Acute zonal occult outer retinopathy (AZOOR): Case report with confocal scanning laser ophthalmoscopy retromode imaging
J Fr Ophtalmol. 2023 Aug 28:S0181-5512(23)00386-8. doi: 10.1016/j.jfo.2023.08.001. Online ahead of print.NO ABSTRACTPMID:37648550 | DOI:10.1016/j.jfo.2023.08.001 (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - August 30, 2023 Category: Opthalmology Authors: J M Lopez M Rabinovic C J Mehanna G Ricciotti D Colantuono E H Souied Source Type: research
Metabolic changes and retinal remodeling in Heterozygous CRX mutant cats (CRX < sup > RDY/+ < /sup > )
This study investigated retinal remodeling that occurs as photoreceptors degenerate. CRXRdy/+ cats from 6 weeks to 10 years of age were investigated. In vivo structural changes of retinas were analyzed by fundus examination, confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography. Histologic analyses including immunohistochemistry for computational molecular phenotyping with macromolecules and small molecules. Affected cats had a cone-led photoreceptor degeneration starting in the area centralis. Initially there was preservation of inner retinal cells such as bipolar, amacrine and horizontal...
Source: Cell Research - August 25, 2023 Category: Cytology Authors: Laurence M Occelli Bryan W Jones Taylor J Cervantes Simon M Petersen-Jones Source Type: research
Metabolic changes and retinal remodeling in Heterozygous CRX mutant cats (CRX < sup > RDY/+ < /sup > )
This study investigated retinal remodeling that occurs as photoreceptors degenerate. CRXRdy/+ cats from 6 weeks to 10 years of age were investigated. In vivo structural changes of retinas were analyzed by fundus examination, confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography. Histologic analyses including immunohistochemistry for computational molecular phenotyping with macromolecules and small molecules. Affected cats had a cone-led photoreceptor degeneration starting in the area centralis. Initially there was preservation of inner retinal cells such as bipolar, amacrine and horizontal...
Source: Experimental Eye Research - August 25, 2023 Category: Opthalmology Authors: Laurence M Occelli Bryan W Jones Taylor J Cervantes Simon M Petersen-Jones Source Type: research
A novel stop-gain < em > NF1 < /em > variant in neurofibromatosis type 1 and bilateral optic atrophy without optic gliomas
CONCLUSIONS: A patient with NF1 without OPGs developed bilateral optic atrophy and carried a novel de novo stop-gain variant of NF1. Although the relationship between NF1 variants and bilateral optic atrophy remains unclear, further investigations are required.PMID:37599594 | DOI:10.1080/13816810.2023.2245464 (Source: Ophthalmic Genetics)
Source: Ophthalmic Genetics - August 21, 2023 Category: Opthalmology Authors: Naoko Fukunaga Takaaki Hayashi Yuki Yamada Kei Mizobuchi Arihito Ohta Tadashi Nakano Source Type: research
Single-capture ultra-widefield guided swept-source optical coherence tomography in the management of rhegmatogenous retinal detachment and associated peripheral vitreoretinal pathology
Conclusion
Single-capture UWF-SS-OCT enabled novel insights in RRD and associated peripheral vitreoretinal pathology. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - August 21, 2023 Category: Opthalmology Authors: Lee, W. W., Muni, R. H. Tags: Original articles - Clinical science Source Type: research
In Vivo Detection of Retinal Ganglion Cell Stress in Rodents with DARC
Methods Mol Biol. 2023;2708:123-129. doi: 10.1007/978-1-0716-3409-7_13.ABSTRACTDARC (detection of apoptosing retinal cells) uses fluorescently tagged Annexin A5 to identify retinal apoptosis non-invasively in vivo using a confocal laser scanning ophthalmoscope (cSLO). This can provide insights into the presence and progression of disease pathology and the efficacy of neuroprotective intervention. The methods of administration, imaging, and quantification of DARC, including the operation of the cSLO, are described here.PMID:37558966 | DOI:10.1007/978-1-0716-3409-7_13 (Source: Mol Biol Cell)
Source: Mol Biol Cell - August 9, 2023 Category: Molecular Biology Authors: Daniel Hill Soyoung Choi Maria Francesca Cordeiro Source Type: research
Confocal Scanning Laser Ophthalmoscopy to Image Retinal Ganglion Cells in Real-Time
Methods Mol Biol. 2023;2708:115-121. doi: 10.1007/978-1-0716-3409-7_12.ABSTRACTReal-time imaging of retinal ganglion cells (RGCs) provides an opportunity for detailed investigation of retinal development, disease mechanisms, and the evaluation of interventions affecting ocular structures. Here we use a transgenic model to describe a step-by-step protocol for visualizing RGC survival in real-time by using confocal scanning laser ophthalmoscopy (cSLO).PMID:37558965 | DOI:10.1007/978-1-0716-3409-7_12 (Source: Mol Biol Cell)
Source: Mol Biol Cell - August 9, 2023 Category: Molecular Biology Authors: Lili Hao Yuan Liu Xiangxiang Liu Richard K Lee Source Type: research
Confocal Scanning Laser Ophthalmoscopy to Image Retinal Ganglion Cells in Real-Time
Methods Mol Biol. 2023;2708:115-121. doi: 10.1007/978-1-0716-3409-7_12.ABSTRACTReal-time imaging of retinal ganglion cells (RGCs) provides an opportunity for detailed investigation of retinal development, disease mechanisms, and the evaluation of interventions affecting ocular structures. Here we use a transgenic model to describe a step-by-step protocol for visualizing RGC survival in real-time by using confocal scanning laser ophthalmoscopy (cSLO).PMID:37558965 | DOI:10.1007/978-1-0716-3409-7_12 (Source: Molecular Medicine)
Source: Molecular Medicine - August 9, 2023 Category: Molecular Biology Authors: Lili Hao Yuan Liu Xiangxiang Liu Richard K Lee Source Type: research
Evaluation of Uveitis Induced in Rats by a Type I Collagen Peptide as a Model for Childhood Arthritis-associated Uveitis
In this study, we evaluated MAA-induced uveitis in rats as a potential model for JIA-uveitis. We characterizedMAA-induced uveitis by assessing its relationship to age and sex; tracking the occurrence of arthritis, enthesitis, and ANApositivity; and measuring vitreous fluid inflammatory biomarkers. Juvenile and adult and male and female Lewis rats (Rattusnorvegicus) were inoculated with MAA. Slit-lamp biomicroscopy, indirect ophthalmoscopy, and joint examinations wereperformed 3 times weekly. Rats were euthanized at 4 wk after MAA inoculation, and plasma ANA testing, vitreous inflammatorybiomarker assays, and globe histopat...
Source: Comparative Medicine - August 7, 2023 Category: Zoology Authors: Stephanie C Osinchuk Bruce H Grahn Tracy D Wilson Brooke N Thompson David A Hart Kim D Harrison David Ml Cooper Arash Panahifar Alan M Rosenberg Source Type: research
Evaluation of Uveitis Induced in Rats by a Type I Collagen Peptide as a Model for Childhood Arthritis-associated Uveitis
In this study, we evaluated MAA-induced uveitis in rats as a potential model for JIA-uveitis. We characterizedMAA-induced uveitis by assessing its relationship to age and sex; tracking the occurrence of arthritis, enthesitis, and ANApositivity; and measuring vitreous fluid inflammatory biomarkers. Juvenile and adult and male and female Lewis rats (Rattusnorvegicus) were inoculated with MAA. Slit-lamp biomicroscopy, indirect ophthalmoscopy, and joint examinations wereperformed 3 times weekly. Rats were euthanized at 4 wk after MAA inoculation, and plasma ANA testing, vitreous inflammatorybiomarker assays, and globe histopat...
Source: Comparative Medicine - August 7, 2023 Category: Zoology Authors: Stephanie C Osinchuk Bruce H Grahn Tracy D Wilson Brooke N Thompson David A Hart Kim D Harrison David Ml Cooper Arash Panahifar Alan M Rosenberg Source Type: research
Evaluation of Uveitis Induced in Rats by a Type I Collagen Peptide as a Model for Childhood Arthritis-associated Uveitis
In this study, we evaluated MAA-induced uveitis in rats as a potential model for JIA-uveitis. We characterizedMAA-induced uveitis by assessing its relationship to age and sex; tracking the occurrence of arthritis, enthesitis, and ANApositivity; and measuring vitreous fluid inflammatory biomarkers. Juvenile and adult and male and female Lewis rats (Rattusnorvegicus) were inoculated with MAA. Slit-lamp biomicroscopy, indirect ophthalmoscopy, and joint examinations wereperformed 3 times weekly. Rats were euthanized at 4 wk after MAA inoculation, and plasma ANA testing, vitreous inflammatorybiomarker assays, and globe histopat...
Source: Comparative Medicine - August 7, 2023 Category: Zoology Authors: Stephanie C Osinchuk Bruce H Grahn Tracy D Wilson Brooke N Thompson David A Hart Kim D Harrison David Ml Cooper Arash Panahifar Alan M Rosenberg Source Type: research
Evaluation of Uveitis Induced in Rats by a Type I Collagen Peptide as a Model for Childhood Arthritis-associated Uveitis
In this study, we evaluated MAA-induced uveitis in rats as a potential model for JIA-uveitis. We characterizedMAA-induced uveitis by assessing its relationship to age and sex; tracking the occurrence of arthritis, enthesitis, and ANApositivity; and measuring vitreous fluid inflammatory biomarkers. Juvenile and adult and male and female Lewis rats (Rattusnorvegicus) were inoculated with MAA. Slit-lamp biomicroscopy, indirect ophthalmoscopy, and joint examinations wereperformed 3 times weekly. Rats were euthanized at 4 wk after MAA inoculation, and plasma ANA testing, vitreous inflammatorybiomarker assays, and globe histopat...
Source: Comparative Medicine - August 7, 2023 Category: Zoology Authors: Stephanie C Osinchuk Bruce H Grahn Tracy D Wilson Brooke N Thompson David A Hart Kim D Harrison David Ml Cooper Arash Panahifar Alan M Rosenberg Source Type: research
