Amlodipine alleviates renal ischemia/reperfusion injury in rats through Nrf2/Sestrin2/PGC-1 α/TFAM Pathway
Previously, observational studies showed that amlodipine can mitigate calcineurin inhibitor- and contrast-induced acute kidney injury (AKI). Herein, we aimed to measure the effect of amlodipine on renal ischem... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - December 21, 2023 Category: Drugs & Pharmacology Authors: Hadi Shirzad, Seyed Amin Mousavinezhad, Mohammad Panji and Moin Ala Tags: Research Source Type: research
Central ECMO cannulation for severe dihydropyridine calcium channel blocker overdose
We present a case of a 12-year-old with severe dihydropyridine CCB ingestion, refractory to medical management and successfully treated with central ECMO cannulation. The patient was discharged home with no significant disability. Central ECMO cannulation may be helpful to facilitate adequate flows in vasodilatory shock such as CCB overdose.PMID:38099637 | DOI:10.1051/ject/2023037 (Source: Journal of Extra-Corporeal Technology)
Source: Journal of Extra-Corporeal Technology - December 15, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Jose M Cardenas Santiago Borasino Joseph Timpa Jeremy Hawkins Martha McBride William Rushton Jordan Newman Erika Mendoza Robert Sorabella Jonathan Byrnes Source Type: research
Systematic identification and repurposing of FDA-approved drugs as antibacterial agents against Streptococcus pyogenes: In silico and in vitro studies
In this study, 1826 FDA approved drugs have been identified through high-throughput virtual screening. Free Energy Perturbation (FEP) based binding free energy calculations have been performed at the final step of the virtual screening funnel to ensure high accuracy in silico results. Three compounds identified have been tested for susceptibility of S. pyogenes MTCC 442 strain and two antibiotic-resistant clinical isolates of S. pyogenes using microdilution assay. Among the three, two drugs Amlodipine Besylate (Amd) and Ranitidine hydrochloride (Rnt) have shown inhibition against all the tested strains and its mechanism of...
Source: International Journal of Biological Macromolecules - December 15, 2023 Category: Biochemistry Authors: Judith Gracia Damodharan Perumal Prabu Dhandapani Preethi Ragunathan Source Type: research
Central ECMO cannulation for severe dihydropyridine calcium channel blocker overdose
We present a case of a 12-year-old with severe dihydropyridine CCB ingestion, refractory to medical management and successfully treated with central ECMO cannulation. The patient was discharged home with no significant disability. Central ECMO cannulation may be helpful to facilitate adequate flows in vasodilatory shock such as CCB overdose.PMID:38099637 | PMC:PMC10723573 | DOI:10.1051/ject/2023037 (Source: Journal of Extra-Corporeal Technology)
Source: Journal of Extra-Corporeal Technology - December 15, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Jose M Cardenas Santiago Borasino Joseph Timpa Jeremy Hawkins Martha McBride William Rushton Jordan Newman Erika Mendoza Robert Sorabella Jonathan Byrnes Source Type: research
Systematic identification and repurposing of FDA-approved drugs as antibacterial agents against Streptococcus pyogenes: In silico and in vitro studies
In this study, 1826 FDA approved drugs have been identified through high-throughput virtual screening. Free Energy Perturbation (FEP) based binding free energy calculations have been performed at the final step of the virtual screening funnel to ensure high accuracy in silico results. Three compounds identified have been tested for susceptibility of S. pyogenes MTCC 442 strain and two antibiotic-resistant clinical isolates of S. pyogenes using microdilution assay. Among the three, two drugs Amlodipine Besylate (Amd) and Ranitidine hydrochloride (Rnt) have shown inhibition against all the tested strains and its mechanism of...
Source: International Journal of Biological Macromolecules - December 15, 2023 Category: Biochemistry Authors: Judith Gracia Damodharan Perumal Prabu Dhandapani Preethi Ragunathan Source Type: research
Central ECMO cannulation for severe dihydropyridine calcium channel blocker overdose
We present a case of a 12-year-old with severe dihydropyridine CCB ingestion, refractory to medical management and successfully treated with central ECMO cannulation. The patient was discharged home with no significant disability. Central ECMO cannulation may be helpful to facilitate adequate flows in vasodilatory shock such as CCB overdose.PMID:38099637 | PMC:PMC10723573 | DOI:10.1051/ject/2023037 (Source: Journal of Extra-Corporeal Technology)
Source: Journal of Extra-Corporeal Technology - December 15, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Jose M Cardenas Santiago Borasino Joseph Timpa Jeremy Hawkins Martha McBride William Rushton Jordan Newman Erika Mendoza Robert Sorabella Jonathan Byrnes Source Type: research
