Neoadjuvant Chemotherapy Therapy Forums This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Breast RNI and IMN coverage Discussion.... Again. Breast is the worst x 4?
New breast is the worst case. Just saw a 39 yo with a BRCA mutation who had what was called a cT2N2 ER+ PR-/HER2- breast cancer. This was in the setting of a biopsied 4.6 cm primary and an MRI with 7 abnormal-appearing axillary nodes, none of which were biopsied. Got neoadjuvant chemo followed by lumpectomy and ax dissection. Final staging was ypT1aN0. Residual primary was 1.5 mm with treatment effect noted. 0/17 nodes with no treatment effect noted. For reference, an abnormal node... Read more (Source: Student Doctor Network)
Source: Student Doctor Network - April 3, 2024 Category: Universities & Medical Training Authors: Ray D. Ayshun Tags: Radiation Oncology Source Type: forums

Retroperitoneal sarcoma delineation
Hello! I have a question concerning the delineation of a retroperitoneal sarcoma. This patient has a dedifferentiated RPS, the biopsy was performed in the solid mass in the upper left abdomen. It's a high-grade liposarcoma, not metastatic. However, as you can see, there is a considerable mass, which likely represents well differentiated sarcoma, reaching very far into the pelvis. Neoadjuvant treatment is planned with chemo + RT, followed by surgery. Would any of you... Read more (Source: Student Doctor Network)
Source: Student Doctor Network - March 21, 2024 Category: Universities & Medical Training Authors: Palex80 Tags: Radiation Oncology Source Type: forums

Photons vs. Protons for Esophageal Cancer
Hey, I wanna hear your feedback on this one. I just found out that this trial is running protecttrial.eu protecttrial.eu A randomized Phase III trial on photons vs. protons for neoadjuvant chemorads in esophageal cancer. The trial will cost roughly 5 million dollars IMI Innovative Medicines Initiative | PROTECT-trial | Proton versus photon therapy for esophageal cancer - a trimodality strategy Radiotherapy plays a key role in the ...
Source: Student Doctor Network - August 23, 2023 Category: Universities & Medical Training Authors: Palex80 Tags: Radiation Oncology Source Type: forums

Asco 2023
Abstracts are out. A selection of interesting stuff: LBAs (results pending): https://meetings.asco.org/abstracts-presentations/218388 This is the long awaited late breaking abstract of PEACE-1, testing RT to the prostate for mHSPC. Perhaps confirmation of STAMPEDE Arm-H results, perhaps not. https://meetings.asco.org/abstracts-presentations/219804 Phase III trial on chemo-RT vs. chemo as neoadjuvant treatment of rectal cancer. I have a bad feeling about this... Read more (Source: Student Doctor Network)
Source: Student Doctor Network - May 26, 2023 Category: Universities & Medical Training Authors: Palex80 Tags: Radiation Oncology Source Type: forums

when do you use SCRT (25Gy/5fr) within a total neoadjuvant approach for Rectal Ca?
Dear Colleagues, I am interested to know when do you favor standard LCRT versus SCRT in the setting of a TNT approach for rectal cancer? What are the criterias you follow ? does the age matter (young versus elderly)? location (lower/upper rectum)? sphincter involvement? sequencing (induction chemo versus upfront RT)? Any other considerations? ty a lot for sharing your thoughts (Source: Student Doctor Network)
Source: Student Doctor Network - November 29, 2022 Category: Universities & Medical Training Authors: Kroll2013 Tags: Radiation Oncology Source Type: forums

Neoadjuvant FLOT/MAGIC vs. CROSS in Distal Esophageal
I'm at a major academic center and the other day it was suggested that we should start considering neoadjuvant chemo alone for distal esophageal cancers based on this abstract at ASCO. Every single reported metric in the table below was superior for CROSS and yet the conclusion was "the data strongly suggests non-inferiority and equipoise." When us doom and gloomers talk about the declining indications for radiation it's because of things like this. We're perpetually one successful chemo... Read more (Source: Student Doctor Network)
Source: Student Doctor Network - March 31, 2022 Category: Universities & Medical Training Authors: RSAOaky Tags: Radiation Oncology Source Type: forums

PREOPANC Discussion
Can a GI specialist decipher this for me? Big wig med onc at MDACC. At first it seemed to me he was speaking positively about neoadjuvant chemoRT, but then in his reply to a commenter it seems like maybe I misinterpreted? (Source: Student Doctor Network)
Source: Student Doctor Network - February 1, 2022 Category: Universities & Medical Training Authors: Krukenberg Tags: Radiation Oncology Source Type: forums

Re: Remote, proactive, telephone based management of toxicity in outpatients during adjuvant or neoadjuvant chemotherapy for early stage breast cancer: pragmatic, cluster randomised trial
(Source: BMJ Comments)
Source: BMJ Comments - December 20, 2021 Category: General Medicine Source Type: forums

CROSS regimen on the chopping block
Tried to see if this was limited to Siewert II/III but seems all locations allowed: NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study (Neo-AEGIS) - Full Text View - ClinicalTrials.gov So periop chemo may become an option now for esophagus… (Source: Student Doctor Network)
Source: Student Doctor Network - June 6, 2021 Category: Universities & Medical Training Authors: frijoles Tags: Radiation Oncology Source Type: forums

Nodal ITC after neoadjuvant chemotherapy
Dear colleagues, I would greatly appreciate your input on this situation. cT2N0 triple positive breast cancer. Mastectomy and axillary clearance after neoadjuvant chemotherapy shows pCR in the breast and sentinel node biopsy shows ITC. RT? Leave alone? Thanks (Source: Student Doctor Network)
Source: Student Doctor Network - October 5, 2020 Category: Universities & Medical Training Authors: Treat Tags: Radiation Oncology Source Type: forums

Locally-Advanced Duodenal Cancers
I know these are rare, but curious how other people are practicing. Just saw a guy who presented with a proximal tumor and multiple positive nodes. They gave him upfront FOLFOX and he actually progressed clinically (no radiographic response but worsening clinical symptoms though not even close to obstructed). I was honestly surprised how "controversial" this case was at our tumor board and I am curious what everyone would recommend? I (successfully) argued for neoadjuvant chemorads. Some of... Locally-Advanced Duodenal Cancers (Source: Student Doctor Network)
Source: Student Doctor Network - April 30, 2020 Category: Universities & Medical Training Authors: ramsesthenice Tags: Radiation Oncology Source Type: forums

Is PMRT needed for this patient?
59 yo female patient, that presented with multifocal right breast lesions in the upper-lower outer quadrants: T1 26.5*21 mm - T2 23*19mm cN0 on the initial MRI. staging Pet: N0 M0 she underwent neoadjuvant chemotherapy. MRI showed a good radiological response she had total mastectomy and LND: bifocal residual carcinoma, T1: ILC, 3.7 cm T2: IDC, grade 2 negative margins, lVSI neg, skin free, nipple free, 0/21 negative nodes with no signs of... Is PMRT needed for this patient? (Source: Student Doctor Network)
Source: Student Doctor Network - August 16, 2019 Category: Universities & Medical Training Authors: Kroll2013 Tags: Radiation Oncology Source Type: forums

Breast boost after complete response to neoadjCT
39 y/o with triple-negative breast cancer, 1.9 cm in size, had lumpectomy after neoadjuvant chemo which showed complete response. I'm treating whole breast to 42.6/16. Would anyone omit boost? Thanks. (Source: Student Doctor Network)
Source: Student Doctor Network - July 17, 2019 Category: Universities & Medical Training Authors: seper Tags: Radiation Oncology Source Type: forums

PMRT for this patient?
Dear colleagues, i need your opinion concerning this patient: 44 yo patient diagnosed of a bifocal mass of the right breast 5*2*3 cm , UOQ, cN0 , no suspiscious nodes on MRI biopsy showed a poorly differentiated IDC with extensive high grade DCIS, HR neg, Her2 positive she received neoadjuvant chemotherapy with complete response. pathology of the radical right mastectomy with sentinel node showed: no residual tumor, 0/1 LN, LVSI was not specified. do you give PMRT taking into... PMRT for this patient? (Source: Student Doctor Network)
Source: Student Doctor Network - May 30, 2019 Category: Universities & Medical Training Authors: Kroll2013 Tags: Radiation Oncology Source Type: forums

Re: Effect of adoption of neoadjuvant chemotherapy for advanced ovarian cancer on all cause mortality: quasi-experimental study
(Source: BMJ Comments)
Source: BMJ Comments - February 13, 2019 Category: General Medicine Source Type: forums