Gameto Raises $20M at an Early Stage to Focus on Ovarian Aging
One of the signs of investor enthusiasm for an industry is the existence of projects that raise significant funding at a very early stage of their development. We're seeing that happen for cellular reprogramming, but companies started by well-connected individuals in other parts of the longevity industry are now raising a great deal of funding in early preclinical stages of development. This suggests that we will continue to see a growing influx of capital into the development of ways to treat aging as a medical condition, pulling more research projects out of the constraints of academia and into an environment of greater ...
Source: Fight Aging! - January 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Granulosa Cell Tumour: CT
Granulosa cell tumours on are typically slow-growing, predominantly solid masses with variable amounts of cystic change and intratumoral hemorrhage. Oestrogenic effects on the uterus may manifest as uterine enlargement or as endometrial thickening or carcinoma. GCT is distinct from other ovarian carcinomas in their hormonal activity; their ability to secrete estrogen, inhibin, and M üllerian inhibiting substance.Famous Radiology Blog http://www.sumerdoc.blogspot.com
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Source: Sumer's Radiology Site - September 22, 2021 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Breast Cancer Screening: We Can Do Better
The three risk assessment tools now in use fall far short. Using the latest deep learning techniques, investigators are developing more personalized ways to locate women at high risk.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.The promise of personalized medicine will eventually allow clinicians to offer individual patients more precise advice on prevention, early detection and treatment. Of course, the operative word iseventually.A closer examination of the screening tools available to detect breast c...
Source: Life as a Healthcare CIO - August 31, 2021 Category: Information Technology Source Type: blogs
Can some postmenopausal women with breast cancer skip chemotherapy?
Breast cancer remains the most common cancer among women. In the last two decades, the treatment of breast cancers has become personalized. This has been possible due to the subtyping of breast cancers. Breast cancers have been subtyped based on the receptors on the breast cancer cell. The most clinically significant receptors — those that have targeted therapies — are the estrogen and progesterone receptors and the human epidermal growth factor receptor 2 (HER2). Cancers that have the estrogen and progesterone receptors are termed hormone receptor (HR)-positive cancers.
The development of hormone therapy for HR-positi...
Source: Harvard Health Blog - April 15, 2021 Category: Consumer Health News Authors: Salewa T. Salewa Oseni, MD Tags: Cancer Medical Research Women's Health Source Type: blogs
Accelerating the Development of Tests for Endometriosis and Cancer
NIGMS’ Small Business Technology Transfer (STTR) program works toward more effective methods for patient screening, diagnosis, and treatment.
Translating lab discoveries into health care products requires large investments of time and resources. Through the STTR Regional Technology Transfer Accelerator Hubs for IDeA States program, NIGMS helps researchers interested in transitioning their discoveries and/or inventions into products. Here are the stories of three researchers working with the XLerator Hub, which funds projects in the southeastern United States and Puerto Rico.
Ending Diagnostic Delays for Endomet...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 7, 2021 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness Cancer Diseases Profiles Scientific Process Source Type: blogs
Top 10 Hazards Of Technology In Digital Health
Thanks to the advent of digital health, the future of medicine is truly exciting. With technological advancements that democratise access to care, better treatments are accessible to people than ever before. Breakthrough research and medical developments have eradicated deadly diseases and turned others into manageable conditions. But the very developments that propel healthcare to the 21st century bring their own share of hazards to the field.
From the elimination of privacy through hacked medical devices to bioterrorism, there are signs of alarming trends that few take seriously. Nevertheless, we must generate discussion...
Source: The Medical Futurist - March 30, 2021 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Bioethics Biotechnology Digital Health Research Healthcare Policy Nanotechnology Security & Privacy Telemedicine & Smartphones algorithm ecg google smartwatch wearables GC1 wannacry ransomw Source Type: blogs
TOP 10 Dangers Of Digital Health
Thanks to the advent of digital health, the future of medicine is truly exciting. With technological advancements that democratise access to care, better treatments are accessible to people than ever before. Breakthrough research and medical developments have eradicated deadly diseases and turned others into manageable conditions. But the very developments that propel healthcare to the 21st century bring their own share of hazards to the field.
From the elimination of privacy through hacked medical devices to bioterrorism, there are signs of alarming trends that few take seriously. Nevertheless, we must generate discussion...
Source: The Medical Futurist - March 30, 2021 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Bioethics Biotechnology Digital Health Research Healthcare Policy Nanotechnology Security & Privacy Telemedicine & Smartphones algorithm ecg google smartwatch wearables GC1 wannacry ransomw Source Type: blogs
Dieneke
A few days ago I discovered that my blog reader/friend Dieneke Ferguson had died months ago, in October. She had been diagnosed with MM in her 50s for which she had undergone many conventional treatments. When she was left with no options (but the final one!!!), many years ago, she came across my blog, got in touch with me, and began taking curcumin, which managed to stabilize her so much so that in 2018 she was interviewed by BBC Radio 4. That interview, if my memory serves me correctly, was picked up by other news agencies. Dieneke became quite well-known.
Unfortunately, she later developed ovarian cancer. The last time ...
Source: Margaret's Corner - February 9, 2021 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs
Do hair dyes increase cancer risk?
This study also had several limitations. First, participants were female nurses of mostly European descent, meaning the findings are not necessarily generalizable to men or to other racial or ethnic groups. Next, the study could not account for every single cancer risk factor (for example, exposure to pesticides and other environmental chemicals). Data were not collected on other hair grooming products beyond hair dyes, and subjects may have mistakenly reported use of permanent hair dyes when they were in fact using semi-permanent or natural dyes. Without data on actual color of hair dyes used, the authors assumed that hai...
Source: Harvard Health Blog - January 20, 2021 Category: Consumer Health News Authors: Shinjita Das, MD Tags: Cancer Skin and Hair Care Source Type: blogs
Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects."
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease
Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Quality of Epigenetic Clocks Continues to Improve
There is at present a diverse exploration of clocks that assess biological age, these clocks constructed as weighted combinations of data picked from the epigenome, transcriptome, or proteome, all of which change in characteristic ways with age. Many different clocks are at various stages of development and refinement. The goal is the production of a robust, low-cost, rapid way to assess the efficacy of potential rejuvenation therapies: if one can use a blood test ten days before and ten days after a treatment, that would be a great deal easier than having to wait and see over the course of a life span.
Unfortunate...
Source: Fight Aging! - December 16, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Aspirin and breast cancer risk: How a wonder drug may become more wonderful
Aspirin has been called a wonder drug. And it’s easy to see why.
It’s inexpensive, its side effects are well-known and generally minor. And since it was developed in the 1890s, it’s been shown to provide a number of potential benefits, such as relieving pain, bringing down a fever, and preventing heart attacks and strokes. Over the last 20 years or so, the list of aspirin’s potential benefits has been growing. And it might be about to get even longer: did you know that aspirin may lower your risk of several types of cancer?
Studies of aspirin and cancer
A number of studies suggest that aspirin can lower the risk of...
Source: Harvard Health Blog - October 23, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Breast Cancer Health Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
