Neoadjuvant Chemotherapy Therapy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effects of neoadjuvant chemotherapy vs chemoradiotherapy in the treatment of esophageal adenocarcinoma: A systematic review and meta-analysis
CONCLUSION: Although nCRT may have a higher pCR rate, it does not translate to greater long-term survival. Moreover, nCRT is associated with higher 30-d mortality, although the specific cause for postoperative complications could not be identified. In the case of nCT, toxic side effects are suspected, which can reduce the quality of life. Given the quality of available studies, further randomized trials are required.PMID:38617451 | PMC:PMC11008422 | DOI:10.3748/wjg.v30.i11.1621 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Armand Csontos Al íz Fazekas Lajos Szak ó Nelli Farkas Csenge Papp Szil árd Ferenczi Szabolcs Bellyei P éter Hegyi Andr ás Papp Source Type: research

Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research

Effects of neoadjuvant chemotherapy vs chemoradiotherapy in the treatment of esophageal adenocarcinoma: A systematic review and meta-analysis
CONCLUSION: Although nCRT may have a higher pCR rate, it does not translate to greater long-term survival. Moreover, nCRT is associated with higher 30-d mortality, although the specific cause for postoperative complications could not be identified. In the case of nCT, toxic side effects are suspected, which can reduce the quality of life. Given the quality of available studies, further randomized trials are required.PMID:38617451 | PMC:PMC11008422 | DOI:10.3748/wjg.v30.i11.1621 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Armand Csontos Al íz Fazekas Lajos Szak ó Nelli Farkas Csenge Papp Szil árd Ferenczi Szabolcs Bellyei P éter Hegyi Andr ás Papp Source Type: research

Utility of human epidermal growth factor 2 heterogeneity as a prognostic factor in triple-negative breast cancer
Med Mol Morphol. 2024 Apr 15. doi: 10.1007/s00795-024-00386-z. Online ahead of print.ABSTRACTIn some cases of human epidermal growth factor 2 (HER2)-negative breast cancer, including triple-negative breast cancer, HER2 expression is sporadically and strongly upregulated, a condition known as HER2 heterogeneity. We investigated the clinicopathological features of patients with HER2 heterogeneity in triple-negative breast cancers treated with neoadjuvant chemotherapy. Thirty-nine patients with triple-negative breast cancer who had undergone preoperative chemotherapy participated in this study. To assess for HER2 heterogeneit...
Source: Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Eriko Narusawa Sasagu Kurozumi Ayaka Katayama Yukio Koibuchi Akira Ogawa Daisuke Takata Shoko Tokuda Sayaka Obayashi Tetsunari Oyama Jun Horiguchi Ken Shirabe Takaaki Fujii Source Type: research

Biofunctional study on chemoresistance in esophageal squamous carcinoma cells induced by missense mutation of NOTCH1 p.E450K 
CONCLUSIONS: The NOTCH1 p.E450K point mutation causes chemotherapy resistance in KYSE140 and KYSE450 ESCC cells. Cell functional experiments showed that the NOTCH1 p.E450K point mutation enhanced the proliferation, migration and invasion abilities of KYSE140 and KYSE450 cells and increased the number of cells in S phase.PMID:38617785 | PMC:PMC11009606 | DOI:10.21037/jtd-23-1880 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Keting Li Wentao Hao Jiwei Wu Xianben Liu Wenqun Xing Yan Zheng Source Type: research

Comparisons of short-term outcomes between robot-assisted, video-assisted, and open esophagectomy for resectable esophageal cancer after neoadjuvant treatment: a retrospective study
CONCLUSIONS: Compared to VAMIE, no clear benefit exists for RAE in the treatment of resectable EC after neoadjuvant therapy. OE resulted in a longer hospital stay. Although the rate of successful right RLN node removal was higher with RAE, the clinical relevance for this is yet unclear.PMID:38617777 | PMC:PMC11009584 | DOI:10.21037/jtd-24-75 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 15, 2024 Category: Respiratory Medicine Authors: Ziheng Wu Jiacong Liu Lichen Zhang Muhu Tang Wenbo Shu Berend J van der Wilk Christopher J Anker Zhehao He Luming Wang Wang Lv Linhai Zhu Jian Hu Source Type: research

Perioperative Immunotherapy for Node-Negative Non-Small Cell Lung Cancer - Current Evidence and Future Directions
Ann Thorac Surg. 2024 Apr 13:S0003-4975(24)00280-7. doi: 10.1016/j.athoracsur.2024.03.035. Online ahead of print.ABSTRACTNeoadjuvant immunotherapy has gone from an idea to an indication in locally advanced lung cancer. Several phase III trials have demonstrated the superiority of neoadjuvant chemoimmunotherapy compared to chemotherapy in this setting. Although such progress has revolutionized the treatment of locally advanced disease, the unmet needs of stage I and stage II patients without lymph node disease have largely been under-represented in existing trials. Up-front surgery with few patients going on to complete adj...
Source: The Annals of Thoracic Surgery - April 15, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Muhammad H Shahzad Jonathan D Spicer Valerie W Rusch Peter J Kneuertz Source Type: research

Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research

Effects of neoadjuvant chemotherapy vs chemoradiotherapy in the treatment of esophageal adenocarcinoma: A systematic review and meta-analysis
CONCLUSION: Although nCRT may have a higher pCR rate, it does not translate to greater long-term survival. Moreover, nCRT is associated with higher 30-d mortality, although the specific cause for postoperative complications could not be identified. In the case of nCT, toxic side effects are suspected, which can reduce the quality of life. Given the quality of available studies, further randomized trials are required.PMID:38617451 | PMC:PMC11008422 | DOI:10.3748/wjg.v30.i11.1621 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Armand Csontos Al íz Fazekas Lajos Szak ó Nelli Farkas Csenge Papp Szil árd Ferenczi Szabolcs Bellyei P éter Hegyi Andr ás Papp Source Type: research

Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research