hearing loss as a potential side effect of chemotherapy is more likel...
Source: Harvard Health Blog - April 13, 2020 Category: Consumer Health News Authors: James Naples, MD Tags: Cancer Ear, nose, and throat Hearing Loss Source Type: blogs
Fight Aging! Newsletter, March 16th 2020
We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site.
Age-Related Epigenetic Changes that Suppress Mitochondrial Function
https://www.fightaging.org/archives/2020/03/age-related-epigenetic-changes-that-suppress-mitochondrial-function/
Today's open access research reports on two specific epigenetic changes observed in old individuals that act to reduce mitochondrial function. This joins an existing list of genes for which expression changes are known to impact mitochondrial function with age. A herd of hundreds of mitochondria are found...
Source: Fight Aging! - March 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Novel Reprogramming Approach Applied to Generation of Cells for Retinal Regeneration
Researchers here report on the application of a novel form of cellular reprogramming that might be more useful than the present standard approach when it comes to generating patient-matched cells and tissues for regenerative medicine. They demonstrate this via the creation of vascular progenitor cells that might be used to treat some forms of retinal degeneration in which blood vessels in that tissue have atrophied.
Scientists began their experiments with a fibroblast - a connective tissue cell - taken from a person with type 1 diabetes. Reprogrammed fibroblasts function as stem cells, with the potential to give r...
Source: Fight Aging! - March 13, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
My Infertility Journey as a Woman in Medicine
Editor’s Note: For more on the challenges as well as strategies to address physician infertility, please read this Academic Medicine Invited Commentary, cowritten by the author of this blog post.
Most of us in medicine pride ourselves on being organized, detail-oriented, conscientious and able to achieve excellent results with enough hard work—and are not used to failure and loss of control. My experience with infertility has been the first time that I truly experienced failure and complete loss of control, realizing that fertility is not a merit-based system. No matter how hard I try, how many doctors I cons...
Source: Academic Medicine Blog - March 11, 2020 Category: Universities & Medical Training Authors: Guest Author Tags: Featured Guest Perspective infertility physician well-being women in academic medicine Source Type: blogs
Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MR1 as a Broad Signature of Cancer, Suitable for T Cell Targeting
Meaningful progress towards the control of cancer, ending it as a major threat to life and health, will be led by programs that can produce very broadly applicable treatments. That means therapies that can be applied to many (or even all) cancers with minimal differences in configuration or need for further per-cancer development. There are hundreds of cancer subtypes, but only so many researchers, and only so much funding for research and development: development of highly specific therapies is just not an effective path forward.
Examples of the most promising lines of work with broad application include the OncoSe...
Source: Fight Aging! - January 22, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Researchers urge prostate cancer screening for men with BRCA gene defects
Prostate cancer screening with the prostate-specific antigen (PSA) test has been criticized for flagging too many slow-growing tumors that might never be life-threatening.
But some men have inherited gene defects that boost their risk of developing prostate cancers that can be quite aggressive. Is PSA screening particularly well-suited for these genetically defined groups? New research suggests the answer is yes.
In November, a team of British scientists released highly anticipated findings from a study of PSA screening in men with defects in a pair of important genes called BRCA1 and BRCA2. Better known for increasing the...
Source: Harvard Health Blog - December 20, 2019 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Prostate Knowledge Screening HPK Source Type: blogs
Fight Aging! Newsletter, December 16th 2019
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - December 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Large Study of Aspirin Use Finds Reduced Mortality, Contradicting the Recent ASPREE Study Results
The back and forth over whether regular aspirin use is beneficial continues with the publication of results from analysis of a large patient population that show a 15% reduction in all cause mortality in patients using aspirin. This contradicts the much smaller (but still large in and of itself) ASPREE clinical trial, in which patients using aspirin exhibited a small increase in mortality in comparison to their peers. As in that earlier study, the data here strongly suggests that benefits and risks vary with patient characteristics, such as whether or not a patient is overweight.
Aspirin is thought to be a weak calo...
Source: Fight Aging! - December 13, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
