Renin-angiotensin-aldosterone system inhibitors and mortality risk in elderly patients with atrial fibrillation. Insights from the nationwide START registry
CONCLUSION: A lower mortality risk was found in AF patients on ACE-I/ARBs. Different prescription patterns of antihypertensive drugs between men and women do exist.PMID:37648584 | DOI:10.1016/j.ejim.2023.08.019 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - August 30, 2023 Category: Internal Medicine Authors: Danilo Menichelli Daniela Poli Emilia Antonucci Gualtiero Palareti Pasquale Pignatelli Daniele Pastori START2 Register Investigators Source Type: research
Hordeum vulgare ethanolic extract mitigates high salt-induced cerebellum damage via attenuation of oxidative stress, neuroinflammation, and neurochemical alterations in hypertensive rats
AbstractHigh salt intake increases inflammatory and oxidative stress responses and causes an imbalance of neurotransmitters involved in the pathogenesis of hypertension that is related to the onset of cerebral injury. Using natural compounds that target oxidative stress and neuroinflammation pathways remains a promising approach for treating neurological diseases. Barley (Hordeum vulgare L.) seeds are rich in protein, fiber, minerals, and phenolic compounds, that exhibit potent neuroprotective effects in various neurodegenerative diseases. Therefore, this work aimed to investigate the efficacy of barley ethanolic extract...
Source: Metabolic Brain Disease - August 30, 2023 Category: Neurology Source Type: research
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
We describe comorbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using the literature, a list of pharmacogenes vital in the response to the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred ...
Source: Topics in HIV Medicine - August 25, 2023 Category: Infectious Diseases Authors: Nyarai Desiree Soko Sarudzai Muyambo Michelle T L Dandara Elizabeth Kampira Dirk Blom Erika S W Jones Brian Rayner Delva Shamley Phumla Sinxadi Collet Dandara Source Type: research
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
We describe comorbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using the literature, a list of pharmacogenes vital in the response to the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred ...
Source: Topics in HIV Medicine - August 25, 2023 Category: Infectious Diseases Authors: Nyarai Desiree Soko Sarudzai Muyambo Michelle T L Dandara Elizabeth Kampira Dirk Blom Erika S W Jones Brian Rayner Delva Shamley Phumla Sinxadi Collet Dandara Source Type: research
