Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
Adenosine A < sub > 2A < /sub > Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages
Curr Issues Mol Biol. 2023 Jun 7;45(6):4948-4969. doi: 10.3390/cimb45060315.ABSTRACTAdenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. T...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Adrienn Skop ál Gyula Ujlaki Attila Tibor Gerencs ér Csaba Bank ó Zsolt Bacs ó Francisco Ciruela L ászló Virág Gy örgy Haskó Endre K ókai Source Type: research
GSE152158 RNA-seq of Niemann-Pick Type C mouse microglia throughout disease course
Contributors : Liana N Bonanno ; Tony Wyss-CoraySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHere we perform RNAsequencing on isolated microglia from wild-type and NP-C mice throughout disease course. We sequence microglia from WT and NPC mice at 1, 3, 6, and 9 weeks old. We also treat mice with the CSF1R inhibitor PLX5622 and sequence remaining microglia from treated and control mice. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 9, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Late adult-onset Niemann Pick type C (NPC): An “atypical” typical presentation at the age of 62
We report a 67-year-old woman with a 5-year history of progressive walking and balance difficulties with near-fall episodes. Gradually she also developed fine motor and speech problems that progressively impacted her communication. Swallowing function was unremarkable, and there was no history of choking episodes in the past. She had an uneventful neonatal period, with normal psychomotor development and unremarkable family history. Past medical history was positive for status post-cholecystectomy, hypertriglyceridemia, gastric bypass surgery (obesity) and mild obstructive sleep apnea. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - June 9, 2023 Category: Neurology Authors: M. Sousa, B. Maamari, T. Bremova, J.M. Nuoffer, R. Wiest, D. Amstutz, P. Krack, D. Bartholdi, G. Tinkhauser Source Type: research
GSE221609 The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells snRNA-Seq
Contributors : Thaddeus J Kunkel ; Alice Townsend ; Kyle A Sullivan ; Jean Merlet ; Daniel A Jacobson ; Andrew P LiebermanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCholesterol is required for oligodendrocyte maturation and CNS myelination. Here, we demonstrate an essential role for the intracellular cholesterol transporter NPC1 in these processes. NPC1 functions in late endosomes and lysosomes to efflux unesterified cholesterol, and its deficiency causes Niemann-Pick disease Type C, an autosomal recessive lysosomal disorder characterized by progressive neurodegeneration and ea...
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE221336 The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells bulk RNA-seq of mouse OPCs
This study sought to determine the genes being directly impacted by the epigenetic dysfunction at H3K27. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
