Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion
Neurobiol Dis. 2023 Apr 28:106141. doi: 10.1016/j.nbd.2023.106141. Online ahead of print.ABSTRACTNiemann Pick diseases types A (NPDA) and C (NPDC) are lysosomal storage disorders (LSDs) leading to cognitive impairment, neurodegeneration, and early death. NPDA and NPDC have different genetic origins, being caused by mutations in the acid sphingomyelinase (ASM) or the cholesterol transport protein NPC1, respectively. However, they share a common pathological hallmark in the accumulation of lipids in the endolysosomal compartment. Here, we tested the hypothesis that polyphenols reduce lipid overload in NPD cells by enhancing ...
Source: Neurobiology of Disease - April 30, 2023 Category: Neurology Authors: Beatriz Soto-Huelin Bohdan Babiy Oscar Pastor Mario D íaz-García Ana Toledano-Zaragoza Mar ía Dolores Frutos Juan Carlos Esp ín Francisco A Tom ás-Barberán Rebeca Busto Mar ía Dolores Ledesma Source Type: research
Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion
Neurobiol Dis. 2023 Apr 28:106141. doi: 10.1016/j.nbd.2023.106141. Online ahead of print.ABSTRACTNiemann Pick diseases types A (NPDA) and C (NPDC) are lysosomal storage disorders (LSDs) leading to cognitive impairment, neurodegeneration, and early death. NPDA and NPDC have different genetic origins, being caused by mutations in the acid sphingomyelinase (ASM) or the cholesterol transport protein NPC1, respectively. However, they share a common pathological hallmark in the accumulation of lipids in the endolysosomal compartment. Here, we tested the hypothesis that polyphenols reduce lipid overload in NPD cells by enhancing ...
Source: Neurobiology of Disease - April 30, 2023 Category: Neurology Authors: Beatriz Soto-Huelin Bohdan Babiy Oscar Pastor Mario D íaz-García Ana Toledano-Zaragoza Mar ía Dolores Frutos Juan Carlos Esp ín Francisco A Tom ás-Barberán Rebeca Busto Mar ía Dolores Ledesma Source Type: research
Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion
Neurobiol Dis. 2023 Apr 28:106141. doi: 10.1016/j.nbd.2023.106141. Online ahead of print.ABSTRACTNiemann Pick diseases types A (NPDA) and C (NPDC) are lysosomal storage disorders (LSDs) leading to cognitive impairment, neurodegeneration, and early death. NPDA and NPDC have different genetic origins, being caused by mutations in the acid sphingomyelinase (ASM) or the cholesterol transport protein NPC1, respectively. However, they share a common pathological hallmark in the accumulation of lipids in the endolysosomal compartment. Here, we tested the hypothesis that polyphenols reduce lipid overload in NPD cells by enhancing ...
Source: Neurobiology of Disease - April 30, 2023 Category: Neurology Authors: Beatriz Soto-Huelin Bohdan Babiy Oscar Pastor Mario D íaz-García Ana Toledano-Zaragoza Mar ía Dolores Frutos Juan Carlos Esp ín Francisco A Tom ás-Barberán Rebeca Busto Mar ía Dolores Ledesma Source Type: research
"MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression"
Biochim Biophys Acta Gene Regul Mech. 2023 Apr 20:194938. doi: 10.1016/j.bbagrm.2023.194938. Online ahead of print.ABSTRACTDysregulation of cholesterol homeostasis is associated with several pathologies including cardiovascular diseases and neurological disorders such as Alzheimer's disease (AD). MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of cholesterol metabolism. We previously established the role of miR-7 in regulating insulin resistance and amyloidosis, which represents a common pathological feature between type 2 diabetes and AD. We show here an additional metabolic function of miR-7 in cho...
Source: Biochimica et Biophysica Acta - April 22, 2023 Category: Biochemistry Authors: Mario Fern ández-de Frutos Virginia Pardo-Marqu és Marta Torrecilla-Parra Patricia Rada Ana P érez-García Yolanda Mart ín-Martín Gema de la Pe ña Ana G ómez Ana Toledano-Zaragoza Diego G ómez-Coronado Mar ía José Casarejos Jos é M Solís Noem Source Type: research
"MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression"
Biochim Biophys Acta Gene Regul Mech. 2023 Apr 20:194938. doi: 10.1016/j.bbagrm.2023.194938. Online ahead of print.ABSTRACTDysregulation of cholesterol homeostasis is associated with several pathologies including cardiovascular diseases and neurological disorders such as Alzheimer's disease (AD). MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of cholesterol metabolism. We previously established the role of miR-7 in regulating insulin resistance and amyloidosis, which represents a common pathological feature between type 2 diabetes and AD. We show here an additional metabolic function of miR-7 in cho...
Source: Biochimica et Biophysica Acta - April 20, 2023 Category: Biochemistry Authors: Mario Fern ández-de Frutos Virginia Pardo-Marqu és Marta Torrecilla-Parra Patricia Rada Ana P érez-García Yolanda Mart ín-Martín Gema de la Pe ña Ana G ómez Ana Toledano-Zaragoza Diego G ómez-Coronado Mar ía José Casarejos Jos é M Solís Noem Source Type: research
Novel polyketide from < em > Fusarium verticillioide < /em > G102 as NPC1L1 inhibitors
Nat Prod Res. 2023 Apr 19:1-7. doi: 10.1080/14786419.2023.2201885. Online ahead of print.ABSTRACTOne novel polyketide, fusaritide A (1), was isolated from a marine fish-derived halotolerant fungal strain Fusarium verticillioide G102. The structure was determined through extensive spectroscopic analysis and high-resolution electrospray ionization mass spectrometry. Fusaritide A (1) with unprecedented structure reduced cholesterol uptake by inhibiting Niemann-Pick C1-Like 1 (NPC1L1).PMID:37074061 | DOI:10.1080/14786419.2023.2201885 (Source: Natural Product Research)
Source: Natural Product Research - April 19, 2023 Category: Biochemistry Authors: Yuhan Zhang Wenjing Liu Gang Li Changzheng Wu Jing Yan Dan Feng Shuangzhi Yuan Renshuai Zhang Hongxiang Lou Xiaoping Peng Source Type: research
