Associations of lipids and lipid-lowering drugs with risk of stroke: a Mendelian randomization study
ConclusionWe cautiously find that LDL-C and apoB was positively correlated with LAS. These findings suggest that the reducing LDL-C levels could be an effective prevention strategy for reducing the risk of stroke. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - July 17, 2023 Category: Neurology Source Type: research
At a glance: the largest Niemann-Pick type C1 cohort with 602 patients diagnosed over 15 years
European Journal of Human Genetics, Published online: 11 July 2023; doi:10.1038/s41431-023-01408-7At a glance: the largest Niemann-Pick type C1 cohort with 602 patients diagnosed over 15 years (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - July 11, 2023 Category: Genetics & Stem Cells Authors: Pilar Guatibonza Moreno Luba M. Pardo Catarina Pereira Sabine Schroeder Deepthi Vagiri Ligia S. Almeida Carlos Juaristi Heba Hosny Clarice C. Y. Loh Anika Leubauer Galina Torres Morales Sebastian Oppermann Marius-Ionu ț Iurașcu Steffen Fischer Tara-Mari Source Type: research
Investigation of Brain Iron in Niemann-Pick Type C: A 7T Quantitative Susceptibility Mapping Study [FUNCTIONAL]
CONCLUSIONS:
Our findings suggest iron deposition in the pulvinar nucleus in Niemann-Pick type C disease, which is associated with thalamic atrophy and disease severity. This preliminary evidence supports the link between iron and neurodegeneration in Niemann-Pick type C, in line with existing literature on other neurodegenerative disorders. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - July 10, 2023 Category: Radiology Authors: Ravanfar, P., Syeda, W. T., Rushmore, R. J., Moffat, B., Lyall, A. E., Merritt, A. H., Devenyi, G. A., Chakravarty, M. M., Desmond, P., Cropley, V. L., Makris, N., Shenton, M. E., Bush, A. I., Velakoulis, D., Pantelis, C., Walterfang, M. Tags: FUNCTIONAL Source Type: research
Neonatal onset of Niemann-Pick disease type C in a patient with cholesterol re-accumulation in the transplanted liver and inflammatory bowel disease
We report the case of a girl with NPC who had a re- accumulation of cholesterol in the transplanted liver and NPC-related IBD. (Source: Brain and Development)
Source: Brain and Development - July 8, 2023 Category: Neurology Authors: Kiri Koshu, Kazuhiro Muramatsu, Tomomi Maru, Yoshie Kurokawa, Yoshitaka Mizobe, Hirokazu Yamagishi, Daisuke Matsubara, Koji Yokoyama, Eriko Jimbo, Hideki Kumagai, Yukihiro Sanada, Yasunaru Sakuma, Noriyoshi Fukushima, Aya Narita, Takanori Yamagata, Hitosh Tags: Case Report Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Mol Biol Cell - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
