Biofunctional study on chemoresistance in esophageal squamous carcinoma cells induced by missense mutation of < em > NOTCH1 p.E450K < /em >

CONCLUSIONS: The NOTCH1 p.E450K point mutation causes chemotherapy resistance in KYSE140 and KYSE450 ESCC cells. Cell functional experiments showed that the NOTCH1 p.E450K point mutation enhanced the proliferation, migration and invasion abilities of KYSE140 and KYSE450 cells and increased the number of cells in S phase.PMID:38617785 | PMC:PMC11009606 | DOI:10.21037/jtd-23-1880
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Authors: Source Type: research