Acute High-Output Heart Failure with Pulmonary Hypertension and Severe Liver Injury Caused by Amlodipine Poisoning: A Case Report
We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring showed that while her left ventricular systolic function and cardiac output were elevated, her systemic vascular resistance decreased significantly. At the same time, the size of her right heart, her central venous pressure, and the oxygen saturation of her central venous circulation all increased abnormally. The patient's circulatory function and right ventricular dysfunction gradually improved after large doses of vasopressors and detoxification measures. However, her bilirubin and transaminase levels incr...
Source: Cardiovascular Toxicology - March 26, 2024 Category: Cardiology Authors: Chenlong Wang Qingcheng Zhu Dingyu Tan Joseph Walline Yachao Wang Source Type: research
Design and synthesis of novel dihydropyridine- and benzylideneimine-based tyrosinase inhibitors
Tyrosinase (TYR) inhibitors are very significant as they inhibit enzyme tyrosinase activity, and its inhibition is vital for skin care, anticancer medication, and antibrowning of fruits and vegetables. This work presents a novel and economical route for the preparation of new synthetic tyrosinase inhibitors using amlodipine (4). The novel conjugates 6 (a–o) were designed, synthesized, and characterized by spectroscopic analyses, including Fourier transform infrared and low- and high-resolution mass spectroscopy. The purified compound 4 was refluxed with various aldehydes and ketones 5 (a–o) for 5–8 h in methanol at ...
Source: Frontiers in Pharmacology - March 26, 2024 Category: Drugs & Pharmacology Source Type: research
Carotid Web as a Source of Thromboembolism in a Young African American Female
Conclusion: Our case highlights the clinical relevance of considering carotid web as a potential etiology for ischemic stroke in young, otherwise healthy patients and emphasizes the importance of timely diagnosis and appropriate management to prevent recurrent cerebrovascular events.PMID:38510226 | PMC:PMC10949048 | DOI:10.31486/toj.23.0082 (Source: Ochsner Journal)
Source: Ochsner Journal - March 21, 2024 Category: General Medicine Authors: Eric Assid Chad Hall Mawadah Samad Richard Zweifler Source Type: research
