MRKH Syndrome Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ischial Spinous Fascia Fixation for Dilated Neovaginal Prolapse in Mayer-Rokitansky-K üster-Hauser Syndrome—2 Case Reports
Mayer-Rokitansky-K üster-Hauser (MRKH) syndrome, as congenital anomaly of the female reproductive tract, is characterized by the congenital absence of uterus and vagina. Dilation maneuver was recommended as the nonsurgical treatment for these patients. However, only several cases were reported depicting the prolapse of the dilated neovagina of patients with MRKH syndrome. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - November 4, 2021 Category: OBGYN Authors: Yuan Wang, Chang Ren, Xinmiao Bao, Jia Kang, Yidi Ma, Lan Zhu Source Type: research

Uterus transplantation worldwide: clinical activities and outcomes
Purpose of review Women with absolute uterine factor infertility, because of uterine absence, or the presence of a nonfunctional uterus, were regarded as being untreatable until 2014 when the first birth following uterus transplantation (UTx) took place in Sweden. This proof-of-concept occurred in a woman with Mayer–Rokitansky–Küster–Hauser syndrome (MRKHs) with congenital uterine absence, who received a uterus from a 61-year-old live donor (LD). Since then, several births after UTx have occurred in Sweden and subsequently in other countries, including both LD and deceased donor (DD) transplants. A great majorit...
Source: Current Opinion in Organ Transplantation - October 31, 2021 Category: Surgery Tags: VASCULARIZED COMPOSITE ALLOTRANSPLANTATION: Edited by Stefan G. Tullius Source Type: research

Intestinal obstruction secondary to malformation in a child with Mayer-Rokitansky-K üster-Hauser Syndrome
: Mayer-Rokitansky-K üster-Hauser syndrome (MRKH) is a congenital disorder characterized by underdevelopment of the uterus and vagina. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - October 19, 2021 Category: OBGYN Authors: Lii Jye Tan, Geok Chin Tan, Huzlinda Hussin, Mohammad Shafie Othman, Shau-Kong Lai Source Type: research

Laparoscopic Peritoneal Pull through Vaginoplasty with Ovarian Hitching to Facilitate Transvaginal Oocyte Retrieval for Mrkh Syndrome
Video demonstration of laparoscopic peritoneal pull through vaginoplasty using the midline bands and mobilization of ovaries in the pelvis to facilitate transvaginal oocyte retrieval in a case of MRKH. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 16, 2021 Category: OBGYN Authors: A.N. Tandon, S.N. Tandon, A.N Tandon Tags: 6399 Source Type: research

Creation of Neovagina Using Complete Laparoscopic Dissection
Exclusive laparoscopic dissection for creation of neovagina in MRKH (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 16, 2021 Category: OBGYN Authors: D Kansal Tags: Open Communications 13: Urogynecology Source Type: research

Uterus transplantation worldwide: clinical activities and outcomes
Curr Opin Organ Transplant. 2021 Oct 11. doi: 10.1097/MOT.0000000000000936. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Women with absolute uterine factor infertility, because of uterine absence, or the presence of a nonfunctional uterus, were regarded as being untreatable until 2014 when the first birth following uterus transplantation (UTx) took place in Sweden. This proof-of-concept occurred in a woman with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHs) with congenital uterine absence, who received a uterus from a 61-year-old live donor (LD). Since then, several births after UTx have occurred in Sweden and subseq...
Source: Current Opinion in Organ Transplantation - October 12, 2021 Category: Transplant Surgery Authors: Mats Br ännström Michael A Belfort Jean Marc Ayoubi Source Type: research

Renal agenesis, associated genital malformations, and responsible genes
The study of the possible genetic causes of complex genital malformations is a subject of great interest both to know its etiology and diagnosis and for the best genetic and reproductive advice in these patients. Recently, Chen et al. (1) published the article titled “Perturbations of Genes Essential for Müllerian Duct and Wolffian Duct Development in Mayer-Rokitansky-Kuster-Hauser Syndrome,” and in this issue of Fertility and Sterility, Li et al. (2) reported that “whole-exome sequencing revealed that renal agenesi s-related genes were mutated and may be associated with the Herlyn-Werner-Wunderlich syndrome.” ...
Source: Fertility and Sterility - September 18, 2021 Category: Reproduction Medicine Authors: Pedro Aci én, Maribel Acién Tags: Reflections Source Type: research

LIM Homeodomain (LIM-HD) Genes and Their Co-Regulators in Developing Reproductive System and Disorders of Sex Development
Sex Dev. 2021 Sep 10:1-15. doi: 10.1159/000518323. Online ahead of print.ABSTRACTLIM homeodomain (LIM-HD) family genes are transcription factors that play crucial roles in a variety of functions during embryonic development. The activities of the LIM-HD proteins are regulated by the co-regulators LIM only (LMO) and LIM domain-binding (LDB). In the mouse genome, there are 13 LIM-HD genes (Lhx1-Lhx9, Isl1-2, Lmx1a-1b), 4 Lmo genes (Lmo1-4), and 2 Ldb genes (Ldb1-2). Amongst these, Lhx1 is required for the development of the müllerian duct epithelium and the timing of the primordial germ cell migration. Lhx8 is necessary for...
Source: Sexual Development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - September 14, 2021 Category: Genetics & Stem Cells Authors: Neha Singh Domdatt Singh Deepak Modi Source Type: research