Integrating Mass Spectrometry-based Proteomics and Lipidomics Reveals Biomarkers and Altered Signaling Pathways During Progressive Neurodegeneration in Niemann-Pick Disease, type C1
Proteomics Interest Group
Advances in mass spectrometry technology have enabled large-scale differential analysis of proteins and lipids to investigate altered pathways in human disease. Our laboratory studies Niemann-Pick Disease, type C1 (NPC1) a lysosomal storage disorder with visceral involvement and progressive cerebellar neurodegeneration. Using a combination of differential proteomics, lipidomics and mass spectrometry imaging, we have identified new candidate biomarkers in a mouse model of NPC1. These alterations now provide a basis for evaluation in NPC1 patients and also can be used for therapeutic development. Se...
Source: Videocast - All Events - February 1, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCD Beyond the Lab, Understanding Communication Disorders
Designed for administrative and support staff as well as scientists, the Beyond the Lab, Understanding Communication Disorders speaker series gives the NIH community an opportunity to learn about the National Institute on Deafness and Other Communication Disorder’s (NIDCD) research and research advances.
Learn about the NIDCD’s Audiology Unit, its contribution to biomedical research and the NIH mission, and its involvement in research evaluating a new therapy for Niemann-Pick disease type C (NPC). NPC is a rare cholesterol storage disorder that primarily affects children and is often fatal by early adulthood. NPC dam...
Source: Videocast - All Events - April 20, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
