LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development
Sex Dev. 2021 Sep 10:1-15. doi: 10.1159/000518323. Online ahead of print.ABSTRACTLIM homeodomain (LIM-HD) family genes are transcription factors that play crucial roles in a variety of functions during embryonic development. The activities of the LIM-HD proteins are regulated by the co-regulators LIM only (LMO) and LIM domain-binding (LDB). In the mouse genome, there are 13 LIM-HD genes (Lhx1-Lhx9, Isl1-2, Lmx1a-1b), 4 Lmo genes (Lmo1-4), and 2 Ldb genes (Ldb1-2). Amongst these, Lhx1 is required for the development of the müllerian duct epithelium and the timing of the primordial germ cell migration. Lhx8 is necessary for...
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - September 14, 2021 Category: Genetics & Stem Cells Authors: Neha Singh Domdatt Singh Deepak Modi Source Type: research
LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development
Sex Dev. 2021 Sep 10:1-15. doi: 10.1159/000518323. Online ahead of print.ABSTRACTLIM homeodomain (LIM-HD) family genes are transcription factors that play crucial roles in a variety of functions during embryonic development. The activities of the LIM-HD proteins are regulated by the co-regulators LIM only (LMO) and LIM domain-binding (LDB). In the mouse genome, there are 13 LIM-HD genes (Lhx1-Lhx9, Isl1-2, Lmx1a-1b), 4 Lmo genes (Lmo1-4), and 2 Ldb genes (Ldb1-2). Amongst these, Lhx1 is required for the development of the müllerian duct epithelium and the timing of the primordial germ cell migration. Lhx8 is necessary for...
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - September 14, 2021 Category: Genetics & Stem Cells Authors: Neha Singh Domdatt Singh Deepak Modi Source Type: research
LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development
Sex Dev. 2021 Sep 10:1-15. doi: 10.1159/000518323. Online ahead of print.ABSTRACTLIM homeodomain (LIM-HD) family genes are transcription factors that play crucial roles in a variety of functions during embryonic development. The activities of the LIM-HD proteins are regulated by the co-regulators LIM only (LMO) and LIM domain-binding (LDB). In the mouse genome, there are 13 LIM-HD genes (Lhx1-Lhx9, Isl1-2, Lmx1a-1b), 4 Lmo genes (Lmo1-4), and 2 Ldb genes (Ldb1-2). Amongst these, Lhx1 is required for the development of the müllerian duct epithelium and the timing of the primordial germ cell migration. Lhx8 is necessary for...
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - September 14, 2021 Category: Genetics & Stem Cells Authors: Neha Singh Domdatt Singh Deepak Modi Source Type: research
LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development
Sex Dev. 2021 Sep 10:1-15. doi: 10.1159/000518323. Online ahead of print.ABSTRACTLIM homeodomain (LIM-HD) family genes are transcription factors that play crucial roles in a variety of functions during embryonic development. The activities of the LIM-HD proteins are regulated by the co-regulators LIM only (LMO) and LIM domain-binding (LDB). In the mouse genome, there are 13 LIM-HD genes (Lhx1-Lhx9, Isl1-2, Lmx1a-1b), 4 Lmo genes (Lmo1-4), and 2 Ldb genes (Ldb1-2). Amongst these, Lhx1 is required for the development of the müllerian duct epithelium and the timing of the primordial germ cell migration. Lhx8 is necessary for...
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - September 14, 2021 Category: Genetics & Stem Cells Authors: Neha Singh Domdatt Singh Deepak Modi Source Type: research
LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development
Sex Dev. 2021 Sep 10:1-15. doi: 10.1159/000518323. Online ahead of print.ABSTRACTLIM homeodomain (LIM-HD) family genes are transcription factors that play crucial roles in a variety of functions during embryonic development. The activities of the LIM-HD proteins are regulated by the co-regulators LIM only (LMO) and LIM domain-binding (LDB). In the mouse genome, there are 13 LIM-HD genes (Lhx1-Lhx9, Isl1-2, Lmx1a-1b), 4 Lmo genes (Lmo1-4), and 2 Ldb genes (Ldb1-2). Amongst these, Lhx1 is required for the development of the müllerian duct epithelium and the timing of the primordial germ cell migration. Lhx8 is necessary for...
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - September 14, 2021 Category: Genetics & Stem Cells Authors: Neha Singh Domdatt Singh Deepak Modi Source Type: research
LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development
LIM homeodomain (LIM-HD) family genes are transcription factors that play crucial roles in a variety of functions during embryonic development. The activities of the LIM-HD proteins are regulated by the co-regulators LIM only (LMO) and LIM domain-binding (LDB). In the mouse genome, there are 13 LIM-HD genes (Lhx1–Lhx9,Isl1–2,Lmx1a–1b), 4 Lmo genes (Lmo1–4), and 2 Ldb genes (Ldb1–2). Amongst these,Lhx1 is required for the development of the m üllerian duct epithelium and the timing of the primordial germ cell migration.Lhx8 is necessary for oocyte differentiation andLhx9 for somatic cell proliferation in the geni...
Source: Sexual Development - September 10, 2021 Category: Biology Source Type: research
Methods for neovagina creation in women with Mayer-Rokitansky-K üster-Hauser syndrome for subsequent uterus transplantation
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021 Aug 24. doi: 10.5507/bp.2021.049. Online ahead of print.ABSTRACTMayer-Rokitansky-Küster-Hauser syndrome is a rare female congenital anomaly that presents with an inability to have coital sexual intercourse and absolute uterine factor infertility. Both surgical and nonsurgical approaches have been described for the treatment of vaginal agenesis to allow satisfactory coitus. Transplantation of the uterus has the challenge of achieving pregnancy and delivery of her own genetic and biological children in a woman without a natural uterus. Women of reproductive age with ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - August 27, 2021 Category: Biomedical Science Authors: Roman Chmel Zlatko Pastor Marta Novackova Nikoleta Chubanovova Roman Chmel Source Type: research
A case of neovagina surgical creation using the uterine cervix remnant in a patient with Mayer-Rokitansky-K üster-Hauser syndrome
To study the efficacy of a novel approach to vaginoplasty in a patient with vaginal aplasia and a preserved cervix. (Source: Fertility and Sterility)
Source: Fertility and Sterility - July 27, 2021 Category: Reproduction Medicine Authors: Mykhailo Medvediev, Dmytro Spesyvtsev, Dar'ya Pokrovenko Tags: Video Source Type: research
The Impact of Psychosexual Education on Promoting Sexual Function, Genital Self-Image, and Sexual Distress among Women with Rokitansky Syndrome: A Randomized Controlled Clinical Trial
: To assess the effectiveness of psychosexual education on promoting sexual function& genital self-image and reducing sexual distress through e-learning among women with MRKH syndrome. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - July 13, 2021 Category: OBGYN Authors: Nafiseh Vosoughi, Raziyeh Maasoumi, Ali Asghar Haeri Mehrizi, Zinat Ghanbari Source Type: research
The Effect of Psychosexual Education on Promoting Sexual Function, Genital Self-Image, and Sexual Distress among Women with Rokitansky Syndrome: A Randomized Controlled Clinical Trial
To assess the effectiveness of psychosexual education on promoting sexual function and genital self-image and reducing sexual distress through e-learning among women with Mayer –Rokitansky–Küster–Hauser (MRKH) syndrome. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - July 13, 2021 Category: OBGYN Authors: Nafiseh Vosoughi, Raziyeh Maasoumi, Ali Asghar Haeri Mehrizi, Zinat Ghanbari Tags: Original Study Source Type: research
Comparison of two laparoscopic vaginoplasties using a single peritoneal flap in patients with Mayer-Rokitansky-K üster-Hauser syndrome
ConclusionsBoth the Hebei I and Hebei II techniques are feasible approaches for creating a neovagina which can bring satisfactory anatomical and sexual outcomes in patients with MRKH syndrome. However, the Hebei II technique may be a good alternative to the Hebei I technique because of its relatively shorter operative time, fewer neovaginal secretions and fewer granulomatous polyps. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - July 2, 2021 Category: OBGYN Source Type: research
Disorders of sex development and female reproductive capacity: A literature review
Syst Biol Reprod Med. 2021 Jul 1:1-14. doi: 10.1080/19396368.2021.1937376. Online ahead of print.ABSTRACTDisorders of sex development (DSD) are a wide-ranging group of complex conditions that influence chromosomal, gonadal, and phenotypic sex. The prevalence of DSD is very low, but affected patients deserve individualized management to improve psychological, sexual, and reproductive outcomes. This review aims to clarify the fertility potential of DSD patients who can be reared as females and their chance of becoming pregnant, especially using assisted reproductive techniques (ART). Due to the effects of DSD on internal and...
Source: Reproductive Biology - July 1, 2021 Category: Reproduction Medicine Authors: Hossein Hosseinirad Pouya Yadegari Fatemeh Mohanazadeh Falahieh Soheila Nouraei Shahrokh Paktinat Nousha Afsharzadeh Yousef Sadeghi Source Type: research
